amoxapine

chemical compound

Class type of: chemical compound Q58356

Facts

15 properties

Instance of: type of chemical entity
Subclass of: chemical compound
Has use: medication^[8]
Canonical SMILES: C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl^[6]
Chemical formula: C₁₇H₁₆ClN₃O^[7]
Defined daily dose: +0.15^[23]
Different from: emoxypine^[9]
Legal status (medicine): boxed warning^[22]
LiverTox likelihood score: LiverTox toxicity likelihood category E^[24]
Mass: +313.098^[10]
Medical condition treated: neurotic disorder, psychosis, major depressive disorder^[11]^[12]^[13]
Physically interacts with: 5-hydroxytryptamine receptor 6, Solute carrier family 6 member 2, solute carrier family 6 member 4^[3]^[4]^[5]
Pregnancy category: US pregnancy category C^[21]
Subject has role: selective serotonin reuptake inhibitor, dopamine antagonist, adrenergic uptake inhibitors, neurotransmitter uptake inhibitor, second-generation antidepressive agents, developmental toxicant^[15]^[16]^[17]^[18]^[19]^[20]
World Health Organisation international non-proprietary name: amoxapine^[14]

🏷️ Also known as

en Desmethylloxapin en amoxipine en Asendin® en 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine en 2-Chloro-11-(1-piperazinyl)dibenz(b,F)(1,4)oxazepine en Amoxapin en Amoxapina en amoxapine en Amoxapine en Amoxapinum en Amoxepine ar أَمُوكسَابِين ar أموكسابين fa آموکساپین fr 14028-44-5 fr C17H16ClN3O fr Defanyl he אמוקספין id Amoksapin ja C17H16ClN3O

🔖 Identifiers · 41

ATC code: N06AA17
CA PROP 65 ID: amoxapine
CAS Registry Number: 14028-44-5
ChEBI ID: 2675
ChEMBL ID: CHEMBL1113
ChemSpider ID: 2085
DSSTOX compound identifier: DTXCID102598
DSSTox substance ID: DTXSID7022598
DeCS ID: 672
DrugBank ID: DB00543
DrugCentral ID: 191
EC number: 237-867-1

Show all 41 identifiers +29

ECHA Substance Infocard ID: 100.034.411
Freebase ID: /m/03h4gm
Guide to Pharmacology Ligand ID: 201
Human Metabolome Database ID: HMDB0014683
InChI: InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2
InChIKey: QWGDMFLQWFTERH-UHFFFAOYSA-N
KEGG ID: D00228
LiverTox ID: Amoxapine
MassBank accession ID: MSBNK-Waters-WA002129, MSBNK-Waters-WA002130, MSBNK-Waters-WA002131, MSBNK-Waters-WA002132, MSBNK-Waters-WA002133
MeSH concept ID: M0001008
MeSH descriptor ID: D000657
MeSH term ID: T001967
MeSH tree code: D03.633.300.347.500.040
MedlinePlus drug identifier: a682202
Microsoft Academic ID (discontinued): 2781073338
NDF-RT ID: N0000146270
NSC number: 759559
Probes And Drugs ID: PD000076
PubChem CID: 2170
RTECS number: HQ4025500
Reaxys registry number: 832057
RxNorm CUI: 722
SPLASH: splash10-052b-4490000000-6bbd0d2c0c8fe332c636
SureChEMBL ID: 33950
UMLS CUI: C0002644
UNII: R63VQ857OT
UNSPSC code: 51141629
UniChem compound ID: 145618
WikiProjectMed ID: Amoxapine

Report an error or request removal Lineage (PROV-JSON)

🔗 Connections

Subject has role 3

selective serotonin reuptake inhibitor, adrenergic uptake inhibitors, dopamine antagonist

Medical condition treated 2

major depressive disorder, psychosis

← Drug or therapy used for treatment 2

major depressive disorder, psychosis

Different from 1

emoxypine

Has use 1

medication

Legal status (medicine) 1

boxed warning

Physically interacts with 1

solute carrier family 6 member 4

Subclass of 1

chemical compound

← Different from 1

emoxypine

← Physically interacts with 1

solute carrier family 6 member 4

← Research intervention 1

HEK293

← SNARC ID 1

Georges Darien

Press Enter · cited answer in seconds

Summary

amoxapine is a type of chemical entity^[1]. amoxapine is a type of chemical compound^[2].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[3] ↑ amoxapine — physically interacts with (P129): 5-hydroxytryptamine receptor 6. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ amoxapine — physically interacts with (P129): Solute carrier family 6 member 2. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[5] ↑ amoxapine — physically interacts with (P129): solute carrier family 6 member 4. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[6] ↑ amoxapine — canonical SMILES (P233): C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl. PubChem. Retrieved 2016-11-17. wikidata.org.
[7] ↑ amoxapine — chemical formula (P274): C₁₇H₁₆ClN₃O. PubChem. Retrieved 2016-11-17. wikidata.org.
[2] ↑ amoxapine — subclass of (P279): chemical compound. wikidata.org.
[8] ↑ amoxapine — has use (P366): medication. wikidata.org.
[9] ↑ amoxapine — different from (P1889): emoxypine. wikidata.org.
[10] ↑ amoxapine — mass (P2067): 313.098 dalton. PubChem. Retrieved 2016-11-17. wikidata.org.
[11] ↑ amoxapine — medical condition treated (P2175): neurotic disorder. NDF-RT. Retrieved 2016-12-13. wikidata.org.
[12] ↑ amoxapine — medical condition treated (P2175): psychosis. Inxight: Drugs Database. Retrieved 2018-11-02. drugs.ncats.io. Provenance: wikidata.org.
[13] ↑ amoxapine — medical condition treated (P2175): major depressive disorder. Inxight: Drugs Database. Retrieved 2018-11-02. drugs.ncats.io. Provenance: wikidata.org.
[14] ↑ amoxapine — World Health Organisation international non-proprietary name (P2275): amoxapine. ChEBI. Retrieved 2016-10-03. wikidata.org.
[15] ↑ amoxapine — subject has role (P2868): selective serotonin reuptake inhibitor. NDF-RT. Retrieved 2018-03-05. wikidata.org.
[16] ↑ amoxapine — subject has role (P2868): dopamine antagonist. NDF-RT. Retrieved 2018-03-05. wikidata.org.
[17] ↑ amoxapine — subject has role (P2868): adrenergic uptake inhibitors. NDF-RT. Retrieved 2018-03-05. wikidata.org.
[18] ↑ amoxapine — subject has role (P2868): neurotransmitter uptake inhibitor. Medical Subject Headings. Retrieved 2018-03-15. wikidata.org.
[19] ↑ amoxapine — subject has role (P2868): second-generation antidepressive agents. Medical Subject Headings. Retrieved 2018-03-15. wikidata.org.
[20] ↑ amoxapine — subject has role (P2868): developmental toxicant. California Proposition 65 list of chemicals. Retrieved 2020-02-19. oehha.ca.gov. Provenance: wikidata.org.
[21] ↑ amoxapine — pregnancy category (P3489): US pregnancy category C. wikidata.org.
[22] ↑ amoxapine — legal status (medicine) (P3493): boxed warning. nctr-crs.fda.gov. nctr-crs.fda.gov. Provenance: wikidata.org.
[23] ↑ amoxapine — defined daily dose (P4250): 0.15 g. whocc.no. whocc.no. Provenance: wikidata.org.
[24] ↑ amoxapine — LiverTox likelihood score (P8026): LiverTox toxicity likelihood category E. LiverTox. Retrieved 2021-04-08. ncbi.nlm.nih.gov. Provenance: wikidata.org.

Class ancestry

[1] ↑ amoxapine is an instance of type of chemical entity (Q113145171) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). amoxapine. Retrieved November 12, 2026, from https://4ort.xyz/entity/amoxapine

MLA “amoxapine.” 4ort.xyz Knowledge Graph, 4ort.xyz, 12 Nov. 2026, https://4ort.xyz/entity/amoxapine.

BibTeX

@misc{4ortxyz_amoxapine_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{amoxapine}}, year = {2026}, url = {https://4ort.xyz/entity/amoxapine}, note = {Accessed: 2026-11-12}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): amoxapine — https://4ort.xyz/entity/amoxapine (retrieved 2026-11-12)

Canonical URL: https://4ort.xyz/entity/amoxapine · Last refreshed: November 12, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

21w ago · Nabbegat · 2026-06-19 view diff on Wikidata ↗

Defined daily dose → 0.15 gram

Legal status (medicine) → boxed warning

Instance of → type of chemical entity

LiverTox likelihood score → LiverTox toxicity likelihood category E

+ 8 other properties edited (see Wikidata diff for full list)

"Changed [tr] labels, descriptions or aliases: QuickStatements 3.0 batch #37300"

Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.