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17α-hydroxyprogesterone

chemical compound
Class type of: progesterone congener, pregnane steroid Q175901

Facts

17 properties
Instance of
type of chemical entity
Subclass of
progesterone congener, pregnane steroid[4][5]
Part of
17alpha-hydroxyprogesterone binding, 17-alpha-hydroxyprogesterone aldolase activity, 17-hydroxyprogesterone 21-hydroxylase activity[6][7][8]
Active ingredient in
Makena[21]
Canonical SMILES
CC(=O)C1(CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C)O[2]
Chemical formula
C₂₁H₃₀O₃[3]
Defined daily dose
+10[22]
Found in taxon
Homo sapiens, Vitex agnus-castus[10][11]
Has part(s)
carbon[9]
Isomeric SMILES
CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C[13]
Mass
+330.219[14]
Medical condition treated
endometriosis, amenorrhea, uterine cancer[16][17][18]
Melting point
+219.5[15]
NCI Thesaurus ID
C87242[12]
Stylized name
HYDROXYprogesterone[23]
Subject has role
primary metabolite[20]
World Health Organisation international non-proprietary name
hydroxyprogesterone[19]
🏷️ Also known as
en Pregn-4-en-17a-ol-3,20-dione en Prodox en Prodix en 17a-Hydroxypregn-4-ene-3,20-dione en 17a-Hydroxyprogesterone en 17-alpha-Hydroxyprogesterone en 17-Hydroxypregn-4-en-3,20-dione en 17-hydroxyprogesterone en 17-OHP en 17OHP en 17-OH progesterone en 17α hydroxyprogesterone en 17α-hydroxyprogesterone en (1S,2R,10R,11S,14R,15S)-14-acetyl-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one en (8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one en (8R,9S,10R,13S,14S,17R)-17-ethanoyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one en D4-Pregnen-17a-ol-3,20-dione en delta(4)-Pregnene-17alpha-ol-3,20-dione en Gestageno en Gestageno Gador
🔖 Identifiers · 40
OpenAlex ID
C2909158248
ATC code
G03DA03
BMRB ID
bmse000472, bmse000598
CAS Registry Number
68-96-2
ChEBI ID
17252
ChEMBL ID
CHEMBL1062
ChemSpider ID
6002
DSSTOX compound identifier
DTXCID4020747
DSSTox substance ID
DTXSID6040747
DrugBank ID
DB14570
EC number
200-699-4
ECHA Substance Infocard ID
100.000.636
Show all 40 identifiers +28
Freebase ID
/m/07bp9_
Guide to Pharmacology Ligand ID
5104
HSDB ID
3343
Human Metabolome Database ID
HMDB0000374
IEDB Epitope ID
152220
InChI
InChI=1S/C21H30O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h12,16-18,24H,4-11H2,1-3H3/t16-,17+,18+,19+,20+,21+/m1/s1
InChIKey
DBPWSSGDRRHUNT-CEGNMAFCSA-N
KEGG ID
D08052
LIPID MAPS ID
LMST02030161
MassBank accession ID
MSBNK-Fac_Eng_Univ_Tokyo-JP005735
MeSH descriptor ID
D019326
MeSH tree code
D04.210.500.745.745.654.829.395.400, D06.472.334.851.687.750.478.400
Microsoft Academic ID (discontinued)
2777512201
NALT ID
1317
NDF-RT ID
N0000147872
NSC number
15468, 759566
PDB ligand ID
3QZ
PDB structure ID
3QZ1, 4NKY
Probes And Drugs ID
PD002763
PubChem CID
6238
Reaxys registry number
2062088
RxNorm CUI
5542
SPLASH
splash10-0a4j-4930000000-c5056c0aac78a148ea92, splash10-052b-9700000000-d8a942a3dfdb061bd5c3, splash10-004l-4911000000-d40ba45835d1ee1b6c41, splash10-002f-9731000000-48d2266d41955ffa9ce4, splash10-052b-5900000000-42494c0ef4b45cfa5cf4, splash10-001i-0009000000-a157e4b4aa18bdbc2531
SureChEMBL ID
8068
SwissLipids ID
SLM:000485347
UMLS CUI
C0045010, C0886627
UNII
21807M87J2
UniChem compound ID
90527

Report an error or request removal Lineage (PROV-JSON)

🔗 Connections
Medical condition treated 3
endometriosis, amenorrhea, uterine cancer
← Drug or therapy used for treatment 3
endometriosis, amenorrhea, uterine cancer
Found in taxon 2
Homo sapiens, Vitex agnus-castus
Has part(s) 1
carbon
Subclass of 1
progesterone congener
Subject has role 1
primary metabolite
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Summary

17α-hydroxyprogesterone is a type of chemical entity[1].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . PubChem. Retrieved . wikidata.org.
  2. [3] ↑ . PubChem. Retrieved . wikidata.org.
  3. [4] ↑ . NDF-RT. Retrieved . wikidata.org.
  4. [5] ↑ . wikidata.org.
  5. [6] ↑ . Gene Ontology release 2019-11-16. wikidata.org.
  6. [7] ↑ . Gene Ontology release 2020-05-02. wikidata.org.
  7. [8] ↑ . geneontology.org. Retrieved . geneontology.org. Provenance: wikidata.org.
  8. [9] ↑ . wikidata.org.
  9. [10] ↑ . Recon 2.2: from reconstruction to model of human metabolism. wikidata.org.
  10. [11] ↑ . Δ4-3-Ketosteroids in Flowers and Leaves ofVitex agnus-castus. wikidata.org.
  11. [12] ↑ . Global Substance Registration System. Retrieved . wikidata.org.
  12. [13] ↑ . Global Substance Registration System. Retrieved . wikidata.org.
  13. [14] ↑ . PubChem. Retrieved . wikidata.org.
  14. [15] ↑ . wikidata.org.
  15. [16] ↑ . NDF-RT. Retrieved . wikidata.org.
  16. [17] ↑ . NDF-RT. Retrieved . wikidata.org.
  17. [18] ↑ . NDF-RT. Retrieved . wikidata.org.
  18. [19] ↑ . ChEBI. Retrieved . wikidata.org.
  19. [20] ↑ . Reactome. reactome.org. Provenance: wikidata.org.
  20. [21] ↑ . RxNorm. Retrieved . wikidata.org.
  21. [22] ↑ . whocc.no. whocc.no. Provenance: wikidata.org.
  22. [23] ↑ . ismp.org. Retrieved . ismp.org. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). 17α-hydroxyprogesterone. Retrieved November 3, 2026, from https://4ort.xyz/entity/17-hydroxyprogesterone
MLA “17α-hydroxyprogesterone.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 Nov. 2026, https://4ort.xyz/entity/17-hydroxyprogesterone.
BibTeX @misc{4ortxyz_17-hydroxyprogesterone_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{17α-hydroxyprogesterone}}, year = {2026}, url = {https://4ort.xyz/entity/17-hydroxyprogesterone}, note = {Accessed: 2026-11-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): 17α-hydroxyprogesterone — https://4ort.xyz/entity/17-hydroxyprogesterone (retrieved 2026-11-03)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 19w ago · Nabbegat · 2026-06-19 view diff on Wikidata ↗
    Defined daily dose → {'unit': 'Q3241121', 'amount': '+10'}
    Has parts → —
    Instance of → type of chemical entity
    Part of → —
    + 12 other properties edited (see Wikidata diff for full list)
    "/* wbeditentity-update-languages-short:0||tr */ QuickStatements 3.0 [[:toollabs:qs-dev/batch/37300|batch #37300]]"
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