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Perforin 1

mammalian protein found in Homo sapiens
Protein protein Q21103279

Facts

9 properties
Instance of
protein
Part of
C2 domain superfamily, Membrane attack complex component/perforin/complement C9, C2 domain, protein family, Perforin-1, C2 domain, protein family, Membrane attack complex component/perforin (MACPF) domain, protein family, Membrane attack complex component/perforin domain, conserved site, protein family[2][3][4][5][6][7]
Biological process
cellular defense response, immunological synapse formation, cytolysis, apoptotic process, transmembrane transport, positive regulation of killing of cells of other organism, defense response to tumor cell, immune response to tumor cell, protein homooligomerization, defense response to virus, T cell mediated cytotoxicity
Cell component
integral component of membrane, extracellular region, endosome, plasma membrane, endosome lumen, membrane, cytosol, cytoplasmic vesicle, cytolytic granule, membrane[17][18][19]
Encoded by
PRF1
Found in taxon
Homo sapiens
Has part(s)
C2 domain, Membrane attack complex component/perforin (MACPF) domain, Membrane attack complex component/perforin domain, conserved site, Perforin-1, C2 domain[8][9][10][11]
Has parts
C2 domain, Membrane attack complex component/perforin (MACPF) domain, Membrane attack complex component/perforin domain, conserved site, Perforin-1, C2 domain
Molecular function
protein binding, metal ion binding, calcium ion binding, wide pore channel activity, identical protein binding[12][13][14][15][16]
🏷️ Also known as
en PRF1 en cytolysin en lymphocyte pore forming protein en lymphocyte pore-forming protein en perforin en perforin-1 en Perforin 1 en perforin 1 (pore forming protein) en PFP ar بيرفورين es Perforina fi Perforiini fr Perforine ja パーフォリン ko 퍼포린 ru Перфорины zh 穿孔素
🔖 Identifiers · 11
OpenAlex ID
C2776062744
Ensembl protein ID
ENSP00000362305, ENSP00000398568, ENSP00000492048
Freebase ID
/m/036lvr
Lex ID
perforin
MeSH descriptor ID
D054353
MeSH tree code
D12.776.543.695.875
Microsoft Academic ID (discontinued)
2776062744
RefSeq protein ID
NP_001076585, NP_005032
Transporter Classification Database ID
1.C.39.2.8
UMLS CUI
C0070410
UniProt protein ID
P14222

Report an error or request removal Lineage (PROV-JSON)

🔗 Connections
Cell component 3
plasma membrane, cytosol, endosome
Biological process 2
apoptotic process, cytolysis
Found in taxon 1
Homo sapiens
Instance of 1
protein
Molecular function 1
protein binding
← Different from 1
porphyrins
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Summary

Perforin 1 is a protein[1].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [3] ↑ . Retrieved . wikidata.org.
  3. [4] ↑ . wikidata.org.
  4. [5] ↑ . wikidata.org.
  5. [6] ↑ . wikidata.org.
  6. [7] ↑ . wikidata.org.
  7. [8] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  8. [9] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  9. [10] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  10. [11] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  11. [12] ↑ . A proteome-scale map of the human interactome network. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] ↑ . The structural basis for membrane binding and pore formation by lymphocyte perforin. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Perforin 1. Retrieved November 7, 2026, from https://4ort.xyz/entity/perforin-1
MLA “Perforin 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 7 Nov. 2026, https://4ort.xyz/entity/perforin-1.
BibTeX @misc{4ortxyz_perforin-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Perforin 1}}, year = {2026}, url = {https://4ort.xyz/entity/perforin-1}, note = {Accessed: 2026-11-07}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Perforin 1 — https://4ort.xyz/entity/perforin-1 (retrieved 2026-11-07)

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