Phosphodiesterase 4D

mammalian protein found in Homo sapiens

Protein protein Q21106795

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Phosphodiesterase 4D

Summary

Phosphodiesterase 4D is a protein^[1].

Key Facts

Phosphodiesterase 4D's instance of is recorded as protein^[2].
Phosphodiesterase 4D's physically interacts with is recorded as rolipram^[3].
Phosphodiesterase 4D is part of 3'5'-cyclic nucleotide phosphodiesterase^[4].
Phosphodiesterase 4D is part of 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily^[5].
Phosphodiesterase 4D is part of 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family^[6].
Phosphodiesterase 4D is part of HD/PDEase domain, protein family^[7].
Phosphodiesterase 4D is part of 3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family^[8].
Phosphodiesterase 4D comprises 3'5'-cyclic nucleotide phosphodiesterase, conserved site^[9].
Phosphodiesterase 4D comprises 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain^[10].
Phosphodiesterase 4D comprises HD/PDEase domain^[11].
Phosphodiesterase 4D's molecular function is recorded as ATPase binding^[12].
Phosphodiesterase 4D's molecular function is recorded as scaffold protein binding^[13].
Phosphodiesterase 4D's molecular function is recorded as cAMP binding^[14].
Phosphodiesterase 4D's molecular function is recorded as metal ion binding^[15].
Phosphodiesterase 4D's molecular function is recorded as beta-2 adrenergic receptor binding^[16].

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Quick Facts

Instance of protein

Part of 3'5'-cyclic nucleotide phosphodiesterase, 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily, 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family, HD/PDEase domain, protein family, 3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family

Properties

Biological process establishment of endothelial barrier, smooth muscle contraction, positive regulation of interleukin-5 production, multicellular organism growth, ageing, regulation of signaling receptor activity, positive regulation of interferon-gamma production, neutrophil chemotaxis, positive regulation of interleukin-2 production, regulation of cell communication by electrical coupling involved in cardiac conduction, adrenergic receptor signaling pathway, cellular response to lipopolysaccharide, T cell receptor signaling pathway, adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate, cAMP-mediated signaling, cellular response to cAMP, signal transduction, leukocyte migration, negative regulation of relaxation of cardiac muscle, regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, negative regulation of heart contraction, regulation of heart rate, regulation of ryanodine-sensitive calcium-release channel activity, cAMP catabolic process, cellular response to epinephrine stimulus, regulation of cardiac muscle cell contraction, negative regulation of peptidyl-serine phosphorylation, G protein-coupled receptor signaling pathway, cAMP catabolic process, cAMP catabolic process, negative regulation of cAMP-mediated signaling, cAMP catabolic process, cellular response to epinephrine stimulus, cAMP catabolic process, negative regulation of cAMP-mediated signaling, regulation of cardiac muscle cell contraction

Cell component cytoplasm, cytosol, centrosome, microtubule organizing center, apical plasma membrane, cytoskeleton, membrane, calcium channel complex, voltage-gated calcium channel complex, plasma membrane, nuclear membrane, membrane, centrosome, cytosol

Ec enzyme number 3.1.4.53

Encoded by PDE4D

Exact match identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov

Found in taxon Homo sapiens

Has part(s) 3'5'-cyclic nucleotide phosphodiesterase, conserved site, 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, HD/PDEase domain

Molecular function ATPase binding, scaffold protein binding, cAMP binding, metal ion binding, beta-2 adrenergic receptor binding, protein binding, phosphoric diester hydrolase activity, enzyme binding, hydrolase activity, ubiquitin protein ligase binding, transmembrane transporter binding, 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, 3',5'-cyclic-AMP phosphodiesterase activity, protein binding, transmembrane transporter binding, ATPase binding

Physically interacts with rolipram

External References (4)

Ensembl protein id ENSP00000308485, ENSP00000321739, ENSP00000345502, ENSP00000351800, ENSP00000353152, ENSP00000384806, ENSP00000423094, ENSP00000424852, ENSP00000425605, ENSP00000425917, ENSP00000421013, ENSP00000421829, ENSP00000423555, ENSP00000424281, ENSP00000425910, ENSP00000442734, ENSP00000490821, ENSP00000492052

Pdb structure id 1MKD, 1OYN, 1PTW, 1Q9M, 1TB7, 1TBB, 1XOM, 1XON, 1XOQ, 1XOR, 1Y2B, 1Y2C, 1Y2D, 1Y2E, 1Y2K, 1ZKN, 2FM0, 2FM5, 2PW3, 2QYN, 3G4G, 3G4I, 3G4K, 3G4L, 3G58, 3IAD, 3IAK, 3K4S, 3SL3, 3SL4, 3SL5, 3SL6, 3SL8, 3V9B, 4OGB, 4W1O, 4WCU

Refseq protein id NP_001098101, NP_001159371, NP_001184147, NP_001184148, NP_001184149, NP_001184150, NP_001184151, NP_001184152, NP_006194, XP_011541771, XP_011541772, XP_011541773, XP_011541775, XP_016865054, XP_016865055, XP_016865056, NP_001336170, NP_001336171, NP_001336172, XP_024301878, XP_024301880, NP_001351528, NP_001351529, NP_001351530, NP_001351531, NP_001351532, NP_001351533

Uniprot protein id Q08499

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Phosphodiesterase 4D — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Phosphodiesterase 4D — physically interacts with (P129): rolipram. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ Phosphodiesterase 4D — part of (P361): 3'5'-cyclic nucleotide phosphodiesterase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Phosphodiesterase 4D — part of (P361): 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Phosphodiesterase 4D — part of (P361): 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family. wikidata.org.
[7] ↑ Phosphodiesterase 4D — part of (P361): HD/PDEase domain, protein family. wikidata.org.
[8] ↑ Phosphodiesterase 4D — part of (P361): 3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family. wikidata.org.
[9] ↑ Phosphodiesterase 4D — has part(s) (P527): 3'5'-cyclic nucleotide phosphodiesterase, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Phosphodiesterase 4D — has part(s) (P527): 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Phosphodiesterase 4D — has part(s) (P527): HD/PDEase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Phosphodiesterase 4D — molecular function (P680): ATPase binding. Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca 2+ Release and Cardiac Contractility, Independently of L-Type Ca 2+ Current. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Phosphodiesterase 4D — molecular function (P680): scaffold protein binding. PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Phosphodiesterase 4D — molecular function (P680): cAMP binding. Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Phosphodiesterase 4D — molecular function (P680): metal ion binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Phosphodiesterase 4D — molecular function (P680): beta-2 adrenergic receptor binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Phosphodiesterase 4D is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). Phosphodiesterase 4D. Retrieved May 3, 2026, from https://4ort.xyz/entity/phosphodiesterase-4d

MLA

“Phosphodiesterase 4D.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/phosphodiesterase-4d.

BibTeX

@misc{4ortxyz_phosphodiesterase-4d_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Phosphodiesterase 4D}}, year = {2026}, url = {https://4ort.xyz/entity/phosphodiesterase-4d}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Phosphodiesterase 4D — https://4ort.xyz/entity/phosphodiesterase-4d (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/phosphodiesterase-4d · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

7d ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Imported from → —

Encoded by → PDE4D

Wikidata description → mammalian protein found in Homo sapiens

Molecular function → ATPase binding, scaffold protein binding, cAMP binding +14

+ 13 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 3.1.4.53, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"

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