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granulin precursor

mammalian protein found in Homo sapiens
Protein Q21110419

Facts

6 properties
Instance of
protein
Biological process
signal transduction, neutrophil degranulation, regulation of signaling receptor activity, positive regulation of cell migration, astrocyte activation involved in immune response, microglial cell activation involved in immune response, lysosome organization, lysosomal transport, lysosomal lumen acidification, positive regulation of endothelial cell migration, negative regulation of neuron apoptotic process, positive regulation of neuron apoptotic process, positive regulation of angiogenesis, positive regulation of axon regeneration, positive regulation of epithelial cell proliferation, protein stabilization, negative regulation of respiratory burst involved in inflammatory response, positive regulation of inflammatory response to wounding, positive regulation of defense response to bacterium, negative regulation of neutrophil activation, positive regulation of protein folding, negative regulation of microglial cell activation, positive regulation of aspartic-type peptidase activity, positive regulation of lysosome organization
Cell component
extracellular exosome, extracellular region, extracellular space, lysosome, endosome, endoplasmic reticulum, azurophil granule lumen, extracellular space, extracellular exosome, extracellular region, lysosomal membrane, late endosome, Golgi apparatus, trans-Golgi network, plasma membrane, membrane, lysosome[8][9][10]
Encoded by
GRN
Found in taxon
Homo sapiens
Molecular function
cytokine activity, growth factor activity, protein binding, RNA binding, RNA binding, chaperone binding[2][3][4][5][6][7]
🏷️ Also known as
en acrogranin en epithelin en glycoprotein 88 en glycoprotein of 88 Kda en granulin-epithelin en granulin precursor en granulins en GRN en PC cell-derived growth factor en PEPI en proepithelin en progranulin en progranulins

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Summary

granulin precursor is a protein[1].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  2. [3] ↑ . Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  3. [4] ↑ . Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  4. [5] ↑ . Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  5. [6] ↑ . Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  6. [7] ↑ . Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [8] ↑ . Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [9] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [10] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). granulin precursor. Retrieved May 3, 2026, from https://4ort.xyz/entity/granulin-precursor
MLA “granulin precursor.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/granulin-precursor.
BibTeX @misc{4ortxyz_granulin-precursor_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{granulin precursor}}, year = {2026}, url = {https://4ort.xyz/entity/granulin-precursor}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): granulin precursor — https://4ort.xyz/entity/granulin-precursor (retrieved 2026-05-03)

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