Paraoxonase 3

mammalian protein found in Homo sapiens
Protein protein Q21120463
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Summary

Paraoxonase 3 is a protein[1].

Key Facts

  • Part of: Six-bladed beta-propeller, TolB-like[2], Paraoxonase2[3]
  • EC enzyme number: 3.1.1.2[4], 3.1.1.81[5], 3.1.8.1[6]
  • Molecular function: arylesterase activity[7], dihydrocoumarin hydrolase activity[8], 3,4-dihydrocoumarin hydrolase activity[9], aryldialkylphosphatase activity[10], hydrolase activity[11], protein homodimerization activity[12], metal ion binding[13], acyl-L-homoserine-lactone lactonohydrolase activity[14]
  • Cell component: extracellular exosome[15], intracellular membrane-bounded organelle[16], extracellular region[17], extracellular space[18]
  • Biological process: carboxylic acid catabolic process[19], negative regulation of superoxide anion generation[20], phenylacetate catabolic process[21], coumarin catabolic process[22], aromatic compound catabolic process[23], response to toxic substance[24], response to external stimulus[25], dephosphorylation[26], lipoxygenase pathway[27]
  • Encoded by: PON3[28]
  • Found in taxon: Homo sapiens[29]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [4] ↑ . UniProt. Retrieved . wikidata.org.
  4. [5] ↑ . UniProt. Retrieved . wikidata.org.
  5. [6] ↑ . UniProt. Retrieved . wikidata.org.
  6. [7] ↑ . The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [8] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [9] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [10] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [11] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [12] ↑ . Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] ↑ . Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] ↑ . Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [23] ↑ . Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [24] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [25] ↑ . The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [27] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [28] ↑ . UniProt. Retrieved . wikidata.org.
  28. [29] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Paraoxonase 3. Retrieved October 30, 2026, from https://4ort.xyz/entity/paraoxonase-3-q21120463
MLA “Paraoxonase 3.” 4ort.xyz Knowledge Graph, 4ort.xyz, 30 Oct. 2026, https://4ort.xyz/entity/paraoxonase-3-q21120463.
BibTeX @misc{4ortxyz_paraoxonase-3-q21120463_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Paraoxonase 3}}, year = {2026}, url = {https://4ort.xyz/entity/paraoxonase-3-q21120463}, note = {Accessed: 2026-10-30}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Paraoxonase 3 — https://4ort.xyz/entity/paraoxonase-3-q21120463 (retrieved 2026-10-30)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 14w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → PON3
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → arylesterase activity, dihydrocoumarin hydrolase activity, 3,4-dihydrocoumarin hydrolase activity +7
    + 9 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 3.1.1.2, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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