Signal transducer and activator of transcription 6

mammalian protein found in Homo sapiens

Protein protein Q7394700

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Signal transducer and activator of transcription 6

Summary

Signal transducer and activator of transcription 6 is a protein^[1].

Key Facts

Signal transducer and activator of transcription 6's instance of is recorded as protein^[2].
Signal transducer and activator of transcription 6's UniProt protein ID is recorded as P42226^[3].
Signal transducer and activator of transcription 6's part of is recorded as p53-like transcription factor, DNA-binding^[4].
Signal transducer and activator of transcription 6's part of is recorded as STAT transcription factor, DNA-binding, N-terminal^[5].
Signal transducer and activator of transcription 6's part of is recorded as transcription factor STAT^[6].
Signal transducer and activator of transcription 6's part of is recorded as STAT transcription factor, coiled coil^[7].
Signal transducer and activator of transcription 6's part of is recorded as SH2 domain superfamily^[8].
Signal transducer and activator of transcription 6's part of is recorded as STAT transcription factor, N-terminal domain superfamily^[9].
Signal transducer and activator of transcription 6's part of is recorded as STAT transcription factor, protein interaction, protein family^[10].
Signal transducer and activator of transcription 6's part of is recorded as SH2 domain, protein family^[11].
Signal transducer and activator of transcription 6's part of is recorded as STAT6, SH2 domain, protein family^[12].
Signal transducer and activator of transcription 6's part of is recorded as STAT6, C-terminal domain, protein family^[13].
Signal transducer and activator of transcription 6's part of is recorded as STAT transcription factor, DNA-binding domain, protein family^[14].
Signal transducer and activator of transcription 6's part of is recorded as STAT transcription factor, all-alpha domain, protein family^[15].
Signal transducer and activator of transcription 6's MeSH descriptor ID is recorded as D050800^[16].
Signal transducer and activator of transcription 6's has part is recorded as STAT6, C-terminal^[17].
Signal transducer and activator of transcription 6's has part is recorded as SH2 domain^[18].
Signal transducer and activator of transcription 6's has part is recorded as STAT transcription factor, all-alpha domain^[19].
Signal transducer and activator of transcription 6's has part is recorded as STAT transcription factor, DNA-binding^[20].
Signal transducer and activator of transcription 6's has part is recorded as STAT transcription factor, protein interaction^[21].
Signal transducer and activator of transcription 6's has part is recorded as STAT6, SH2 domain^[22].
Signal transducer and activator of transcription 6's RefSeq protein ID is recorded as NP_001171549^[23].
Signal transducer and activator of transcription 6's RefSeq protein ID is recorded as NP_001171550^[24].
Signal transducer and activator of transcription 6's RefSeq protein ID is recorded as NP_001171551^[25].
Signal transducer and activator of transcription 6's RefSeq protein ID is recorded as NP_001171552^[26].

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Quick Facts

Instance of protein

Part of p53-like transcription factor, DNA-binding, STAT transcription factor, DNA-binding, N-terminal, transcription factor STAT, STAT transcription factor, coiled coil, SH2 domain superfamily, STAT transcription factor, N-terminal domain superfamily, STAT transcription factor, protein interaction, protein family, SH2 domain, protein family, STAT6, SH2 domain, protein family, STAT6, C-terminal domain, protein family, STAT transcription factor, DNA-binding domain, protein family, STAT transcription factor, all-alpha domain, protein family

Properties

Biological process regulation of transcription by RNA polymerase II, T-helper 1 cell lineage commitment, regulation of cell population proliferation, response to cytokine, interleukin-4-mediated signaling pathway, regulation of transcription, DNA-templated, cellular response to hydrogen peroxide, mammary gland epithelial cell proliferation, cellular response to reactive nitrogen species, positive regulation of type I interferon production, positive regulation of isotype switching to IgE isotypes, mammary gland morphogenesis, negative regulation of type 2 immune response, negative regulation of transcription by RNA polymerase II, signal transduction, transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, cytokine-mediated signaling pathway, positive regulation of cold-induced thermogenesis, defense response, receptor signaling pathway via JAK-STAT, cytokine-mediated signaling pathway, regulation of cell population proliferation, response to peptide hormone, positive regulation of transcription by RNA polymerase II, growth hormone receptor signaling pathway via JAK-STAT

Cell component nucleus, nucleoplasm, membrane raft, cytoplasm, cytosol, nuclear membrane, nucleus, cytosol

Encoded by STAT6

Found in taxon Homo sapiens

Has part(s) STAT6, C-terminal, SH2 domain, STAT transcription factor, all-alpha domain, STAT transcription factor, DNA-binding, STAT transcription factor, protein interaction, STAT6, SH2 domain

Imported from wholeness_audit_2026-05-02

Molecular function identical protein binding, sequence-specific DNA binding, protein phosphatase binding, DNA binding, protein binding, DNA-binding transcription factor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific

External References (7)

Ensembl protein id ENSP00000451742, ENSP00000300134, ENSP00000401486, ENSP00000438451, ENSP00000444530, ENSP00000445409, ENSP00000450428, ENSP00000450510, ENSP00000450665, ENSP00000450732, ENSP00000450747, ENSP00000451074, ENSP00000451546, ENSP00000451909, ENSP00000452203, ENSP00000452373, ENSP00000452394, ENSP00000491116, ENSP00000498693

Mesh descriptor id D050800

Mesh tree code D12.644.360.024.342.600, D12.776.157.057.186.600, D12.776.476.024.430.600, D12.776.930.840.600

Pdb structure id 1OJ5, 4Y5W, 4Y5U

Refseq protein id NP_001171549, NP_001171550, NP_001171551, NP_001171552, NP_003144, XP_011537005, XP_011537006, XP_011537007, XP_011537009, XP_011537010

Umls cui C0297893

Uniprot protein id P42226

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Signal transducer and activator of transcription 6 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Signal transducer and activator of transcription 6 — UniProt protein ID (P352): P42226. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ Signal transducer and activator of transcription 6 — part of (P361): p53-like transcription factor, DNA-binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Signal transducer and activator of transcription 6 — part of (P361): STAT transcription factor, DNA-binding, N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Signal transducer and activator of transcription 6 — part of (P361): transcription factor STAT. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Signal transducer and activator of transcription 6 — part of (P361): STAT transcription factor, coiled coil. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Signal transducer and activator of transcription 6 — part of (P361): SH2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Signal transducer and activator of transcription 6 — part of (P361): STAT transcription factor, N-terminal domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Signal transducer and activator of transcription 6 — part of (P361): STAT transcription factor, protein interaction, protein family. wikidata.org.
[11] ↑ Signal transducer and activator of transcription 6 — part of (P361): SH2 domain, protein family. wikidata.org.
[12] ↑ Signal transducer and activator of transcription 6 — part of (P361): STAT6, SH2 domain, protein family. wikidata.org.
[13] ↑ Signal transducer and activator of transcription 6 — part of (P361): STAT6, C-terminal domain, protein family. wikidata.org.
[14] ↑ Signal transducer and activator of transcription 6 — part of (P361): STAT transcription factor, DNA-binding domain, protein family. wikidata.org.
[15] ↑ Signal transducer and activator of transcription 6 — part of (P361): STAT transcription factor, all-alpha domain, protein family. wikidata.org.
[16] ↑ Signal transducer and activator of transcription 6 — MeSH descriptor ID (P486): D050800. wikidata.org.
[17] ↑ Signal transducer and activator of transcription 6 — has part(s) (P527): STAT6, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Signal transducer and activator of transcription 6 — has part(s) (P527): SH2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Signal transducer and activator of transcription 6 — has part(s) (P527): STAT transcription factor, all-alpha domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Signal transducer and activator of transcription 6 — has part(s) (P527): STAT transcription factor, DNA-binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Signal transducer and activator of transcription 6 — has part(s) (P527): STAT transcription factor, protein interaction. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Signal transducer and activator of transcription 6 — has part(s) (P527): STAT6, SH2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Signal transducer and activator of transcription 6 — RefSeq protein ID (P637): NP_001171549. Q20641742. Retrieved 2020-05-30. wikidata.org.
[24] ↑ Signal transducer and activator of transcription 6 — RefSeq protein ID (P637): NP_001171550. Q20641742. Retrieved 2020-05-30. wikidata.org.
[25] ↑ Signal transducer and activator of transcription 6 — RefSeq protein ID (P637): NP_001171551. Q20641742. Retrieved 2020-05-30. wikidata.org.
[26] ↑ Signal transducer and activator of transcription 6 — RefSeq protein ID (P637): NP_001171552. Q20641742. Retrieved 2020-05-30. wikidata.org.

Class ancestry

[1] ↑ Signal transducer and activator of transcription 6 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Signal transducer and activator of transcription 6. Retrieved May 3, 2026, from https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-6-q7394700

MLA

“Signal transducer and activator of transcription 6.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-6-q7394700.

BibTeX

@misc{4ortxyz_signal-transducer-and-activator-of-transcription-6-q7394700_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Signal transducer and activator of transcription 6}}, year = {2026}, url = {https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-6-q7394700}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Signal transducer and activator of transcription 6 — https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-6-q7394700 (retrieved 2026-05-03)

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