Caspase 5

mammalian protein found in Homo sapiens
Protein protein Q21112956

Facts

7 properties
Instance of
protein
Biological process
regulation of apoptotic process, ectopic germ cell programmed cell death, cellular response to mechanical stimulus, substantia nigra development, pyroptosis, proteolysis, regulation of inflammatory response, apoptotic process, execution phase of apoptosis, apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic process, substantia nigra development, apoptotic signaling pathway[18][19][20][21][22][23][24][25][26][27][28]
Cell component
NLRP3 inflammasome complex, AIM2 inflammasome complex, IPAF inflammasome complex, NLRP1 inflammasome complex, soma, neuron projection, cytoplasm, NLRP1 inflammasome complex[11][12][13][14][15][16][17]
EC enzyme number
3.4.22.58[1]
Encoded by
CASP5[29]
Found in taxon
Homo sapiens[30]
Molecular function
peptidase activity, cysteine-type peptidase activity, hydrolase activity, scaffold protein binding, cysteine-type endopeptidase activity involved in execution phase of apoptosis, cysteine-type endopeptidase activity involved in apoptotic process, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, protein binding[2][3][4][5][6][7][8][9][10]
🏷️ Also known as
en CASP-5 en CASP5 en caspase-5 en Caspase 5 en caspase 5, apoptosis-related cysteine peptidase en caspase 5, apoptosis-related cysteine protease en ICE(rel)-III en protease ICH-3 en protease TY en TY protease fa کاسپاز ۵ ja カスパーゼ-5 ko 캐스페이스 5 zh 胱天蛋白酶5
🔖 Identifiers · 5
Freebase ID
/m/02qxmr6
Microsoft Academic ID (discontinued)
2776068021
UniProt protein ID
P51878

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🔗 Connections
Biological process 4
Cell component 1
Found in taxon 1
Instance of 1
Molecular function 1
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References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [1] ↑ . UniProt. Retrieved . wikidata.org.
  2. [2] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  3. [3] ↑ . Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  4. [4] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  5. [5] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  6. [6] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [7] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [8] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [9] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [10] ↑ . SERPINB1-mediated checkpoint of inflammatory caspase activation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [11] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [12] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [14] ↑ . The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [17] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [20] ↑ . Expression of the Bcl-2 protein BAD promotes prostate cancer growth. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [21] ↑ . Quantitative Proteomic Analysis of Human Substantia Nigra in Alzheimer’s Disease, Huntington’s Disease and Multiple Sclerosis. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [23] ↑ . Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [25] ↑ . Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [26] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [27] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [28] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [29] ↑ . UniProt. Retrieved . wikidata.org.
  30. [30] ↑ . UniProt. Retrieved . wikidata.org.

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APA 4ort.xyz Knowledge Graph. (2026). Caspase 5. Retrieved November 3, 2026, from https://4ort.xyz/entity/caspase-5
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BibTeX @misc{4ortxyz_caspase-5_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Caspase 5}}, year = {2026}, url = {https://4ort.xyz/entity/caspase-5}, note = {Accessed: 2026-11-03}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 14w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Encoded by → CASP5
    Molecular function → peptidase activity, cysteine-type peptidase activity, hydrolase activity +7
    Found in taxon → Homo sapiens
    EC enzyme number → 3.4.22.58
    + 5 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ EC enzyme number: 3.4.22.58, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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