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acrosin

mammalian protein found in Homo sapiens
Protein Protein Q413934

Facts

9 properties
Instance of
protein
Part of
peptidase S1A, acrosin, Peptidase S1, PA clan, Serine proteases, trypsin domain, protein family, Serine proteases, trypsin family, histidine active site, protein family, Serine proteases, trypsin family, serine active site, protein family[1][2][3][4][5]
Biological process
response to steroid hormone, activation of adenylate cyclase activity, proteolysis, acrosome reaction, binding of sperm to zona pellucida, acrosome matrix dispersal, single fertilization, penetration of zona pellucida, acrosome matrix dispersal, acrosome reaction, protein catabolic process[28][29][30][31][32][33][34][35][36]
Cell component
acrosomal matrix, Golgi-associated vesicle, extracellular region, acrosomal vesicle, nucleus, nucleus, protein-containing complex[22][23][24][25][26][27]
EC enzyme number
3.4.21.10[9]
Encoded by
ACR[37]
Found in taxon
Homo sapiens[38]
Has part(s)
Serine proteases, trypsin family, serine active site, serine proteases, trypsin family, histidine active site, serine proteases, trypsin domain[6][7][8]
Molecular function
DNA binding, zinc ion binding, amidase activity, peptidase activity, protein binding, mannose binding, fucose binding, serine-type peptidase activity, copper ion binding, serine-type endopeptidase activity, hydrolase activity, protease binding, serine-type endopeptidase activity[10][11][12][13][14][15][16][17][18][19][20][21]
🏷️ Also known as
en acrosin en uniprot:P10323 en proacrosin en preproacrosin en acrosin light and heavy chain prepropeptide en ACR ar أكروزين de Proakrosin de Proacrosin de Akrosin de Acrosin es Acrosina fr Acrosine ja アクロシン ko 아크로신 ru Акрозин uk ACR (ген) zh 頂體酶
🔖 Identifiers · 11
OpenAlex ID
C2777447553
Image (Wikimedia Commons)
1FIW.png ↗
DeCS ID
23150
Ensembl protein ID
ENSP00000216139, ENSP00000435120, ENSP00000490286, ENSP00000490828
Exact match
purl.uniprot.org
Freebase ID
/m/04rjh4
Microsoft Academic ID (discontinued)
2777447553
NALT ID
3125
RefSeq protein ID
NP_001088
ScienceDirect topic ID
agricultural-and-biological-sciences/acrosin
UniProt protein ID
P10323

Report an error or request removal Lineage (PROV-JSON)

🔗 Connections
Biological process 4
proteolysis, acrosome reaction, acrosome reaction, protein catabolic process
Cell component 3
nucleus, nucleus, acrosomal vesicle
Found in taxon 1
Homo sapiens
Instance of 1
protein
Molecular function 1
protein binding
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References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [1] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [2] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [3] ↑ . wikidata.org.
  4. [4] ↑ . wikidata.org.
  5. [5] ↑ . wikidata.org.
  6. [6] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  7. [7] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  8. [8] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  9. [9] ↑ . UniProt. Retrieved . wikidata.org.
  10. [10] ↑ . Acrosin, the peculiar sperm-specific serine protease. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [11] ↑ . Inhibition of human and bovine sperm acrosin by divalent metal ions. Possible role of zinc as a regulator of acrosin activity. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [12] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [14] ↑ . Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [15] ↑ . Binding of recombinant human proacrosin/acrosin to zona pellucida glycoproteins. II. Participation of mannose residues in the interaction. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [18] ↑ . Inhibition of human and bovine sperm acrosin by divalent metal ions. Possible role of zinc as a regulator of acrosin activity. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [22] ↑ . Role of acrosomal matrix proteases in sperm-zona pellucida interactions. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [26] ↑ . Proteomic characterization of the human sperm nucleus. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [27] ↑ . Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [28] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [29] ↑ . Extraction of the adenylate cyclase-activating factor of bovine sperm and its identification as a trypsin-like protease. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [30] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [31] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [32] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [33] ↑ . Functional interactions between sulphated polysaccharides and proacrosin: implications in sperm binding and digestion of zona pellucida. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  34. [34] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  35. [35] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  36. [36] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  37. [37] ↑ . UniProt. Retrieved . wikidata.org.
  38. [38] ↑ . UniProt. Retrieved . wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). acrosin. Retrieved November 9, 2026, from https://4ort.xyz/entity/acrosin
MLA “acrosin.” 4ort.xyz Knowledge Graph, 4ort.xyz, 9 Nov. 2026, https://4ort.xyz/entity/acrosin.
BibTeX @misc{4ortxyz_acrosin_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{acrosin}}, year = {2026}, url = {https://4ort.xyz/entity/acrosin}, note = {Accessed: 2026-11-09}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): acrosin — https://4ort.xyz/entity/acrosin (retrieved 2026-11-09)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 15w ago · Boghog · 2026-07-23 view diff on Wikidata ↗
    Encoded by → ACR
    Biological process → response to steroid hormone, activation of adenylate cyclase activity, proteolysis +1
    Part of → peptidase S1A, acrosin, Peptidase S1, PA clan, Serine proteases, trypsin domain, protein family +1
    EC enzyme number → 3.4.21.10
    + 5 other properties edited (see Wikidata diff for full list)
    "Created claim: EC enzyme number: 3.4.21.10, batch #261446"
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