amyotrophic lateral sclerosis
rare neurodegenerative disease with amyotrophy and progressive paralysis
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Summary
amyotrophic lateral sclerosis is a designated intractable/rare disease[1]. It ranks in the top 0.99% of designated intractable rare disease entities by monthly Wikipedia readership (121,742 views/month, #2 of 201).[2]
Key Facts
- Instance of: rare disease[3], class of disease[4], symptom or sign[5]
- Named after: Lou Gehrig[6], Jean-Martin Charcot[7]
- Subclass of: motor neuron disease[8], TDP-43 Proteinopathies[9], neurodegeneration[10], monogenic disease[11]
- Commons category: Amyotrophic lateral sclerosis[12]
- ICPC 2 ID: N99[13]
- Afflicts: motor neuron[14]
- Topic's main category: Category:Amyotrophic lateral sclerosis[15]
- Medical examination: Awaji Criteria[16]
- Prevalence: 0.00005[17]
- External data available at URL: http://www.nanbyou.or.jp/entry/52[18]
- Described by source: The Unified Medical Dictionary (Librairie du Liban, 2009)[19]
- Topic has template: Template:Amyotrophic lateral sclerosis[20]
- Nickname: Lou Gehrig's disease[21]
- ICD-9-CM: 335.20[22]
- NCI Thesaurus ID: C34373[23]
- Short name: ELA[24], ALS[25]
- Health specialty: neurology[26]
- Drug or therapy used for treatment: riluzole[27], edaravone[28]
- Genetic association: ITGA9[29], CTNND2[30], TSPAN9[31], TFAP2A[32], ATP2B2[33], EPB41[34], LRRC8C[35], NFASC[36], SLC25A12[37], ERBB4[38], TRPM8[39], KCNMB2[40], MASP1[41], ANXA3[42]
Why It Matters
amyotrophic lateral sclerosis has Wikipedia articles in 30 language editions, a strong signal of global cultural recognition.[43] It is known by 151 alternative names across languages and contexts.[44]