CD14 molecule

mammalian protein found in Homo sapiens

Protein protein Q419553

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Summary

CD14 molecule is a protein^[1].

Key Facts

Part of: Leucine-rich repeat domain superfamily^[2], Monocyte differentiation antigen CD14^[3], Leucine-rich repeat, protein family^[4]
Has part(s): Leucine-rich repeat^[5]
Molecular function: lipopolysaccharide binding^[6], opsonin receptor activity^[7], lipoteichoic acid binding^[8], protein binding^[9], peptidoglycan immune receptor activity^[10]

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cluster of differentiation

glycophosphatidylinositol

Quick Facts

Instance of protein

Part of Leucine-rich repeat domain superfamily, Monocyte differentiation antigen CD14, Leucine-rich repeat, protein family

Properties

Biological process toll-like receptor TLR1:TLR2 signaling pathway, response to bacterium, toll-like receptor 4 signaling pathway, immune system process, cellular response to diacyl bacterial lipopeptide, positive regulation of interferon-gamma production, response to magnesium ion, response to heat, response to electrical stimulus, MyD88-dependent toll-like receptor signaling pathway, receptor-mediated endocytosis, cellular response to triacyl bacterial lipopeptide, TRIF-dependent toll-like receptor signaling pathway, response to tumor necrosis factor, positive regulation of endocytosis, cell surface receptor signaling pathway, response to lipopolysaccharide, cellular response to lipoteichoic acid, phagocytosis, positive regulation of tumor necrosis factor production, inflammatory response, response to ethanol, I-kappaB kinase/NF-kappaB signaling, toll-like receptor TLR6:TLR2 signaling pathway, cellular response to lipopolysaccharide, response to molecule of bacterial origin, positive regulation of type I interferon production, lipopolysaccharide-mediated signaling pathway, MyD88-independent toll-like receptor signaling pathway, apoptotic process, innate immune response, necroptosis, negative regulation of MyD88-independent toll-like receptor signaling pathway, apoptotic signaling pathway, toll-like receptor signaling pathway, neutrophil degranulation, positive regulation of NIK/NF-kappaB signaling, inflammatory response, lipopolysaccharide-mediated signaling pathway, positive regulation of interferon-gamma production, toll-like receptor 4 signaling pathway, cellular response to lipopolysaccharide, positive regulation of NIK/NF-kappaB signaling, positive regulation of type I interferon production

Cell component Golgi apparatus, membrane, plasma membrane, extracellular region, cell surface, lipopolysaccharide receptor complex, anchored component of external side of plasma membrane, membrane raft, anchored component of membrane, endosome membrane, extracellular exosome, external side of plasma membrane, extracellular space, secretory granule membrane, extracellular space, external side of plasma membrane, cell surface, membrane raft, lipopolysaccharide receptor complex, extracellular exosome

Encoded by CD14

Found in taxon Homo sapiens

Has part(s) Leucine-rich repeat

Has parts Leucine-rich repeat

Molecular function lipopolysaccharide binding, opsonin receptor activity, lipoteichoic acid binding, protein binding, peptidoglycan immune receptor activity, lipopeptide binding, lipopolysaccharide binding

Identifiers (12)

Ensembl protein id ENSP00000385519, ENSP00000304236, ENSP00000425447, ENSP00000426543, ENSP00000430884

Exact match purl.uniprot.org

Freebase id /m/09zr7h

Mesh descriptor id D018950

Mesh tree code D12.776.395.550.448.100, D12.776.543.484.500.100, D12.776.543.550.418.100, D12.776.543.750.705.045, D23.050.301.264.900.045, D23.101.100.900.045, D09.400.430.890.448.100

Microsoft academic id (discontinued) 2778513237

Openalex id C2778513237

Pdb structure id 4GLP

Refseq protein id NP_000582, NP_001035110, NP_001167575, NP_001167576

Transporter classification database id 8.A.43.1.17

Umls cui C0108768

Uniprot protein id P08571

🌐 Available in 18 languages

enCD14 arCD14 csCD14 deGlykoprotein CD14 esCD14 faCD14 frCD14 idCD14 jaCD14 koCD14 nlCD14 plCD14 ptCD14 ruCD14 trCD14 ukCD14 viCD14 zhCD14

🏷️ Also known as

en myeloid cell-specific leucine-rich glycoprotein en CD14 molecule en Lipopolysaccharide Receptors en monocyte differentiation antigen CD14 en CD14 de CD14-Rezeptor de Glykoprotein CD14 de CD14

🔗 Connections

Cell component 8

plasma membrane, Golgi apparatus, extracellular exosome, extracellular exosome, membrane raft, membrane raft, extracellular space, extracellular space

Biological process 5

apoptotic process, phagocytosis, innate immune response, necroptosis, receptor-mediated endocytosis

Found in taxon 1

Homo sapiens

Instance of 1

protein

Molecular function 1

protein binding

Part of 1

Leucine-rich repeat, protein family

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ CD14 molecule — part of (P361): Leucine-rich repeat domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[3] ↑ CD14 molecule — part of (P361): Monocyte differentiation antigen CD14. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[4] ↑ CD14 molecule — part of (P361): Leucine-rich repeat, protein family. wikidata.org.
[5] ↑ CD14 molecule — has part(s) (P527): Leucine-rich repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ CD14 molecule — molecular function (P680): lipopolysaccharide binding. Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. Retrieved 2017-09-26. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ CD14 molecule — molecular function (P680): opsonin receptor activity. Structure and function of lipopolysaccharide binding protein. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ CD14 molecule — molecular function (P680): lipoteichoic acid binding. Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ CD14 molecule — molecular function (P680): protein binding. SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ CD14 molecule — molecular function (P680): peptidoglycan immune receptor activity. CD14 is a cell-activating receptor for bacterial peptidoglycan. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ CD14 molecule is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). CD14 molecule. Retrieved October 29, 2026, from https://4ort.xyz/entity/cd14-molecule

MLA “CD14 molecule.” 4ort.xyz Knowledge Graph, 4ort.xyz, 29 Oct. 2026, https://4ort.xyz/entity/cd14-molecule.

BibTeX

@misc{4ortxyz_cd14-molecule_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{CD14 molecule}}, year = {2026}, url = {https://4ort.xyz/entity/cd14-molecule}, note = {Accessed: 2026-10-29}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): CD14 molecule — https://4ort.xyz/entity/cd14-molecule (retrieved 2026-10-29)

Canonical URL: https://4ort.xyz/entity/cd14-molecule · Last refreshed: October 29, 2026