Forkhead box O3
mammalian protein found in Homo sapiens
Facts
9 properties- Instance of
- protein
- Part of
- winged helix DNA-binding domain superfamily, Winged helix-like DNA-binding domain superfamily, FOXO protein, KIX-binding domain, FOXO protein, transactivation domain, protein family, Fork head domain, protein family, Fork head domain conserved site 2, protein family[2][3][4][5][6][7]
- Biological process
- initiation of primordial ovarian follicle growth, ovulation from ovarian follicle, regulation of transcription, DNA-templated, antral ovarian follicle growth, positive regulation of erythrocyte differentiation, glucose homeostasis, DNA damage response, signal transduction by p53 class mediator, tumor necrosis factor-mediated signaling pathway, regulation of reactive oxygen species metabolic process, transcription by RNA polymerase II, regulation of neural precursor cell proliferation, transcription, DNA-templated, neuronal stem cell population maintenance, positive regulation of neuron apoptotic process, oocyte maturation, extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of apoptotic process, regulation of translation, negative regulation of canonical Wnt signaling pathway, apoptotic process, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, cellular response to oxidative stress, positive regulation of transcription, DNA-templated, positive regulation of reactive oxygen species biosynthetic process, brain morphogenesis, ageing, negative regulation of neuron differentiation, cellular response to hypoxia, response to water-immersion restraint stress, response to nutrient levels, cellular response to amyloid-beta, cellular response to corticosterone stimulus, positive regulation of endothelial cell apoptotic process, positive regulation of hydrogen peroxide-mediated programmed cell death, response to dexamethasone, cellular response to nerve growth factor stimulus, cellular response to glucose stimulus, anatomical structure morphogenesis, cytokine-mediated signaling pathway, mitochondrial transcription, negative regulation of cell migration, negative regulation of transcription by RNA polymerase II, insulin receptor signaling pathway, glucose homeostasis, positive regulation of transcription by RNA polymerase II, positive regulation of autophagy, positive regulation of muscle atrophy, response to starvation
- Cell component
- membrane, nucleoplasm, cytosol, cytoplasm, nucleus, mitochondrion, mitochondrial outer membrane, mitochondrial matrix, protein-containing complex, nucleus, cytoplasm
- Encoded by
- FOXO3
- Found in taxon
- Homo sapiens
- Has part(s)
- Fork head domain conserved site 2, FOXO protein, transactivation domain, Fork head domain[8][9][10]
- Has parts
- Fork head domain conserved site 2, FOXO protein, transactivation domain, Fork head domain
- Molecular function
- beta-catenin binding, DNA-binding transcription activator activity, RNA polymerase II-specific, protein binding, protein kinase binding, chromatin DNA binding, DNA-binding transcription factor activity, sequence-specific DNA binding, DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, mitochondrial transcription factor activity, transcription coregulator binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor activity, transcription factor binding, sequence-specific DNA binding
🏷️ Also known as
en FOXO3
en AF6q21 protein
en Forkhead box O3
en forkhead box O3A
en forkhead box protein O3
en forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
en forkhead homolog (rhabdomyosarcoma) like 1
en forkhead in rhabdomyosarcoma-like 1
de Forkhead-Box-Protein O3
fr FOXO3A
🔖 Identifiers · 10
- OpenAlex ID
- C168003608
- Ensembl protein ID
- ENSP00000339527, ENSP00000385824, ENSP00000446316
- Freebase ID
- /m/03cvkf5
- MeSH descriptor ID
- D000071316
- MeSH tree code
- D12.776.260.950.249.125, D12.776.930.977.249.125
- Microsoft Academic ID (discontinued)
- 168003608
- RefSeq protein ID
- NP_001446, NP_963853, XP_005266924, XP_005266925, XP_011533928, XP_011533930, XP_011533931, XP_016866074, XP_016866075
- UMLS CUI
- C4255171
- UniProt protein ID
- O43524
🔗 Connections
Cell component 8
Biological process 3
Found in taxon 1
Instance of 1
Molecular function 1
Press Enter · cited answer in seconds
0 sources
Summary
Forkhead box O3 is a protein[1].