tolvaptan
selective, competitive vasopressin receptor 2 antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone
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Summary
tolvaptan is a type of chemical entity[1]. tolvaptan ranks in the top 5% of type of chemical entity entities by monthly Wikipedia readership (922 views/month).[2]
Key Facts
- Physically interacts with: Arginine vasopressin receptor 1A[3], Arginine vasopressin receptor 2[4]
- Canonical SMILES: CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C[5]
- Chemical formula: C₂₆H₂₅ClN₂O₃[6]
- Subclass of: chemical compound[7]
- Has use: medication[8]
- Commons category: Tolvaptan[9]
- Mass: 448.155 dalton[10]
- Medical condition treated: syndrome of Inappropriate antidiuretic hormone secretion[11], congestive heart failure[12], liver cirrhosis[13]
- Subject has role: antidiuretic hormone receptor antagonists[14]
- Pregnancy category: US pregnancy category C[15]
- Legal status (medicine): boxed warning[16]
- Active ingredient in: Jinarc[17], Samsca[18]
- Defined daily dose: 30 milligram[19]
Why It Matters
tolvaptan has Wikipedia articles in 13 language editions, a strong signal of global cultural recognition.[20] tolvaptan is known by 12 alternative names across languages and contexts.[21]