cytochrome p450 oxidoreductase

mammalian protein found in Homo sapiens
Protein protein Q5201343
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Key Facts

  • Physically interacts with: Viroporin 3a[1]
  • EC enzyme number: 1.6.2.4[2]
  • Molecular function: FMN binding[3], NADPH-hemoprotein reductase activity[4], flavin adenine dinucleotide binding[5], cytochrome-b5 reductase activity, acting on NAD(P)H[6], protein binding[7], NADP binding[8], electron transfer activity[9], enzyme binding[10], oxidoreductase activity[11], iron-cytochrome-c reductase activity[12], hydrolase activity[13], nitric oxide dioxygenase activity[14]
  • Cell component: integral component of membrane[15], membrane[16], intracellular membrane-bounded organelle[17], mitochondrion[18], endoplasmic reticulum[19], endoplasmic reticulum membrane[20], cytoplasm[21], cytosol[22]
  • Biological process: regulation of growth plate cartilage chondrocyte proliferation[23], nitrate catabolic process[24], negative regulation of cysteine-type endopeptidase activity involved in apoptotic process[25], cellular response to follicle-stimulating hormone stimulus[26], positive regulation of smoothened signaling pathway[27], response to nutrient[28], demethylation[29], nitric oxide catabolic process[30], negative regulation of apoptotic process[31], positive regulation of monooxygenase activity[32], negative regulation of lipase activity[33], internal peptidyl-lysine acetylation[34], regulation of cholesterol metabolic process[35], cellular response to peptide hormone stimulus[36]
  • Encoded by: POR[37]
  • Found in taxon: Homo sapiens[38]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [1] ↑ . BioGRID. Retrieved . thebiogrid.org. Provenance: wikidata.org.
  2. [2] ↑ . UniProt. Retrieved . wikidata.org.
  3. [3] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  4. [4] ↑ . Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 A resolution. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  5. [5] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  6. [6] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [7] ↑ . Progesterone Receptor Membrane Component 1 Inhibits the Activity of Drug-Metabolizing Cytochromes P450 and Binds to Cytochrome P450 Reductase. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [8] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [9] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [10] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [11] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [12] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [22] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [27] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [28] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [29] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [30] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [31] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [32] ↑ . CYP2D6-CYP2C9 protein-protein interactions and isoform-selective effects on substrate binding and catalysis. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [33] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  34. [34] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  35. [35] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  36. [36] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  37. [37] ↑ . UniProt. Retrieved . wikidata.org.
  38. [38] ↑ . UniProt. Retrieved . wikidata.org.

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 14w ago · Boghog · 2026-07-23 view diff on Wikidata ↗
    Ec enzyme number → 1.6.2.4
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 1.6.2.4, [[:toollabs:quickstatements/#/batch/261457|batch #261457]]"
  2. 14w ago · Dirac · 2026-07-20 view diff on Wikidata ↗
    Molecular function → FMN binding, NADPH-hemoprotein reductase activity, flavin adenine dinucleotide binding +13
    Physically interacts with → Viroporin 3a
    Cell component → integral component of membrane, membrane, intracellular membrane-bounded organelle +6
    Instance of → protein
    + 6 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Image: Protein POR PDB 1amo.png, [[:toollabs:quickstatements/#/batch/261337|batch #261337]]"
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