Interferon gamma inducible protein 16

mammalian protein found in Homo sapiens

Protein protein Q21097293

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Summary

Interferon gamma inducible protein 16 is a protein^[1].

Key Facts

Molecular function: DNA-binding transcription repressor activity, RNA polymerase II-specific^[2], identical protein binding^[3], double-stranded DNA binding^[4], RNA polymerase II cis-regulatory region sequence-specific DNA binding^[5], DNA binding^[6], transcription factor binding^[7], protein binding^[8], RNA binding^[9]

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Quick Facts

Instance of protein

Properties

Biological process positive regulation of type I interferon production, positive regulation of cytokine production, intrinsic apoptotic signaling pathway by p53 class mediator, cellular response to glucose starvation, transcription, DNA-templated, negative regulation of viral genome replication, negative regulation of innate immune response, monocyte differentiation, cellular response to ionizing radiation, negative regulation of DNA binding, regulation of autophagy, myeloid cell differentiation, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, apoptotic process, hemopoiesis, activation of cysteine-type endopeptidase activity, autophagy, negative regulation of cysteine-type endopeptidase activity, negative regulation of transcription by RNA polymerase II, positive regulation of interleukin-1 beta production, regulation of transcription, DNA-templated, regulation of gene expression, epigenetic, cell population proliferation, positive regulation of transcription by RNA polymerase II, activation of innate immune response, immune system process, inflammatory response, negative regulation of transcription, DNA-templated, innate immune response, defense response to virus, activation of innate immune response, cellular response to interferon-beta

Cell component nucleolus, nucleoplasm, nucleus, membrane, nuclear speck, cytoplasm, cytosol, cytosol, membrane

Encoded by IFI16

Found in taxon Homo sapiens

Imported from wholeness_audit_2026-05-02

Molecular function DNA-binding transcription repressor activity, RNA polymerase II-specific, identical protein binding, double-stranded DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA binding, transcription factor binding, protein binding, RNA binding, RNA binding

Identifiers (4)

Ensembl protein id ENSP00000295809, ENSP00000352740, ENSP00000357113, ENSP00000357114, ENSP00000404325, ENSP00000342741, ENSP00000406406, ENSP00000407052, ENSP00000456094, ENSP00000456129, ENSP00000458084

Pdb structure id 2OQ0, 3B6Y, 3RLN, 3RLO, 3RNU, 4QGU

Refseq protein id NP_001193496, NP_005522, XP_016856639, NP_001351796, NP_001363516, NP_001363517, NP_001363518, NP_001363520, NP_001363521

Uniprot protein id Nanjing

🏷️ Also known as

en gamma-interferon-inducible protein 16 en IFI16 en IFI16 beta isoform en interferon-gamma induced protein IFI 16 en Interferon gamma inducible protein 16 en interferon-inducible myeloid differentiation transcriptional activator

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Interferon gamma inducible protein 16 — molecular function (P680): DNA-binding transcription repressor activity, RNA polymerase II-specific. Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1. Retrieved 2017-10-17. ebi.ac.uk. Provenance: wikidata.org.
[3] ↑ Interferon gamma inducible protein 16 — molecular function (P680): identical protein binding. Human Cytomegalovirus Tegument Protein pUL83 Inhibits IFI16-Mediated DNA Sensing for Immune Evasion. Retrieved 2017-10-17. ebi.ac.uk. Provenance: wikidata.org.
[4] ↑ Interferon gamma inducible protein 16 — molecular function (P680): double-stranded DNA binding. IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Interferon gamma inducible protein 16 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Interferon gamma inducible protein 16 — molecular function (P680): DNA binding. GOA. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Interferon gamma inducible protein 16 — molecular function (P680): transcription factor binding. Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Interferon gamma inducible protein 16 — molecular function (P680): protein binding. The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Interferon gamma inducible protein 16 — molecular function (P680): RNA binding. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Retrieved 2017-10-17. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Interferon gamma inducible protein 16 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). Interferon gamma inducible protein 16. Retrieved May 3, 2026, from https://4ort.xyz/entity/interferon-gamma-inducible-protein-16

MLA

“Interferon gamma inducible protein 16.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/interferon-gamma-inducible-protein-16.

BibTeX

@misc{4ortxyz_interferon-gamma-inducible-protein-16_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Interferon gamma inducible protein 16}}, year = {2026}, url = {https://4ort.xyz/entity/interferon-gamma-inducible-protein-16}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Interferon gamma inducible protein 16 — https://4ort.xyz/entity/interferon-gamma-inducible-protein-16 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/interferon-gamma-inducible-protein-16 · Last refreshed: May 3, 2026