Forkhead box P3
mammalian protein found in Homo sapiens
Facts
9 properties- Instance of
- protein
- Part of
- winged helix DNA-binding domain superfamily, Winged helix-like DNA-binding domain superfamily, FOXP, coiled-coil domain, protein family, Zinc finger C2H2-type, protein family, Fork head domain, protein family, Fork head domain conserved site 2, protein family[2][3][4][5][6][7]
- Biological process
- negative regulation of cell population proliferation, negative regulation of NF-kappaB transcription factor activity, B cell homeostasis, regulation of isotype switching to IgG isotypes, myeloid cell homeostasis, negative regulation of inflammatory response, positive regulation of interleukin-4 production, regulation of immunoglobulin production, regulation of transcription by RNA polymerase II, regulation of T cell anergy, negative regulation of interleukin-6 production, tolerance induction to self antigen, regulation of transcription, DNA-templated, negative regulation of DNA-binding transcription factor activity, positive regulation of T cell tolerance induction, negative regulation of immune response, negative regulation of interferon-gamma production, tolerance induction, regulatory T cell differentiation, positive regulation of transcription, DNA-templated, negative regulation of interleukin-2 production, positive regulation of histone acetylation, negative regulation of interleukin-5 production, negative regulation of chronic inflammatory response, CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, positive regulation of transcription by RNA polymerase II, negative regulation of activated T cell proliferation, positive regulation of gene expression, negative regulation of interleukin-4 production, negative regulation of interleukin-10 production, negative regulation of tumor necrosis factor production, T cell homeostasis, negative regulation of CREB transcription factor activity, negative regulation of T-helper 17 cell differentiation, T cell activation, positive regulation of immature T cell proliferation in thymus, positive regulation of regulatory T cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of peripheral T cell tolerance induction, positive regulation of transforming growth factor beta1 production, negative regulation of transcription, DNA-templated, negative regulation of lymphocyte proliferation, negative regulation of histone acetylation, negative regulation of interleukin-17 production, response to virus, negative regulation of histone deacetylation, CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment, positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, negative regulation of T cell proliferation, chromatin remodeling, cytokine production, negative regulation of T cell cytokine production, negative regulation of isotype switching to IgE isotypes, T cell receptor signaling pathway, positive regulation of T cell anergy, transcription, DNA-templated, T cell mediated immunity, negative regulation of gene expression, anatomical structure morphogenesis, regulation of Wnt signaling pathway, regulation of regulatory T cell differentiation
- Cell component
- nucleus, intracellular anatomical structure, cytoplasm, nucleoplasm, protein-containing complex, nucleus, cytoplasm
- Encoded by
- FOXP3
- Found in taxon
- Homo sapiens
- Has part(s)
- Fork head domain, FOXP, coiled-coil domain, Zinc finger C2H2-type, Fork head domain conserved site 2[8][9][10][11]
- Has parts
- Fork head domain, FOXP, coiled-coil domain, Zinc finger C2H2-type, Fork head domain conserved site 2
- Molecular function
- sequence-specific DNA binding, NF-kappaB binding, transcription corepressor activity, nucleic acid binding, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding, protein binding, histone deacetylase binding, DNA-binding transcription factor activity, NFAT protein binding, histone acetyltransferase binding, metal ion binding, DNA binding, protein homodimerization activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific[12][13][14][15][16]
🏷️ Also known as
en immunodeficiency, polyendocrinopathy, enteropathy, X-linked
en scurfin
en Forkhead box P3
en forkhead box protein P3
en FOXP3
en FOXP3delta7
en immune dysregulation, polyendocrinopathy, enteropathy, X-linked
de Forkhead-Box-Protein P3
de FOXP3
it Forkhead box P3
🔖 Identifiers · 10
- OpenAlex ID
- C2779727006
- Image (Wikimedia Commons)
- FOXP3.png ↗
- Ensembl protein ID
- ENSP00000365372, ENSP00000365380, ENSP00000428952, ENSP00000451208, ENSP00000365369, ENSP00000396415, ENSP00000499100, ENSP00000498454, ENSP00000498236
- Exact match
- purl.uniprot.org
- Freebase ID
- /m/066764
- Microsoft Academic ID (discontinued)
- 2779727006, 2911219922
- RefSeq protein ID
- NP_001107849, NP_054728, XP_006724596, XP_016885056
- UniProt protein ID
- Q9BZS1
- WikiProjectMed ID
- FOXP3
🔗 Connections
Cell component 6
Biological process 1
Found in taxon 1
Instance of 1
Molecular function 1
← FactGrid item ID 1
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Summary
Forkhead box P3 is a protein[1].