tacrolimus
immunosuppressive Rx drug
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Summary
tacrolimus is a type of chemical entity[1]. tacrolimus ranks in the top 2% of type of chemical entity entities by monthly Wikipedia readership (5,482 views/month).[2]
Key Facts
- Physically interacts with: FKBP prolyl isomerase 1A[3]
- Manufacturer: Pfizer[4]
- Canonical SMILES: CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC[5]
- Chemical formula: C₄₄H₆₉NO₁₂[6]
- Subclass of: alkaloid[7], macrolides[8]
- Part of: FK506 binding[9]
- Has use: medication[10], chemical probe[11]
- Commons category: Tacrolimus[12]
- Route of administration: oral administration[13], intravenous infusion and defusionههبهلخل[14]
- Molecular function: FK506 binding[15]
- Found in taxon: Streptomyces hygroscopicus[16], Streptomyces tacrolimicus[17], Streptomyces clavuligerus[18], Penicillium[19]
- Significant drug interaction: valganciclovir[20], ganciclovir[21], cyclosporine[22], nabumetone[23], naproxen[24], celecoxib[25], Diclofenac[26], piroxicam[27], meloxicam[28], (RS)-fenoprofen[29], (±)-flurbiprofen[30], ibuprofen[31], indomethacin[32], (RS)-ketoprofen[33]
Why It Matters
tacrolimus has Wikipedia articles in 22 language editions, a strong signal of global cultural recognition.[34] tacrolimus is known by 31 alternative names across languages and contexts.[35]