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Integrin subunit alpha L

mammalian protein found in Homo sapiens
Protein protein Q3648604

Facts

8 properties
Instance of
protein
Part of
Integrin domain superfamily, integrin alpha chain, von Willebrand factor A-like domain superfamily, Integrin alpha, N-terminal, von Willebrand factor, type A, protein family, Integrin alpha beta-propellor, protein family, Integrin alpha-2, protein family, FG-GAP repeat, protein family, Integrin alpha chain, C-terminal cytoplasmic region, conserved site, protein family[1][2][3][4][5][6][7][8][9]
Biological process
leukocyte cell-cell adhesion, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell, extracellular matrix organization, receptor clustering, cell adhesion, regulation of immune response, integrin-mediated signaling pathway, cell-matrix adhesion, inflammatory response, leukocyte migration, signal transduction, phagocytosis, neutrophil degranulation, cell-cell adhesion, cell-cell adhesion
Cell component
integral component of membrane, integrin alphaL-beta2 complex, membrane, cell surface, integrin complex, extracellular exosome, plasma membrane, specific granule membrane, cell surface, membrane, extracellular exosome[21][22][23][24][25][26][27][28]
Encoded by
ITGAL
Found in taxon
Homo sapiens
Has part(s)
Integrin alpha-2, Integrin alpha chain, C-terminal cytoplasmic region, conserved site, FG-GAP repeat, Integrin alpha beta-propellor, von Willebrand factor, type A[10][11][12][13][14]
Molecular function
protein-containing complex binding, metal ion binding, protein binding, protein heterodimerization activity, ICAM-3 receptor activity, cell adhesion molecule binding[15][16][17][18][19][20]
🏷️ Also known as
en lymphocyte function-associated antigen 1, alpha polypeptide en antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide en CD11a Antigen en CD11 antigen-like family member A en integrin alpha-L en integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) en integrin gene promoter en Integrin subunit alpha L en ITGAL en leukocyte adhesion glycoprotein LFA-1 alpha chain en leukocyte function-associated molecule 1 alpha chain en LFA-1A en LFA-1 alpha de Integrin α-L es CD11 fa CD11a it CD11 it LFA-1α ja インテグリンαL ru CD11a

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🔗 Connections
Biological process 3
phagocytosis, signal transduction, cell adhesion
Cell component 3
plasma membrane, extracellular exosome, extracellular exosome
Found in taxon 1
Homo sapiens
Instance of 1
protein
Molecular function 1
protein binding
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References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [1] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [2] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [5] ↑ . wikidata.org.
  6. [6] ↑ . wikidata.org.
  7. [7] ↑ . wikidata.org.
  8. [8] ↑ . wikidata.org.
  9. [9] ↑ . wikidata.org.
  10. [10] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  11. [11] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  12. [12] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  13. [13] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  14. [14] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  15. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [17] ↑ . Human endothelial-cell specific molecule-1 binds directly to the integrin CD11a/CD18 (LFA-1) and blocks binding to intercellular adhesion molecule-1. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [19] ↑ . Disruption of the integrin alphaLbeta2 transmembrane domain interface by beta2 Thr-686 mutation activates alphaLbeta2 and promotes micro-clustering of the alphaL subunits. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [20] ↑ . Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [22] ↑ . Disruption of the integrin alphaLbeta2 transmembrane domain interface by beta2 Thr-686 mutation activates alphaLbeta2 and promotes micro-clustering of the alphaL subunits. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [25] ↑ . Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [26] ↑ . MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [27] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [28] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Integrin subunit alpha L. Retrieved November 3, 2026, from https://4ort.xyz/entity/integrin-subunit-alpha-l
MLA “Integrin subunit alpha L.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 Nov. 2026, https://4ort.xyz/entity/integrin-subunit-alpha-l.
BibTeX @misc{4ortxyz_integrin-subunit-alpha-l_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Integrin subunit alpha L}}, year = {2026}, url = {https://4ort.xyz/entity/integrin-subunit-alpha-l}, note = {Accessed: 2026-11-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Integrin subunit alpha L — https://4ort.xyz/entity/integrin-subunit-alpha-l (retrieved 2026-11-03)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 24w ago · InternetArchiveBot bot · 2026-05-15 view diff on Wikidata ↗
    Aliases → —
    Molecular function → protein-containing complex binding, metal ion binding, protein binding +3
    Has part(s) → Integrin alpha-2, Integrin alpha chain, C-terminal cytoplasmic region, conserved site, FG-GAP repeat +2
    Cell component → integral component of membrane, integrin alphaL-beta2 complex, membrane +8
    + 8 other properties edited (see Wikidata diff for full list)
    "/* wbsetclaim-update-references:1||1|2 */ OpenAlex ID: C62084212, Rescuing 1 sources and submitting 0 for archiving. #IABot (v2.0.9.5)"
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