Protein kinase C iota

mammalian protein found in Homo sapiens

Protein protein Q21109253

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Protein kinase C iota

Summary

Protein kinase C iota is a protein^[1].

Key Facts

Protein kinase C iota's instance of is recorded as protein^[2].
Protein kinase C iota's physically interacts with is recorded as staurosporine^[3].
Protein kinase C iota's physically interacts with is recorded as sotrastaurin^[4].
Protein kinase C iota's physically interacts with is recorded as gsk-690693^[5].
Protein kinase C iota is part of protein kinase C^[6].
Protein kinase C iota is part of Protein kinase-like domain superfamily^[7].
Protein kinase C iota is part of Protein kinase C, PB1 domain, protein family^[8].
Protein kinase C iota is part of Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family^[9].
Protein kinase C iota is part of Protein kinase, C-terminal domain, protein family^[10].
Protein kinase C iota is part of Atypical protein kinase C iota type, catalytic domain, protein family^[11].
Protein kinase C iota is part of PB1 domain, protein family^[12].
Protein kinase C iota is part of Diacylglycerol/phorbol-ester binding domain, protein family^[13].
Protein kinase C iota is part of AGC-kinase, C-terminal domain, protein family^[14].
Protein kinase C iota is part of Protein kinase domain, protein family^[15].
Protein kinase C iota is part of Protein kinase, ATP binding site, protein family^[16].
Protein kinase C iota is part of Serine/threonine-protein kinase, active site, protein family^[17].
Protein kinase C iota comprises AGC-kinase, C-terminal^[18].
Protein kinase C iota comprises protein kinase domain^[19].
Protein kinase C iota comprises protein kinase, ATP binding site^[20].
Protein kinase C iota comprises protein kinase, C-terminal^[21].
Protein kinase C iota comprises protein kinase C-like, phorbol ester/diacylglycerol-binding domain^[22].
Protein kinase C iota comprises PB1 domain^[23].
Protein kinase C iota comprises serine/threonine-protein kinase, active site^[24].
Protein kinase C iota comprises diacylglycerol/phorbol-ester binding^[25].
Protein kinase C iota comprises Atypical protein kinase C iota type, catalytic domain^[26].

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Quick Facts

Instance of protein

Part of protein kinase C, Protein kinase-like domain superfamily, Protein kinase C, PB1 domain, protein family, Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family, Protein kinase, C-terminal domain, protein family, Atypical protein kinase C iota type, catalytic domain, protein family, PB1 domain, protein family, Diacylglycerol/phorbol-ester binding domain, protein family, AGC-kinase, C-terminal domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Serine/threonine-protein kinase, active site, protein family

Properties

Biological process negative regulation of neuron apoptotic process, positive regulation of glucose import, establishment of apical/basal cell polarity, intracellular signal transduction, response to interleukin-1, phosphorylation, Golgi vesicle budding, actin filament organization, protein targeting to membrane, negative regulation of glial cell apoptotic process, response to peptide hormone, negative regulation of apoptotic process, secretion, protein phosphorylation, positive regulation of endothelial cell apoptotic process, positive regulation of NF-kappaB transcription factor activity, cytoskeleton organization, establishment or maintenance of epithelial cell apical/basal polarity, bicellular tight junction assembly, positive regulation of neuron projection development, cellular response to insulin stimulus, eye photoreceptor cell development, membrane organization, positive regulation of glial cell proliferation, cell migration, vesicle-mediated transport, cell-cell junction organization, peptidyl-serine phosphorylation, positive regulation of protein localization to plasma membrane, peptidyl-serine phosphorylation, positive regulation of Notch signaling pathway, regulation of postsynaptic membrane neurotransmitter receptor levels

Cell component cytosol, endosome, membrane, bicellular tight junction, microtubule cytoskeleton, Golgi membrane, plasma membrane, apical part of cell, Schmidt-Lanterman incisure, apical plasma membrane, cell leading edge, intercellular bridge, extracellular exosome, nucleus, cytoplasm, nucleoplasm, protein-containing complex, extracellular exosome, Schaffer collateral - CA1 synapse, glutamatergic synapse

Ec enzyme number 2.7.11.13

Encoded by PRKCI

Found in taxon Homo sapiens

Has part(s) AGC-kinase, C-terminal, protein kinase domain, protein kinase, ATP binding site, protein kinase, C-terminal, protein kinase C-like, phorbol ester/diacylglycerol-binding domain, PB1 domain, serine/threonine-protein kinase, active site, diacylglycerol/phorbol-ester binding, Atypical protein kinase C iota type, catalytic domain, Protein kinase C, PB1 domain

Molecular function transferase activity, protein kinase activity, nucleotide binding, protein kinase C activity, protein domain specific binding, metal ion binding, kinase activity, protein serine/threonine kinase activity, protein binding, phospholipid binding, ATP binding, protein serine/threonine kinase activity

Physically interacts with staurosporine, sotrastaurin, gsk-690693

External References (4)

Ensembl protein id ENSP00000295797

Pdb structure id 1VD2, 1WMH, 1ZRZ, 3A8W, 3A8X, 3ZH8

Refseq protein id NP_002731, XP_016862349

Uniprot protein id P41743

🏷️ Also known as

en aPKC-lambda/iota en atypical protein kinase C-lambda/iota en nPKC-iota en PRKCI en PRKC-lambda/iota en Protein kinase C iota en protein kinase C iota type

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Protein kinase C iota — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Protein kinase C iota — physically interacts with (P129): staurosporine. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ Protein kinase C iota — physically interacts with (P129): sotrastaurin. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[5] ↑ Protein kinase C iota — physically interacts with (P129): gsk-690693. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[6] ↑ Protein kinase C iota — part of (P361): protein kinase C. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Protein kinase C iota — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Protein kinase C iota — part of (P361): Protein kinase C, PB1 domain, protein family. wikidata.org.
[9] ↑ Protein kinase C iota — part of (P361): Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family. wikidata.org.
[10] ↑ Protein kinase C iota — part of (P361): Protein kinase, C-terminal domain, protein family. wikidata.org.
[11] ↑ Protein kinase C iota — part of (P361): Atypical protein kinase C iota type, catalytic domain, protein family. wikidata.org.
[12] ↑ Protein kinase C iota — part of (P361): PB1 domain, protein family. wikidata.org.
[13] ↑ Protein kinase C iota — part of (P361): Diacylglycerol/phorbol-ester binding domain, protein family. wikidata.org.
[14] ↑ Protein kinase C iota — part of (P361): AGC-kinase, C-terminal domain, protein family. wikidata.org.
[15] ↑ Protein kinase C iota — part of (P361): Protein kinase domain, protein family. wikidata.org.
[16] ↑ Protein kinase C iota — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[17] ↑ Protein kinase C iota — part of (P361): Serine/threonine-protein kinase, active site, protein family. wikidata.org.
[18] ↑ Protein kinase C iota — has part(s) (P527): AGC-kinase, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Protein kinase C iota — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Protein kinase C iota — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Protein kinase C iota — has part(s) (P527): protein kinase, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Protein kinase C iota — has part(s) (P527): protein kinase C-like, phorbol ester/diacylglycerol-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Protein kinase C iota — has part(s) (P527): PB1 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Protein kinase C iota — has part(s) (P527): serine/threonine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Protein kinase C iota — has part(s) (P527): diacylglycerol/phorbol-ester binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Protein kinase C iota — has part(s) (P527): Atypical protein kinase C iota type, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Protein kinase C iota is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Protein kinase C iota. Retrieved May 3, 2026, from https://4ort.xyz/entity/protein-kinase-c-iota-q21109253

MLA

“Protein kinase C iota.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/protein-kinase-c-iota-q21109253.

BibTeX

@misc{4ortxyz_protein-kinase-c-iota-q21109253_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Protein kinase C iota}}, year = {2026}, url = {https://4ort.xyz/entity/protein-kinase-c-iota-q21109253}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Protein kinase C iota — https://4ort.xyz/entity/protein-kinase-c-iota-q21109253 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/protein-kinase-c-iota-q21109253 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

5w ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Imported from → —

Encoded by → PRKCI

Wikidata description → mammalian protein found in Homo sapiens

Molecular function → transferase activity, protein kinase activity, nucleotide binding +9

+ 12 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.7.11.13, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"

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