CD74 molecule

mammalian protein found in Homo sapiens

Protein protein Q21113110

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Summary

CD74 molecule is a protein^[1].

Key Facts

Part of: Thyroglobulin type-1 superfamily^[2], MHC class II-associated invariant chain, trimerisation domain superfamily^[3], MHC class II-associated invariant chain^[4], MHC class II-associated invariant chain, trimerisation, protein family^[5], Thyroglobulin type-1, protein family^[6], MHC class II-associated invariant chain/CLIP, MHC II-interacting, protein family^[7]
Has part(s): MHC class II-associated invariant chain, trimerisation^[8], MHC class II-associated invariant chain/CLIP, MHC II-interacting^[9], Thyroglobulin type-1^[10]

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MIF

Quick Facts

Instance of protein

Part of Thyroglobulin type-1 superfamily, MHC class II-associated invariant chain, trimerisation domain superfamily, MHC class II-associated invariant chain, MHC class II-associated invariant chain, trimerisation, protein family, Thyroglobulin type-1, protein family, MHC class II-associated invariant chain/CLIP, MHC II-interacting, protein family

Properties

Biological process immune response, positive regulation of T cell differentiation, negative regulation of apoptotic process, signal transduction, positive thymic T cell selection, chaperone cofactor-dependent protein refolding, T cell selection, positive regulation of type 2 immune response, positive regulation of dendritic cell antigen processing and presentation, antigen processing and presentation of exogenous peptide antigen via MHC class II, adaptive immune response, antigen processing and presentation, positive regulation of peptidyl-tyrosine phosphorylation, negative regulation of mature B cell apoptotic process, regulation of macrophage activation, negative regulation of DNA damage response, signal transduction by p53 class mediator, immunoglobulin mediated immune response, leukocyte migration, positive regulation of neutrophil chemotaxis, positive regulation of chemokine (C-X-C motif) ligand 2 production, macrophage migration inhibitory factor signaling pathway, prostaglandin biosynthetic process, cell population proliferation, antigen processing and presentation of endogenous antigen, immune system process, defense response, negative regulation of peptide secretion, negative regulation of T cell differentiation, positive regulation of macrophage cytokine production, positive regulation of B cell proliferation, negative thymic T cell selection, positive regulation of fibroblast proliferation, intracellular protein transport, positive regulation of ERK1 and ERK2 cascade, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, positive regulation of cytokine-mediated signaling pathway, positive regulation of protein phosphorylation, positive regulation of kinase activity, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of MAPK cascade, positive regulation of monocyte differentiation, positive regulation of transcription, DNA-templated, positive regulation of viral entry into host cell, protein heterotetramerization, protein trimerization, protein-containing complex assembly

Cell component lysosomal lumen, extracellular exosome, MHC class II protein complex, lysosomal membrane, late endosome, endocytic vesicle membrane, transport vesicle membrane, integral component of membrane, ER to Golgi transport vesicle membrane, multivesicular body, Golgi apparatus, Golgi membrane, trans-Golgi network membrane, macrophage migration inhibitory factor receptor complex, membrane, cell surface, intracellular anatomical structure, integral component of lumenal side of endoplasmic reticulum membrane, endoplasmic reticulum, endoplasmic reticulum membrane, plasma membrane, lysosome, vacuole, endosome, clathrin-coated endocytic vesicle membrane, NOS2-CD74 complex, external side of plasma membrane, membrane, extracellular exosome

Encoded by CD74

Found in taxon Homo sapiens

Has part(s) MHC class II-associated invariant chain, trimerisation, MHC class II-associated invariant chain/CLIP, MHC II-interacting, Thyroglobulin type-1

Has parts MHC class II-associated invariant chain, trimerisation, MHC class II-associated invariant chain/CLIP, MHC II-interacting, Thyroglobulin type-1

Molecular function nitric-oxide synthase binding, identical protein binding, MHC class II protein binding, via antigen binding groove, cytokine receptor activity, macrophage migration inhibitory factor binding, protein folding chaperone activity, MHC class II protein complex binding, amyloid-beta binding, protein binding, MHC class II protein binding, cytokine binding, CD4 receptor binding

Identifiers (9)

Ensembl protein id ENSP00000009530, ENSP00000230685, ENSP00000367026, ENSP00000429024, ENSP00000429478, ENSP00000429641, ENSP00000430614, ENSP00000430654

Exact match identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov

Freebase id /m/03cv_n2

Microsoft academic id (discontinued) 119997001

Openalex id C119997001

Pdb structure id 1A6A, 1ICF, 1IIE, 1L3H, 1MUJ, 3PDO, 3PGC, 3PGD, 3QXA, 3QXD, 4AEN, 4X5W

Refseq protein id NP_001020329, NP_001020330, NP_004346, XP_016865578, XP_016865579, NP_001351012, NP_001351013

Transporter classification database id 9.A.75.1.1

Uniprot protein id P04233

🌐 Available in 7 languages

enCD74 deCD74 faCD74 frCD74 ptCD74 ruCD74 ukCD74

🏷️ Also known as

en CD74 en CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) en CD74 molecule en CD74 molecule, major histocompatibility complex, class II invariant chain en gamma chain of class II antigens en HLA class II histocompatibility antigen gamma chain en HLA-DR antigens-associated invariant chain en HLA-DR-gamma en Ia antigen-associated invariant chain en Ia-associated invariant chain en Ii en MHC HLA-DR gamma chain en p33 zh CD74基因 zh 恒定链

🔗 Connections

Cell component 9

plasma membrane, endoplasmic reticulum, Golgi apparatus, vacuole, lysosome, endosome, extracellular exosome, extracellular exosome +1 more

Biological process 3

signal transduction, immune response, cell population proliferation

Found in taxon 1

Homo sapiens

Instance of 1

protein

Molecular function 1

protein binding

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ CD74 molecule — part of (P361): Thyroglobulin type-1 superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[3] ↑ CD74 molecule — part of (P361): MHC class II-associated invariant chain, trimerisation domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[4] ↑ CD74 molecule — part of (P361): MHC class II-associated invariant chain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ CD74 molecule — part of (P361): MHC class II-associated invariant chain, trimerisation, protein family. wikidata.org.
[6] ↑ CD74 molecule — part of (P361): Thyroglobulin type-1, protein family. wikidata.org.
[7] ↑ CD74 molecule — part of (P361): MHC class II-associated invariant chain/CLIP, MHC II-interacting, protein family. wikidata.org.
[8] ↑ CD74 molecule — has part(s) (P527): MHC class II-associated invariant chain, trimerisation. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ CD74 molecule — has part(s) (P527): MHC class II-associated invariant chain/CLIP, MHC II-interacting. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ CD74 molecule — has part(s) (P527): Thyroglobulin type-1. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ CD74 molecule is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). CD74 molecule. Retrieved October 29, 2026, from https://4ort.xyz/entity/cd74-molecule

MLA “CD74 molecule.” 4ort.xyz Knowledge Graph, 4ort.xyz, 29 Oct. 2026, https://4ort.xyz/entity/cd74-molecule.

BibTeX

@misc{4ortxyz_cd74-molecule_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{CD74 molecule}}, year = {2026}, url = {https://4ort.xyz/entity/cd74-molecule}, note = {Accessed: 2026-10-29}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): CD74 molecule — https://4ort.xyz/entity/cd74-molecule (retrieved 2026-10-29)

Canonical URL: https://4ort.xyz/entity/cd74-molecule · Last refreshed: October 29, 2026