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Caspase 3

mammalian protein found in Homo sapiens
Protein protein Q5049057

Facts

8 properties
Instance of
protein
Biological process
cellular response to organic substance, neuron apoptotic process, cell fate commitment, response to estradiol, intracellular signal transduction, response to hypoxia, response to amino acid, apoptotic DNA fragmentation, response to organic cyclic compound, negative regulation of cyclin-dependent protein serine/threonine kinase activity, response to antibiotic, platelet formation, protein processing, response to nicotine, response to metal ion, negative regulation of cell cycle, wound healing, response to glucocorticoid, cellular response to organic cyclic compound, B cell homeostasis, negative regulation of apoptotic process, hearing, response to glucose, response to organic substance, hippo signaling, glial cell apoptotic process, keratinocyte differentiation, proteolysis, cellular response to DNA damage stimulus, T cell homeostasis, response to tumor necrosis factor, negative regulation of activated T cell proliferation, development of the heart, response to lipopolysaccharide, positive regulation of neuron apoptotic process, response to wounding, neuron differentiation, extrinsic apoptotic signaling pathway in absence of ligand, learning or memory, positive regulation of apoptotic process, erythrocyte differentiation, apoptotic signaling pathway, negative regulation of B cell proliferation, response to cobalt ion, hippocampus development, response to UV, response to X-ray, response to hydrogen peroxide, regulation of macroautophagy, neurotrophin TRK receptor signaling pathway, execution phase of apoptosis, intrinsic apoptotic signaling pathway in response to osmotic stress, cellular response to staurosporine, apoptotic process, cytokine-mediated signaling pathway, activation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of catalytic activity, luteolysis, apoptotic process, axonal fasciculation, erythrocyte differentiation, striated muscle cell differentiation, leukocyte apoptotic process, regulation of protein stability, positive regulation of amyloid-beta formation, anterior neural tube closure
Cell component
cytoplasm, cytosol, nucleoplasm, death-inducing signaling complex, membrane raft, nucleus, cytoplasm, soma
EC enzyme number
3.4.22.56[2]
Encoded by
CASP3
Found in taxon
Homo sapiens
Molecular function
cysteine-type peptidase activity, peptidase activity, protein binding, phospholipase A2 activator activity, cyclin-dependent protein serine/threonine kinase inhibitor activity, cysteine-type endopeptidase activity involved in apoptotic process, cysteine-type endopeptidase activity involved in execution phase of apoptosis, cysteine-type endopeptidase activity, hydrolase activity, cysteine-type endopeptidase activator activity involved in apoptotic process, aspartic-type endopeptidase activity, protease binding, death receptor binding, protein-containing complex binding, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, cysteine-type endopeptidase activity involved in apoptotic process, aspartic-type endopeptidase activity
Physically interacts with
emricasan[1]
🏷️ Also known as
en apopain en CASP-3 en CASP3 en caspase-3 en Caspase 3 en caspase 3, apoptosis-related cysteine peptidase en caspase 3, apoptosis-related cysteine protease en CPP-32 en cysteine protease CPP32 en PARP cleavage protease en protein Yama en SCA-1 en SREBP cleavage activity 1
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References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [1] ↑ . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  2. [2] ↑ . UniProt. Retrieved . wikidata.org.

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APA 4ort.xyz Knowledge Graph. (2026). Caspase 3. Retrieved October 30, 2026, from https://4ort.xyz/entity/caspase-3
MLA “Caspase 3.” 4ort.xyz Knowledge Graph, 4ort.xyz, 30 Oct. 2026, https://4ort.xyz/entity/caspase-3.
BibTeX @misc{4ortxyz_caspase-3_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Caspase 3}}, year = {2026}, url = {https://4ort.xyz/entity/caspase-3}, note = {Accessed: 2026-10-30}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 14w ago · Boghog · 2026-07-23 view diff on Wikidata ↗
    Physically interacts with → emricasan
    UniProt protein ID → P42574
    EC enzyme number → 3.4.22.56
    RefSeq protein ID → NP_004337, NP_116786, NP_001341706 +6
    + 13 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ EC enzyme number: 3.4.22.56, [[:toollabs:quickstatements/#/batch/261457|batch #261457]]"
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