PPARG coactivator 1 alpha

mammalian protein found in Rattus norvegicus

Class type of: protein Q28559561

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Summary

PPARG coactivator 1 alpha is a protein^[1].

Key Facts

Subclass of: protein^[2]
Part of: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha^[3], RNA-binding domain superfamily^[4], Nucleotide-binding alpha-beta plait domain superfamily^[5], PGC-1alpha, RNA recognition motif, protein family^[6], RNA recognition motif domain, protein family^[7]
Has part(s): RNA recognition motif domain^[8], PGC-1alpha, RNA recognition motif^[9]
Molecular function: nucleic acid binding^[10], DNA binding^[11], chromatin binding^[12], transcription coregulator activity^[13], transcription coactivator activity^[14], RNA binding^[15], signaling receptor binding^[16]

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Quick Facts

Instance of protein

Subclass of protein

Part of Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, RNA-binding domain superfamily, Nucleotide-binding alpha-beta plait domain superfamily, PGC-1alpha, RNA recognition motif, protein family, RNA recognition motif domain, protein family

Properties

Biological process response to reactive oxygen species, autophagy of mitochondrion, response to hypoxia, negative regulation of protein phosphorylation, response to dietary excess, response to ischemia, galactose metabolic process, gluconeogenesis, regulation of transcription, DNA-templated, mitochondrion organization, ageing, androgen metabolic process, response to cold, response to fructose, positive regulation of gene expression, positive regulation of mitochondrion organization, response to organic cyclic compound, skeletal muscle atrophy, response to activity, response to muscle activity, response to electrical stimulus involved in regulation of muscle adaptation, negative regulation of smooth muscle cell migration, fatty acid oxidation, cerebellum development, respiratory electron transport chain, forebrain development, positive regulation of cellular metabolic process, response to nutrient levels, circadian regulation of gene expression, cellular response to oxidative stress, cellular response to potassium ion, response to starvation, regulation of circadian rhythm, response to leucine, negative regulation of neuron apoptotic process, negative regulation of glycolytic process, positive regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, positive regulation of fatty acid oxidation, rhythmic process, positive regulation of smooth muscle cell proliferation, negative regulation of smooth muscle cell proliferation, brown fat cell differentiation, positive regulation of DNA-binding transcription factor activity, flavone metabolic process, response to electrical stimulus, adipose tissue development, cellular response to lipopolysaccharide, cellular response to nitrite, cellular response to caffeine, cellular response to fructose stimulus, cellular response to glucose stimulus, cellular response to interleukin-6, cellular response to tumor necrosis factor, cellular response to follicle-stimulating hormone stimulus, cellular response to estradiol stimulus, cellular response to fatty acid, cellular response to hypoxia, cellular response to transforming growth factor beta stimulus, response to epinephrine, response to norepinephrine, negative regulation of mitochondrial fission, energy homeostasis, response to thyroid hormone, cellular response to thyroid hormone stimulus, positive regulation of cold-induced thermogenesis, negative regulation of neuron death, response to metformin, positive regulation of cellular respiration, positive regulation of mitochondrial DNA metabolic process, positive regulation of muscle tissue development, positive regulation of glomerular visceral epithelial cell apoptotic process, cellular response to ionomycin, cellular response to resveratrol, response to methionine, adaptive thermogenesis, positive regulation of progesterone biosynthetic process, negative regulation of signaling receptor activity, regulation of NMDA receptor activity, positive regulation of ATP biosynthetic process

Cell component nucleus, nucleoplasm, cytoplasm, cytosol, PML body, cytosolic ribosome, soma, intracellular membrane-bounded organelle, apical dendrite

Encoded by Ppargc1a

Found in taxon brown rat

Has part(s) RNA recognition motif domain, PGC-1alpha, RNA recognition motif

Imported from wholeness_audit_2026-05-02

Molecular function nucleic acid binding, DNA binding, chromatin binding, transcription coregulator activity, transcription coactivator activity, RNA binding, signaling receptor binding, protein binding, transcription factor binding, nuclear receptor binding, estrogen receptor binding, nuclear receptor coactivator activity, chromatin DNA binding, ubiquitin protein ligase binding, peroxisome proliferator activated receptor binding, alpha-tubulin binding, sequence-specific DNA binding, promoter-specific chromatin binding

Identifiers (3)

Ensembl protein id ENSRNOP00000006071

Refseq protein id NP_112637, XP_038948416, XP_038948417, XP_038948418, XP_038948419, XP_038948420, XP_038948421, XP_038948422

Uniprot protein id Q9QYK2

🏷️ Also known as

en peroxisome proliferative activated receptor gamma coactivator 1 en peroxisome proliferative activated receptor, gamma, coactivator 1 alpha en peroxisome proliferator-activated receptor gamma coactivator 1-alpha en PGC-1-alpha en PGC-1alpha en PPAR-gamma coactivator 1-alpha en PPAR gamma coactivator 1alpha variant form-1 en Ppargc1a en PPARGC-1-alpha en Ppargc1a-vf1 en PPARG coactivator 1 alpha

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ PPARG coactivator 1 alpha — subclass of (P279): protein. UniProt. Retrieved 2017-01-19. wikidata.org.
[3] ↑ PPARG coactivator 1 alpha — part of (P361): Peroxisome proliferator-activated receptor gamma coactivator 1-alpha. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[4] ↑ PPARG coactivator 1 alpha — part of (P361): RNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ PPARG coactivator 1 alpha — part of (P361): Nucleotide-binding alpha-beta plait domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ PPARG coactivator 1 alpha — part of (P361): PGC-1alpha, RNA recognition motif, protein family. wikidata.org.
[7] ↑ PPARG coactivator 1 alpha — part of (P361): RNA recognition motif domain, protein family. wikidata.org.
[8] ↑ PPARG coactivator 1 alpha — has part(s) (P527): RNA recognition motif domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ PPARG coactivator 1 alpha — has part(s) (P527): PGC-1alpha, RNA recognition motif. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ PPARG coactivator 1 alpha — molecular function (P680): nucleic acid binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ PPARG coactivator 1 alpha — molecular function (P680): DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ PPARG coactivator 1 alpha — molecular function (P680): chromatin binding. Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ PPARG coactivator 1 alpha — molecular function (P680): transcription coregulator activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ PPARG coactivator 1 alpha — molecular function (P680): transcription coactivator activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ PPARG coactivator 1 alpha — molecular function (P680): RNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ PPARG coactivator 1 alpha — molecular function (P680): signaling receptor binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ PPARG coactivator 1 alpha is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

“PPARG coactivator 1 alpha.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/pparg-coactivator-1-alpha-q28559561.

BibTeX

@misc{4ortxyz_pparg-coactivator-1-alpha-q28559561_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{PPARG coactivator 1 alpha}}, year = {2026}, url = {https://4ort.xyz/entity/pparg-coactivator-1-alpha-q28559561}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): PPARG coactivator 1 alpha — https://4ort.xyz/entity/pparg-coactivator-1-alpha-q28559561 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/pparg-coactivator-1-alpha-q28559561 · Last refreshed: May 3, 2026