cathepsin A

mammalian protein found in Homo sapiens
Protein protein Q423561

Facts

10 properties
Instance of
protein
Part of
Peptidase S10, serine carboxypeptidase, Alpha/Beta hydrolase fold, Serine carboxypeptidase, serine active site, protein family, Serine carboxypeptidases, histidine active site, protein family[4][5][6][7]
Biological process
regulation of protein stability, glycosphingolipid metabolic process, proteolysis, regulation of chaperone-mediated autophagy, proteolysis involved in cellular protein catabolic process, intracellular protein transport, positive regulation of catalytic activity, neutrophil degranulation, negative regulation of chaperone-mediated autophagy[27][28][29][30][31][32][33][34][35]
Cell component
membrane, intracellular membrane-bounded organelle, nucleoplasm, lysosomal lumen, endoplasmic reticulum, lysosome, lumenal side of lysosomal membrane, extracellular exosome, extracellular region, azurophil granule lumen, membrane, extracellular exosome[17][18][19][20][21][22][23][24][25][26]
EC enzyme number
3.4.16.5[10]
Encoded by
CTSA[36]
Found in taxon
Homo sapiens[37]
Has part(s)
Serine carboxypeptidases, histidine active site, Serine carboxypeptidase, serine active site[8][9]
Molecular function
peptidase activity, carboxypeptidase activity, enzyme activator activity, hydrolase activity, exo-alpha-sialidase activity, serine-type carboxypeptidase activity, serine-type carboxypeptidase activity[11][12][13][14][15][16]
🏷️ Also known as
en protective protein cathepsin A en Protective protein for beta-galactosidase en urinary kininase en beta-galactosidase 2 en beta-galactosidase protective protein en carboxypeptidase C en carboxypeptidase-L en Carboxypeptidase L en carboxypeptidase Y-like kininase en Cathepsin A en CTSA en deamidase en lysosomal carboxypeptidase A en lysosomal protective protein en PPCA de Cathepsin A de Lysosomales Schutzprotein de Serin-Carboxypeptidase A es Catepsina A ru CTSA
🔖 Identifiers · 12
OpenAlex ID
C78553746
DeCS ID
38167
Exact match
purl.uniprot.org
Freebase ID
/m/02r3wcv
MeSH descriptor ID
D043402
Microsoft Academic ID (discontinued)
78553746
PDB structure ID
1IVY, 3BP4, 3BP7, 3BXN, 4AZ0, 4AZ3, 4CI9, 4CIA, 4CIB, 4MWS, 4MWT
UMLS CUI
C0108471
UniProt protein ID
P10619

Report an error or request removal Lineage (PROV-JSON)

🔗 Connections
Cell component 5
Physically interacts with 2
← Physically interacts with 2
Biological process 1
Found in taxon 1
Instance of 1
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References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [1] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  2. [2] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  3. [3] ↑ . wikidata.org.
  4. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [5] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [6] ↑ . wikidata.org.
  7. [7] ↑ . wikidata.org.
  8. [8] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  9. [9] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  10. [10] ↑ . UniProt. Retrieved . wikidata.org.
  11. [11] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [12] ↑ . Galactosialidosis: simultaneous deficiency of esterase, carboxy-terminal deamidase and acid carboxypeptidase activities. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [13] ↑ . Galactosialidosis: a direct evidence that a 46-kilodalton protein restores deficient enzyme activities in fibroblasts. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [16] ↑ . Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [17] ↑ . Defining the membrane proteome of NK cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [21] ↑ . Human lysosomal protective protein. Glycosylation, intracellular transport, and association with beta-galactosidase in the endoplasmic reticulum. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [22] ↑ . Expression of cDNA encoding the human "protective protein" associated with lysosomal beta-galactosidase and neuraminidase: homology to yeast proteases. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [23] ↑ . Chaperone-mediated autophagy: molecular mechanisms and physiological relevance. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [24] ↑ . Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [27] ↑ . Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [28] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [29] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [30] ↑ . Chaperone-mediated autophagy: molecular mechanisms and physiological relevance. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [31] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [32] ↑ . Human lysosomal protective protein. Glycosylation, intracellular transport, and association with beta-galactosidase in the endoplasmic reticulum. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [33] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  34. [34] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  35. [35] ↑ . Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  36. [36] ↑ . UniProt. Retrieved . wikidata.org.
  37. [37] ↑ . UniProt. Retrieved . wikidata.org.

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APA 4ort.xyz Knowledge Graph. (2026). cathepsin A. Retrieved November 3, 2026, from https://4ort.xyz/entity/cathepsin-a
MLA “cathepsin A.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 Nov. 2026, https://4ort.xyz/entity/cathepsin-a.
BibTeX @misc{4ortxyz_cathepsin-a_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{cathepsin A}}, year = {2026}, url = {https://4ort.xyz/entity/cathepsin-a}, note = {Accessed: 2026-11-03}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 15w ago · Boghog · 2026-07-23 view diff on Wikidata ↗
    Instance of → —
    Part of → —
    Encoded by → CTSA
    Biological process → regulation of protein stability, glycosphingolipid metabolic process, proteolysis +6
    + 10 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ EC enzyme number: 3.4.16.5, [[:toollabs:quickstatements/#/batch/261446|batch #261446]]"
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