gamma-secretase complex
protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin
Facts
4 properties- Instance of
- cellular component, group or class of transmembrane transport proteins, family of protein complexes[2][3]
- Subclass of
- plasma membrane protein complex, group translocator, aspartate protease, catalytic complex[4][5][6][7]
- Has part(s) of the class
- Peptidase A22A, presenilin 1, Nicastrin, Gamma-secretase subunit Aph-1, Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit[9][10][11][12]
- Molecular function
- aspartic endopeptidase activity, intramembrane cleaving[8]
🏷️ Also known as
en gamma-secretase complex
en γ-secretase
en γ secretase
en TCDB:4.G.1
en presenilin complex
en GO:0070765
en gamma secretase
en gamma-secretase
ar غاما سيكريتاز
cs gama-sekretáza
de Nicastrin
de Gamma-Sekretase
de APH-1
de PEN-2
ja γ-セクレターゼ
ja Γ-セクレターゼ
zh Γ分泌酶
🔖 Identifiers · 6
- OpenAlex ID
- C2778171954
- Exact match
- purl.obolibrary.org, tcdb.org
- Freebase ID
- /m/026b7cn
- Gene Ontology ID
- GO:0070765
- Microsoft Academic ID (discontinued)
- 2778171954
- Transporter Classification Database ID
- 4.G.1
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Summary
gamma-secretase complex is a cellular component[1].