signal transducer and activator of transcription 3

mammalian protein found in Homo sapiens

Protein protein Q4210010

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signal transducer and activator of transcription 3

Summary

signal transducer and activator of transcription 3 is a protein^[1].

Key Facts

signal transducer and activator of transcription 3's instance of is recorded as protein^[2].
signal transducer and activator of transcription 3's UniProt protein ID is recorded as P40763^[3].
signal transducer and activator of transcription 3's part of is recorded as p53-like transcription factor, DNA-binding^[4].
signal transducer and activator of transcription 3's part of is recorded as STAT transcription factor, DNA-binding, N-terminal^[5].
signal transducer and activator of transcription 3's part of is recorded as transcription factor STAT^[6].
signal transducer and activator of transcription 3's part of is recorded as STAT transcription factor, coiled coil^[7].
signal transducer and activator of transcription 3's part of is recorded as SH2 domain superfamily^[8].
signal transducer and activator of transcription 3's part of is recorded as STAT transcription factor, N-terminal domain superfamily^[9].
signal transducer and activator of transcription 3's part of is recorded as STAT transcription factor, protein interaction, protein family^[10].
signal transducer and activator of transcription 3's part of is recorded as SH2 domain, protein family^[11].
signal transducer and activator of transcription 3's part of is recorded as STAT transcription factor, DNA-binding domain, protein family^[12].
signal transducer and activator of transcription 3's part of is recorded as STAT3, SH2 domain, protein family^[13].
signal transducer and activator of transcription 3's part of is recorded as STAT transcription factor, all-alpha domain, protein family^[14].
signal transducer and activator of transcription 3's MeSH descriptor ID is recorded as D050796^[15].
signal transducer and activator of transcription 3's has part is recorded as SH2 domain^[16].
signal transducer and activator of transcription 3's has part is recorded as STAT transcription factor, all-alpha domain^[17].
signal transducer and activator of transcription 3's has part is recorded as STAT transcription factor, DNA-binding^[18].
signal transducer and activator of transcription 3's has part is recorded as STAT transcription factor, protein interaction^[19].
signal transducer and activator of transcription 3's has part is recorded as STAT3, SH2 domain^[20].
signal transducer and activator of transcription 3's RefSeq protein ID is recorded as NP_003141^[21].
signal transducer and activator of transcription 3's RefSeq protein ID is recorded as NP_644805^[22].
signal transducer and activator of transcription 3's RefSeq protein ID is recorded as NP_998827^[23].
signal transducer and activator of transcription 3's RefSeq protein ID is recorded as XP_016880462^[24].
signal transducer and activator of transcription 3's RefSeq protein ID is recorded as XP_024306664^[25].
signal transducer and activator of transcription 3's RefSeq protein ID is recorded as NP_001356441^[26].

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Quick Facts

Instance of protein

Part of p53-like transcription factor, DNA-binding, STAT transcription factor, DNA-binding, N-terminal, transcription factor STAT, STAT transcription factor, coiled coil, SH2 domain superfamily, STAT transcription factor, N-terminal domain superfamily, STAT transcription factor, protein interaction, protein family, SH2 domain, protein family, STAT transcription factor, DNA-binding domain, protein family, STAT3, SH2 domain, protein family, STAT transcription factor, all-alpha domain, protein family

Properties

Biological process negative regulation of glycolytic process, protein import into nucleus, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, response to organic substance, positive regulation of gene silencing by miRNA, radial glial cell differentiation, stem cell population maintenance, cellular response to hormone stimulus, regulation of mitochondrial membrane permeability, growth hormone receptor signaling pathway, miRNA-mediated gene silencing by inhibition of translation, eye photoreceptor cell differentiation, positive regulation of metalloendopeptidase activity, temperature homeostasis, cell population proliferation, response to leptin, response to ethanol, positive regulation of Notch signaling pathway, negative regulation of cell population proliferation, response to cytokine, regulation of transcription, DNA-templated, glucose homeostasis, negative regulation of cell death, transcription, DNA-templated, positive regulation of growth factor dependent skeletal muscle satellite cell proliferation, positive regulation of transcription, DNA-templated, negative regulation of hydrogen peroxide biosynthetic process, energy homeostasis, viral process, negative regulation of neuron death, sexual reproduction, phosphorylation, leptin-mediated signaling pathway, cellular response to organic cyclic compound, negative regulation of apoptotic process, negative regulation of transcription by RNA polymerase II, regulation of feeding behavior, nervous system development, positive regulation of ATP biosynthetic process, intracellular receptor signaling pathway, acute-phase response, negative regulation of neuron migration, receptor signaling pathway via JAK-STAT, response to estradiol, response to organic cyclic compound, eating behavior, somatic stem cell population maintenance, regulation of multicellular organism growth, ageing, response to peptide hormone, cellular response to leptin stimulus, regulation of cell cycle, astrocyte differentiation, signal transduction, positive regulation of transcription by RNA polymerase II, growth hormone receptor signaling pathway via JAK-STAT, positive regulation of gene expression, negative regulation of stem cell differentiation, positive regulation of cell population proliferation, mRNA transcription by RNA polymerase II, inflammatory response, positive regulation of erythrocyte differentiation, T-helper 17 cell lineage commitment, positive regulation of pri-miRNA transcription by RNA polymerase II, positive regulation of tyrosine phosphorylation of STAT protein, interleukin-15-mediated signaling pathway, interleukin-7-mediated signaling pathway, positive regulation of angiogenesis, positive regulation of vascular endothelial cell proliferation, cytokine-mediated signaling pathway, interleukin-21-mediated signaling pathway, interleukin-23-mediated signaling pathway, interleukin-6-mediated signaling pathway, interleukin-27-mediated signaling pathway, interleukin-35-mediated signaling pathway, cellular response to cytokine stimulus, interleukin-9-mediated signaling pathway, modulation of chemical synaptic transmission, postsynapse to nucleus signaling pathway, negative regulation of autophagy, positive regulation of cell migration, positive regulation of NF-kappaB transcription factor activity, defense response, receptor signaling pathway via JAK-STAT, cytokine-mediated signaling pathway, leptin-mediated signaling pathway, regulation of cell population proliferation, response to peptide hormone, positive regulation of transcription by RNA polymerase II, growth hormone receptor signaling pathway via JAK-STAT

Cell component cytoplasm, mitochondrion, nucleus, plasma membrane, nucleoplasm, RNA polymerase II transcription regulator complex, mitochondrial inner membrane, cytosol, postsynaptic density, Schaffer collateral - CA1 synapse, glutamatergic synapse, transcription regulator complex, nucleus, cytosol

Encoded by STAT3

Exact match purl.uniprot.org

Found in taxon Homo sapiens

Has part(s) SH2 domain, STAT transcription factor, all-alpha domain, STAT transcription factor, DNA-binding, STAT transcription factor, protein interaction, STAT3, SH2 domain

Imported from wholeness_audit_2026-05-02

Molecular function protein dimerization activity, DNA-binding transcription factor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, nuclear receptor activity, protein phosphatase binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, protein kinase binding, DNA binding, sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, chromatin DNA binding, protein homodimerization activity, identical protein binding, DNA-binding transcription factor activity, RNA polymerase II-specific, signal transducer activity, transcription factor binding, CCR5 chemokine receptor binding, glucocorticoid receptor binding, DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific

External References (8)

Ensembl protein id ENSP00000467985, ENSP00000264657, ENSP00000384943, ENSP00000467000, ENSP00000373923, ENSP00000467173

Freebase id /m/02q3lnl

Mesh descriptor id D050796

Mesh tree code D12.644.360.024.342.300, D12.776.157.057.186.300, D12.776.476.024.430.300, D12.776.930.840.300

Pdb structure id 5AX3

Refseq protein id NP_003141, NP_644805, NP_998827, XP_016880462, XP_024306664, NP_001356441, NP_001356442, NP_001356443, NP_001356445, NP_001356446, NP_001356447, NP_001356448, NP_001356449

Umls cui C0253050

Uniprot protein id P40763

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ signal transducer and activator of transcription 3 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ signal transducer and activator of transcription 3 — UniProt protein ID (P352): P40763. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ signal transducer and activator of transcription 3 — part of (P361): p53-like transcription factor, DNA-binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ signal transducer and activator of transcription 3 — part of (P361): STAT transcription factor, DNA-binding, N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ signal transducer and activator of transcription 3 — part of (P361): transcription factor STAT. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ signal transducer and activator of transcription 3 — part of (P361): STAT transcription factor, coiled coil. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ signal transducer and activator of transcription 3 — part of (P361): SH2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ signal transducer and activator of transcription 3 — part of (P361): STAT transcription factor, N-terminal domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ signal transducer and activator of transcription 3 — part of (P361): STAT transcription factor, protein interaction, protein family. wikidata.org.
[11] ↑ signal transducer and activator of transcription 3 — part of (P361): SH2 domain, protein family. wikidata.org.
[12] ↑ signal transducer and activator of transcription 3 — part of (P361): STAT transcription factor, DNA-binding domain, protein family. wikidata.org.
[13] ↑ signal transducer and activator of transcription 3 — part of (P361): STAT3, SH2 domain, protein family. wikidata.org.
[14] ↑ signal transducer and activator of transcription 3 — part of (P361): STAT transcription factor, all-alpha domain, protein family. wikidata.org.
[15] ↑ signal transducer and activator of transcription 3 — MeSH descriptor ID (P486): D050796. wikidata.org.
[16] ↑ signal transducer and activator of transcription 3 — has part(s) (P527): SH2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ signal transducer and activator of transcription 3 — has part(s) (P527): STAT transcription factor, all-alpha domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ signal transducer and activator of transcription 3 — has part(s) (P527): STAT transcription factor, DNA-binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ signal transducer and activator of transcription 3 — has part(s) (P527): STAT transcription factor, protein interaction. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ signal transducer and activator of transcription 3 — has part(s) (P527): STAT3, SH2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ signal transducer and activator of transcription 3 — RefSeq protein ID (P637): NP_003141. Q20641742. Retrieved 2020-05-30. wikidata.org.
[22] ↑ signal transducer and activator of transcription 3 — RefSeq protein ID (P637): NP_644805. Q20641742. Retrieved 2020-05-30. wikidata.org.
[23] ↑ signal transducer and activator of transcription 3 — RefSeq protein ID (P637): NP_998827. Q20641742. Retrieved 2020-05-30. wikidata.org.
[24] ↑ signal transducer and activator of transcription 3 — RefSeq protein ID (P637): XP_016880462. Q20641742. Retrieved 2020-05-30. wikidata.org.
[25] ↑ signal transducer and activator of transcription 3 — RefSeq protein ID (P637): XP_024306664. Q20641742. Retrieved 2020-05-30. wikidata.org.
[26] ↑ signal transducer and activator of transcription 3 — RefSeq protein ID (P637): NP_001356441. Q20641742. Retrieved 2020-05-30. wikidata.org.

Class ancestry

[1] ↑ signal transducer and activator of transcription 3 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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BibTeX

@misc{4ortxyz_signal-transducer-and-activator-of-transcription-3_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{signal transducer and activator of transcription 3}}, year = {2026}, url = {https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-3}, note = {Accessed: 2026-05-03}}

LLM prompt

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Canonical URL: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-3 · Last refreshed: May 3, 2026