RuvB like AAA ATPase 2

mammalian protein found in Homo sapiens

Protein protein Q21102282

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RuvB like AAA ATPase 2

Summary

RuvB like AAA ATPase 2 is a protein^[1].

Key Facts

RuvB like AAA ATPase 2's instance of is recorded as protein^[2].
RuvB like AAA ATPase 2 is part of P-loop containing nucleoside triphosphate hydrolase^[3].
RuvB like AAA ATPase 2 is part of RuvB-like helicase 2^[4].
RuvB like AAA ATPase 2 is part of AAA proteins^[5].
RuvB like AAA ATPase 2 is part of TIP49, P-loop domain, protein family^[6].
RuvB like AAA ATPase 2 comprises AAA+ ATPase domain^[7].
RuvB like AAA ATPase 2 comprises TIP49, P-loop domain^[8].
RuvB like AAA ATPase 2's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[9].
RuvB like AAA ATPase 2's molecular function is recorded as nucleotide binding^[10].
RuvB like AAA ATPase 2's molecular function is recorded as 5'-3' DNA helicase activity^[11].
RuvB like AAA ATPase 2's molecular function is recorded as helicase activity^[12].
RuvB like AAA ATPase 2's molecular function is recorded as unfolded protein binding^[13].
RuvB like AAA ATPase 2's molecular function is recorded as DNA helicase activity^[14].
RuvB like AAA ATPase 2's molecular function is recorded as DNA helicase activity^[15].
RuvB like AAA ATPase 2's molecular function is recorded as ATPase activity^[16].
RuvB like AAA ATPase 2's molecular function is recorded as protein binding^[17].
RuvB like AAA ATPase 2's molecular function is recorded as identical protein binding^[18].
RuvB like AAA ATPase 2's molecular function is recorded as chromatin DNA binding^[19].
RuvB like AAA ATPase 2's molecular function is recorded as ATP binding^[20].
RuvB like AAA ATPase 2's molecular function is recorded as hydrolase activity^[21].
RuvB like AAA ATPase 2's molecular function is recorded as RNA polymerase II core promoter sequence-specific DNA binding^[22].
RuvB like AAA ATPase 2's molecular function is recorded as TFIID-class transcription factor complex binding^[23].
RuvB like AAA ATPase 2's molecular function is recorded as protein homodimerization activity^[24].
RuvB like AAA ATPase 2's molecular function is recorded as ADP binding^[25].
RuvB like AAA ATPase 2's molecular function is recorded as ATPase binding^[26].

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Quick Facts

Instance of protein

Part of P-loop containing nucleoside triphosphate hydrolase, RuvB-like helicase 2, AAA proteins, TIP49, P-loop domain, protein family

Properties

Biological process chromatin remodeling, DNA recombination, regulation of transcription, DNA-templated, cellular response to UV, histone H2A acetylation, cellular response to estradiol stimulus, transcription, DNA-templated, positive regulation of histone acetylation, cellular response to DNA damage stimulus, establishment of protein localization to chromatin, protein folding, positive regulation of telomerase RNA localization to Cajal body, histone H4 acetylation, regulation of growth, DNA repair, positive regulation of transcription by RNA polymerase II, DNA duplex unwinding, box C/D snoRNP assembly

Cell component membrane, nuclear matrix, NuA4 histone acetyltransferase complex, intracellular anatomical structure, nucleoplasm, MLL1 complex, extracellular exosome, nucleus, Swr1 complex, R2TP complex, cytoplasm, centrosome, cytosol, Ino80 complex

Ec enzyme number 3.6.4.12

Encoded by RUVBL2

Found in taxon Homo sapiens

Has part(s) AAA+ ATPase domain, TIP49, P-loop domain

Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding, nucleotide binding, 5'-3' DNA helicase activity, helicase activity, unfolded protein binding, DNA helicase activity, DNA helicase activity, ATPase activity, protein binding, identical protein binding, chromatin DNA binding, ATP binding, hydrolase activity, RNA polymerase II core promoter sequence-specific DNA binding, TFIID-class transcription factor complex binding, protein homodimerization activity, ADP binding, ATPase binding

External References (4)

Ensembl protein id ENSP00000473172, ENSP00000221413, ENSP00000469189, ENSP00000469488, ENSP00000469760, ENSP00000471524, ENSP00000471538, ENSP00000486242, ENSP00000492564, ENSP00000492610

Pdb structure id 2CQA, 2XSZ, 3UK6

Refseq protein id NP_001308119, NP_001308120, NP_006657, XP_011524632

Uniprot protein id Q9Y230

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ RuvB like AAA ATPase 2 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ RuvB like AAA ATPase 2 — part of (P361): P-loop containing nucleoside triphosphate hydrolase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[4] ↑ RuvB like AAA ATPase 2 — part of (P361): RuvB-like helicase 2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ RuvB like AAA ATPase 2 — part of (P361): AAA proteins. wikidata.org.
[6] ↑ RuvB like AAA ATPase 2 — part of (P361): TIP49, P-loop domain, protein family. wikidata.org.
[7] ↑ RuvB like AAA ATPase 2 — has part(s) (P527): AAA+ ATPase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ RuvB like AAA ATPase 2 — has part(s) (P527): TIP49, P-loop domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ RuvB like AAA ATPase 2 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. TIP48/Reptin and H2A.Z requirement for initiating chromatin remodeling in estrogen-activated transcription. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ RuvB like AAA ATPase 2 — molecular function (P680): nucleotide binding. GOA. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ RuvB like AAA ATPase 2 — molecular function (P680): 5'-3' DNA helicase activity. GOA. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ RuvB like AAA ATPase 2 — molecular function (P680): helicase activity. GOA. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ RuvB like AAA ATPase 2 — molecular function (P680): unfolded protein binding. Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ RuvB like AAA ATPase 2 — molecular function (P680): DNA helicase activity. TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ RuvB like AAA ATPase 2 — molecular function (P680): DNA helicase activity. GOA. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ RuvB like AAA ATPase 2 — molecular function (P680): ATPase activity. Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ RuvB like AAA ATPase 2 — molecular function (P680): protein binding. CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ RuvB like AAA ATPase 2 — molecular function (P680): identical protein binding. Toward an understanding of the protein interaction network of the human liver. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ RuvB like AAA ATPase 2 — molecular function (P680): chromatin DNA binding. TIP48/Reptin and H2A.Z requirement for initiating chromatin remodeling in estrogen-activated transcription. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ RuvB like AAA ATPase 2 — molecular function (P680): ATP binding. GOA. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ RuvB like AAA ATPase 2 — molecular function (P680): hydrolase activity. GOA. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ RuvB like AAA ATPase 2 — molecular function (P680): RNA polymerase II core promoter sequence-specific DNA binding. TIP48/Reptin and H2A.Z requirement for initiating chromatin remodeling in estrogen-activated transcription. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ RuvB like AAA ATPase 2 — molecular function (P680): TFIID-class transcription factor complex binding. GOA. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ RuvB like AAA ATPase 2 — molecular function (P680): protein homodimerization activity. GOA. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ RuvB like AAA ATPase 2 — molecular function (P680): ADP binding. GOA. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ RuvB like AAA ATPase 2 — molecular function (P680): ATPase binding. GOA. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ RuvB like AAA ATPase 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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MLA

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BibTeX

@misc{4ortxyz_ruvb-like-aaa-atpase-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{RuvB like AAA ATPase 2}}, year = {2026}, url = {https://4ort.xyz/entity/ruvb-like-aaa-atpase-2}, note = {Accessed: 2026-05-03}}

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Canonical URL: https://4ort.xyz/entity/ruvb-like-aaa-atpase-2 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

1d ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Imported from → —

Encoded by → RUVBL2

Wikidata description → mammalian protein found in Homo sapiens

Molecular function → RNA polymerase II cis-regulatory region sequence-specific DNA binding, nucleotide binding, 5'-3' DNA helicase activity +15

+ 11 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 3.6.4.12, [[:toollabs:quickstatements/#/batch/261488|batch #261488]]"

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