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filaggrin

mammalian protein found in Homo sapiens
Class type of: protein Q21201832

Facts

10 properties
Instance of
protein
Subclass of
protein[2]
Part of
filaggrin, EF-hand domain pair, EF-hand domain, protein family, S-100, protein family, S100/CaBP-9k-type, calcium binding, subdomain, protein family, EF-Hand 1, calcium-binding site, protein family, S100/Calbindin-D9k, conserved site, protein family[3][4][5][6][7][8][9]
Biological process
multicellular organism development, keratinocyte differentiation, establishment of skin barrier, cornification, peptide cross-linking, establishment of skin barrier
Cell component
intermediate filament, keratohyalin granule, intracellular membrane-bounded organelle, nucleus, cytosol, cornified envelope, cornified envelope, nucleus, keratohyalin granule, collagen-containing extracellular matrix
Encoded by
FLG
Found in taxon
Homo sapiens
Has part(s)
EF-hand domain, EF-hand 1, calcium-binding site, S100/Calbindin-D9k, conserved site, S100/CaBP-9k-type, calcium binding, subdomain, S-100[10][11][12][13][14]
Has parts
EF-hand domain, EF-hand 1, calcium-binding site, S100/Calbindin-D9k, conserved site, S100/CaBP-9k-type, calcium binding, subdomain, S-100
Molecular function
calcium ion binding, protein binding, structural molecule activity, metal ion binding, transition metal ion binding, structural constituent of skin epidermis, structural constituent of skin epidermis[15][16][17][18][19][20][21]
🏷️ Also known as
en epidermal filaggrin en filaggrin en FLG ar فيلاغرين de Filaggrine es Filagrina fr Profilaggrine it Filaggrina ja フィラグリン ru Филаггрин
🔖 Identifiers · 7
OpenAlex ID
C190684412
Ensembl protein ID
ENSP00000357789
Freebase ID
/m/0c3dkq
Microsoft Academic ID (discontinued)
190684412
PDB structure ID
4PCW
RefSeq protein ID
NP_002007
UniProt protein ID
P20930

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🔗 Connections
Cell component 4
nucleus, nucleus, cytosol, intermediate filament
Found in taxon 1
Homo sapiens
Has part(s) 1
EF-hand domain
Instance of 1
protein
Molecular function 1
protein binding
Subclass of 1
protein
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Summary

filaggrin is a protein[1].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . UniProt. Retrieved . wikidata.org.
  2. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [5] ↑ . wikidata.org.
  5. [6] ↑ . wikidata.org.
  6. [7] ↑ . wikidata.org.
  7. [8] ↑ . wikidata.org.
  8. [9] ↑ . wikidata.org.
  9. [10] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  10. [11] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  11. [12] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  12. [13] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  13. [14] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  14. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] ↑ . Kallikrein-related Peptidase 5 Functions in Proteolytic Processing of Profilaggrin in Cultured Human Keratinocytes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] ↑ . Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1q21. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [20] ↑ . The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [21] ↑ . The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). filaggrin. Retrieved November 2, 2026, from https://4ort.xyz/entity/filaggrin
MLA “filaggrin.” 4ort.xyz Knowledge Graph, 4ort.xyz, 2 Nov. 2026, https://4ort.xyz/entity/filaggrin.
BibTeX @misc{4ortxyz_filaggrin_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{filaggrin}}, year = {2026}, url = {https://4ort.xyz/entity/filaggrin}, note = {Accessed: 2026-11-02}}
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