Nuclear receptor coactivator 1

mammalian protein found in Homo sapiens

Protein protein Q3681842

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Nuclear receptor coactivator 1

Summary

Nuclear receptor coactivator 1 is a protein^[1].

Key Facts

Nuclear receptor coactivator 1's instance of is recorded as protein^[2].
Nuclear receptor coactivator 1 is part of PAS domain superfamily^[3].
Nuclear receptor coactivator 1 is part of Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily^[4].
Nuclear receptor coactivator 1 is part of nuclear receptor coactivator 1^[5].
Nuclear receptor coactivator 1 is part of Nuclear receptor coactivator, interlocking^[6].
Nuclear receptor coactivator 1 is part of Helix-loop-helix DNA-binding domain superfamily^[7].
Nuclear receptor coactivator 1 is part of Myc-type, basic helix-loop-helix (bHLH) domain, protein family^[8].
Nuclear receptor coactivator 1 is part of Nuclear receptor coactivator, receptor-binding domain, protein family^[9].
Nuclear receptor coactivator 1 is part of PAS fold family^[10].
Nuclear receptor coactivator 1 is part of Nuclear receptor coactivator, Ncoa-type, interlocking, protein family^[11].
Nuclear receptor coactivator 1 is part of Domain of unknown function DUF1518, protein family^[12].
Nuclear receptor coactivator 1 is part of PAS domain, protein family^[13].
Nuclear receptor coactivator 1 comprises PAS fold^[14].
Nuclear receptor coactivator 1 comprises PAS domain^[15].
Nuclear receptor coactivator 1 comprises Myc-type, basic helix-loop-helix (bHLH) domain^[16].
Nuclear receptor coactivator 1 comprises Domain of unknown function DUF1518^[17].
Nuclear receptor coactivator 1 comprises Nuclear receptor coactivator, Ncoa-type, interlocking^[18].
Nuclear receptor coactivator 1 comprises Nuclear receptor coactivator, receptor-binding domain^[19].

⭐ Popularity Graph

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Quick Facts

Instance of protein

Part of PAS domain superfamily, Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily, nuclear receptor coactivator 1, Nuclear receptor coactivator, interlocking, Helix-loop-helix DNA-binding domain superfamily, Myc-type, basic helix-loop-helix (bHLH) domain, protein family, Nuclear receptor coactivator, receptor-binding domain, protein family, PAS fold family, Nuclear receptor coactivator, Ncoa-type, interlocking, protein family, Domain of unknown function DUF1518, protein family, PAS domain, protein family

Properties

Biological process androgen receptor signaling pathway, regulation of RNA biosynthetic process, regulation of transcription, DNA-templated, cellular response to Thyroglobulin triiodothyronine, regulation of cellular response to drug, transcription, DNA-templated, positive regulation of transcription, DNA-templated, labyrinthine layer morphogenesis, positive regulation of neuron differentiation, bile acid and bile salt transport, positive regulation of apoptotic process, histone H4 acetylation, regulation of thyroid hormone mediated signaling pathway, positive regulation of transcription by RNA polymerase II, intracellular receptor signaling pathway, positive regulation of transcription from RNA polymerase II promoter by galactose, regulation of lipid metabolic process, transcription by RNA polymerase II, cellular response to hormone stimulus, transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, lactation, male gonad development, response to hormone, cerebellum development, hippocampus development, hypothalamus development, cerebral cortex development, response to estradiol, response to retinoic acid, response to progesterone, cellular response to hormone stimulus, estrous cycle, positive regulation of female receptivity, male mating behavior

Cell component nucleus, nucleoplasm, cytosol, plasma membrane, protein-containing complex, nucleus, cytoplasm, neuron projection

Ec enzyme number 2.3.1.48

Encoded by NCOA1

Found in taxon Homo sapiens

Has part(s) PAS fold, PAS domain, Myc-type, basic helix-loop-helix (bHLH) domain, Domain of unknown function DUF1518, Nuclear receptor coactivator, Ncoa-type, interlocking, Nuclear receptor coactivator, receptor-binding domain

Molecular function transferase activity, DNA binding, transcription coactivator activity, protein dimerization activity, protein N-terminus binding, transcription coactivator activity, transcription factor binding, chromatin binding, histone acetyltransferase activity, protein binding, androgen receptor binding, enzyme binding, acyltransferase activity, nuclear receptor coactivator activity, aryl hydrocarbon receptor binding, nuclear receptor binding, estrogen receptor binding, DNA-binding transcription factor activity, RNA polymerase II-specific, nuclear receptor binding, nuclear receptor coactivator activity, nuclear receptor binding, estrogen receptor binding, progesterone receptor binding, retinoic acid receptor binding, protein-containing complex binding, retinoid X receptor binding

External References (5)

Ensembl protein id ENSP00000288599, ENSP00000320940, ENSP00000379197, ENSP00000385097, ENSP00000385216, ENSP00000385195

Freebase id /m/02ryks5

Pdb structure id 1FM6, 1FM9, 1K74, 1K7L, 1KV6, 1K4W, 1N4H, 1NQ7, 1NRL, 1P8D, 1PZL, 1RDT, 1TFC, 1U3R, 1U3S, 1X76, 1XIU, 1XV9, 1XVP, 1YY4, 1ZAF, 2A3I, 2C52, 2FVJ, 2GTK, 2HBH, 2HC4, 2HCD, 2HFP, 2NPA, 2NV7, 2P54, 2PRG, 3BEJ, 3BQD, 3CTB, 3CWD, 3DCT, 3DCU, 3DR1, 3ET1, 3ET3, 3FEI, 3FEJ, 3FUR, 3FXV, 3G8I, 3G9E, 3GYT, 3GYU, 3H0A, 3HC5, 3HC6, 3HVL, 3IPQ, 3IPS, 3IPU, 3KMR, 3LMP, 3OKH, 3OKI, 3OLF, 3OLL, 3OLS, 3OMK, 3OMM, 3OMO, 3OMP, 3OMQ, 3OOF, 3OOK, 3P88, 3P89, 3QT0, 3RUT, 3RUU, 3RVF, 3S9S, 3T03, 3UU7, 3UUA, 3UUD, 3V9Y, 3VN2, 4DK7, 4DK8, 4DM6, 4DM8, 4DQM, 4F9M, 4FGY, 4G1D, 4G1Y, 4G1Z, 4G20, 4G21, 4G2H, 4HEE, 4J5X, 4JYG, 4JYH, 4JYI, 4MG5, 4MG6, 4MG7, 4MG8, 4MG9, 4MGA, 4MGB, 4MGC, 4MGD, 4TUZ, 4TV1, 5AVI, 5AVL, 4Y29, 4RUJ, 4RUP, 5A86, 5E7V, 4UDB, 4UDA, 5AZT, 5HJS

Refseq protein id NP_003734, NP_671756, NP_671766, XP_005264682, XP_005264683, NP_001349879, NP_001349881, NP_001349883, NP_001349884

Uniprot protein id ruble

🏷️ Also known as

en bHLHe74 en class E basic helix-loop-helix protein 74 en Hin-2 protein en NCOA1 en Nuclear receptor coactivator 1 en PAX3/NCOA1 fusion protein en Protein Hin-2 en renal carcinoma antigen NY-REN-52 en RIP160 en SRC-1 en steroid receptor coactivator-1 en Steroid receptor coactivator 1 it Coattivatore del recettore nucleare 1

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Nuclear receptor coactivator 1 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Nuclear receptor coactivator 1 — part of (P361): PAS domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[4] ↑ Nuclear receptor coactivator 1 — part of (P361): Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Nuclear receptor coactivator 1 — part of (P361): nuclear receptor coactivator 1. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Nuclear receptor coactivator 1 — part of (P361): Nuclear receptor coactivator, interlocking. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Nuclear receptor coactivator 1 — part of (P361): Helix-loop-helix DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Nuclear receptor coactivator 1 — part of (P361): Myc-type, basic helix-loop-helix (bHLH) domain, protein family. wikidata.org.
[9] ↑ Nuclear receptor coactivator 1 — part of (P361): Nuclear receptor coactivator, receptor-binding domain, protein family. wikidata.org.
[10] ↑ Nuclear receptor coactivator 1 — part of (P361): PAS fold family. wikidata.org.
[11] ↑ Nuclear receptor coactivator 1 — part of (P361): Nuclear receptor coactivator, Ncoa-type, interlocking, protein family. wikidata.org.
[12] ↑ Nuclear receptor coactivator 1 — part of (P361): Domain of unknown function DUF1518, protein family. wikidata.org.
[13] ↑ Nuclear receptor coactivator 1 — part of (P361): PAS domain, protein family. wikidata.org.
[14] ↑ Nuclear receptor coactivator 1 — has part(s) (P527): PAS fold. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Nuclear receptor coactivator 1 — has part(s) (P527): PAS domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Nuclear receptor coactivator 1 — has part(s) (P527): Myc-type, basic helix-loop-helix (bHLH) domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Nuclear receptor coactivator 1 — has part(s) (P527): Domain of unknown function DUF1518. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Nuclear receptor coactivator 1 — has part(s) (P527): Nuclear receptor coactivator, Ncoa-type, interlocking. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Nuclear receptor coactivator 1 — has part(s) (P527): Nuclear receptor coactivator, receptor-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Nuclear receptor coactivator 1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Nuclear receptor coactivator 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/nuclear-receptor-coactivator-1

MLA

“Nuclear receptor coactivator 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/nuclear-receptor-coactivator-1.

BibTeX

@misc{4ortxyz_nuclear-receptor-coactivator-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Nuclear receptor coactivator 1}}, year = {2026}, url = {https://4ort.xyz/entity/nuclear-receptor-coactivator-1}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Nuclear receptor coactivator 1 — https://4ort.xyz/entity/nuclear-receptor-coactivator-1 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/nuclear-receptor-coactivator-1 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

5w ago · Boghog · 2026-07-23 view diff on Wikidata ↗

Uniprot protein id → ruble

Ec enzyme number → 2.3.1.48

Refseq protein id → NP_003734, NP_671756, NP_671766 +6

Imported from → —

+ 13 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.3.1.48, [[:toollabs:quickstatements/#/batch/261446|batch #261446]]"

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