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Cystatin C

mammalian protein found in Homo sapiens
Protein Protein Q413243

Facts

8 properties
Instance of
protein
Part of
Cystatin, cystatins, Proteinase inhibitor I25, cystatin, conserved site, protein family[2][3][4]
Biological process
negative regulation of proteolysis, defense response, negative regulation of peptidase activity, negative regulation of extracellular matrix disassembly, regulation of tissue remodeling, negative regulation of blood vessel remodeling, negative regulation of elastin catabolic process, negative regulation of collagen catabolic process, neutrophil degranulation, supramolecular fiber organization, eye development, response to hypoxia, cell activation, apoptotic process, response to oxidative stress, brain development, salivary gland development, embryo implantation, positive regulation of cell population proliferation, male gonad development, response to toxic substance, response to carbohydrate, response to inorganic substance, response to organic cyclic compound, response to nutrient levels, response to estradiol, cellular response to oxidative stress, circadian sleep/wake cycle, REM sleep, regulation of programmed cell death, post-translational protein modification, positive regulation of DNA replication, response to axon injury, Sertoli cell development, negative regulation of cell death, cellular response to hydrogen peroxide, negative regulation of cysteine-type endopeptidase activity, negative regulation of endopeptidase activity[28][29][30][31][32][33][34][35][36][37][38][39][40][41]
Cell component
extracellular region, extracellular exosome, tertiary granule lumen, ficolin-1-rich granule lumen, basement membrane, extracellular space, cytoplasm, lysosome, multivesicular body, endoplasmic reticulum, endoplasmic reticulum lumen, axon, nuclear membrane, vesicle, cell projection, soma, contractile fiber, perinuclear region of cytoplasm, extracellular space, extracellular exosome, extracellular space, endoplasmic reticulum, Golgi apparatus, plasma membrane[14][15][16][17][18][19][20][21][22][23][24][25][26][27]
Encoded by
CST3
Found in taxon
Homo sapiens
Has part(s)
Cystatin domain, Proteinase inhibitor I25, cystatin, conserved site[5][6]
Molecular function
peptidase inhibitor activity, cysteine-type endopeptidase inhibitor activity, amyloid-beta binding, protein binding, identical protein binding, endopeptidase inhibitor activity, protease binding, protease binding, peptidase inhibitor activity[7][8][9][10][11][12][13]
🏷️ Also known as
en neuroendocrine basic polypeptide en post-gamma-globulin en bA218C14.4 (cystatin C) en CST3 en cystatin 3 en Cystatin-3 en cystatin-C en Cystatin C en epididymis secretory protein Li 2 en gamma-trace ar سيستاتين سي de Cystatin es cistatina c fi kystatiini C hu Cisztatin C ja シスタチンC pl Cystatyna C ru CST3 ru Цистатин 3 ru Цистатин C
🔖 Identifiers · 14
OpenAlex ID
C2779548226
Image (Wikimedia Commons)
Crystal structure of human cystatin C monomer.png ↗
DeCS ID
53168
Ensembl protein ID
ENSP00000366124, ENSP00000381446, ENSP00000381448
Exact match
purl.uniprot.org
Freebase ID
/m/02qzgpw
MeSH descriptor ID
D055316
MeSH tree code
D12.776.215.300
Microsoft Academic ID (discontinued)
2779548226
PDB structure ID
1G96, 1R4C, 1TIJ, 3GAX, 3NX0, 3PS8, 3QRD, 3S67, 3SVA
RefSeq protein ID
NP_000090, NP_001275543
UMLS CUI
C0071744
Show all 14 identifiers +2
UniProt protein ID
P01034
YSO ID
21508

Report an error or request removal Lineage (PROV-JSON)

🔗 Connections
Cell component 15
cytoplasm, plasma membrane, endoplasmic reticulum, endoplasmic reticulum, Golgi apparatus, lysosome, axon, vesicle +7 more
Biological process 2
apoptotic process, post-translational protein modification
Found in taxon 1
Homo sapiens
Instance of 1
protein
Molecular function 1
protein binding
Part of 1
cystatins
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Summary

Cystatin C is a protein[1].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [3] ↑ . wikidata.org.
  3. [4] ↑ . wikidata.org.
  4. [5] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [6] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [7] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [8] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [9] ↑ . Cystatin C modulates cerebral beta-amyloidosis. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [10] ↑ . Megalin-mediated endocytosis of cystatin C in proximal tubule cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [11] ↑ . The pentapeptide LQVVR plays a pivotal role in human cystatin C fibrillization. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [12] ↑ . Human brain cathepsin H as a neuropeptide and bradykinin metabolizing enzyme. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [13] ↑ . Structural basis for the biological specificity of cystatin C. Identification of leucine 9 in the N-terminal binding region as a selectivity-conferring residue in the inhibition of mammalian cysteine peptidases. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] ↑ . Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [27] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [28] ↑ . Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [29] ↑ . The place of human gamma-trace (cystatin C) amongst the cysteine proteinase inhibitors. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [30] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [31] ↑ . Cystatin C deficiency in human atherosclerosis and aortic aneurysms. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [32] ↑ . Cystatin C deficiency in human atherosclerosis and aortic aneurysms. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [33] ↑ . Cystatin C deficiency in human atherosclerosis and aortic aneurysms. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [34] ↑ . Cystatin C deficiency in human atherosclerosis and aortic aneurysms. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  34. [35] ↑ . Cystatin C deficiency in human atherosclerosis and aortic aneurysms. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  35. [36] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  36. [37] ↑ . Cystatin C modulates cerebral beta-amyloidosis. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  37. [38] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  38. [39] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  39. [40] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  40. [41] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Cystatin C. Retrieved November 7, 2026, from https://4ort.xyz/entity/cystatin-c
MLA “Cystatin C.” 4ort.xyz Knowledge Graph, 4ort.xyz, 7 Nov. 2026, https://4ort.xyz/entity/cystatin-c.
BibTeX @misc{4ortxyz_cystatin-c_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Cystatin C}}, year = {2026}, url = {https://4ort.xyz/entity/cystatin-c}, note = {Accessed: 2026-11-07}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 24w ago · Twofivesixbot bot · 2026-05-19 view diff on Wikidata ↗
    Found in taxon → Homo sapiens
    Encoded by → CST3
    Cell component → extracellular region, extracellular exosome, tertiary granule lumen +1
    Biological process → negative regulation of proteolysis, defense response, negative regulation of peptidase activity +1
    + 4 other properties edited (see Wikidata diff for full list)
    "Changed claim qualifiers: YSO ID: 21508, mv to monolingual text names on YSO statements"
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