MRE11 homolog, double strand break repair nuclease

mammalian protein found in Homo sapiens

Protein protein Q2073928

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MRE11 homolog, double strand break repair nuclease

Summary

MRE11 homolog, double strand break repair nuclease is a protein^[1].

Key Facts

MRE11 homolog, double strand break repair nuclease's instance of is recorded as protein^[2].
MRE11 homolog, double strand break repair nuclease's UniProt protein ID is recorded as P49959^[3].
MRE11 homolog, double strand break repair nuclease's part of is recorded as DNA double-strand break repair protein Mre11^[4].
MRE11 homolog, double strand break repair nuclease's part of is recorded as Metallo-dependent phosphatase-like^[5].
MRE11 homolog, double strand break repair nuclease's part of is recorded as Mre11, DNA-binding domain superfamily^[6].
MRE11 homolog, double strand break repair nuclease's part of is recorded as Mre11, DNA-binding domain, protein family^[7].
MRE11 homolog, double strand break repair nuclease's part of is recorded as Calcineurin-like phosphoesterase^[8].
MRE11 homolog, double strand break repair nuclease's has part is recorded as Mre11, DNA-binding^[9].
MRE11 homolog, double strand break repair nuclease's has part is recorded as Calcineurin-like phosphoesterase domain, ApaH type^[10].
MRE11 homolog, double strand break repair nuclease's RefSeq protein ID is recorded as NP_001317276^[11].
MRE11 homolog, double strand break repair nuclease's RefSeq protein ID is recorded as NP_005581^[12].
MRE11 homolog, double strand break repair nuclease's RefSeq protein ID is recorded as NP_005582^[13].
MRE11 homolog, double strand break repair nuclease's RefSeq protein ID is recorded as XP_005274065^[14].
MRE11 homolog, double strand break repair nuclease's RefSeq protein ID is recorded as XP_006718905^[15].
MRE11 homolog, double strand break repair nuclease's RefSeq protein ID is recorded as XP_011541139^[16].
MRE11 homolog, double strand break repair nuclease's RefSeq protein ID is recorded as XP_016873261^[17].
MRE11 homolog, double strand break repair nuclease's PDB structure ID is recorded as 3T1I^[18].
MRE11 homolog, double strand break repair nuclease's molecular function is recorded as DNA binding^[19].
MRE11 homolog, double strand break repair nuclease's molecular function is recorded as manganese ion binding^[20].
MRE11 homolog, double strand break repair nuclease's molecular function is recorded as DNA helicase activity^[21].
MRE11 homolog, double strand break repair nuclease's molecular function is recorded as single-stranded DNA endodeoxyribonuclease activity^[22].
MRE11 homolog, double strand break repair nuclease's molecular function is recorded as protein C-terminus binding^[23].
MRE11 homolog, double strand break repair nuclease's molecular function is recorded as protein binding^[24].
MRE11 homolog, double strand break repair nuclease's molecular function is recorded as 3'-5' exonuclease activity^[25].
MRE11 homolog, double strand break repair nuclease's molecular function is recorded as nuclease activity^[26].

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Quick Facts

Instance of protein

Part of DNA double-strand break repair protein Mre11, Metallo-dependent phosphatase-like, Mre11, DNA-binding domain superfamily, Mre11, DNA-binding domain, protein family, Calcineurin-like phosphoesterase

Properties

Biological process reciprocal meiotic recombination, DNA recombination, telomere maintenance via telomerase, positive regulation of kinase activity, mitotic intra-S DNA damage checkpoint signaling, telomeric 3' overhang formation, negative regulation of apoptotic process, chromosome organization, sister chromatid cohesion, cellular response to DNA damage stimulus, positive regulation of telomere maintenance, DNA duplex unwinding, homologous chromosome pairing at meiosis, negative regulation of DNA endoreduplication, double-strand break repair, meiosis, double-strand break repair via homologous recombination, positive regulation of protein autophosphorylation, cell population proliferation, mitotic G2 DNA damage checkpoint signaling, viral process, double-strand break repair via nonhomologous end joining, positive regulation of type I interferon production, regulation of mitotic recombination, DNA repair, nucleic acid phosphodiester bond hydrolysis, DNA double-strand break processing, strand displacement, DNA replication, DNA synthesis involved in DNA repair, regulation of signal transduction by p53 class mediator, telomere maintenance, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, sister chromatid cohesion, mitotic G2 DNA damage checkpoint signaling, meiotic DNA double-strand break formation, mitochondrial double-strand break repair via homologous recombination, DNA strand resection involved in replication fork processing

Cell component site of double-strand break, cytosol, PML body, nucleus, cytoplasm, nucleoplasm, telomere, chromosome, Mre11 complex, replication fork

Encoded by MRE11

Found in taxon Homo sapiens

Has part(s) Mre11, DNA-binding, Calcineurin-like phosphoesterase domain, ApaH type

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, manganese ion binding, DNA helicase activity, single-stranded DNA endodeoxyribonuclease activity, protein C-terminus binding, protein binding, 3'-5' exonuclease activity, nuclease activity, endonuclease activity, double-stranded DNA binding, endodeoxyribonuclease activity, exonuclease activity, hydrolase activity, cadherin binding, identical protein binding, 3'-5'-exodeoxyribonuclease activity, 3'-5' exonuclease activity, 5'-3' exonuclease activity, cadherin binding

External References (4)

Ensembl protein id ENSP00000325863, ENSP00000326094, ENSP00000385614, ENSP00000376933, ENSP00000439511, ENSP00000440986, ENSP00000442809

Pdb structure id 3T1I

Refseq protein id NP_001317276, NP_005581, NP_005582, XP_005274065, XP_006718905, XP_011541139, XP_016873261

Uniprot protein id P49959

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ MRE11 homolog, double strand break repair nuclease — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ MRE11 homolog, double strand break repair nuclease — UniProt protein ID (P352): P49959. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ MRE11 homolog, double strand break repair nuclease — part of (P361): DNA double-strand break repair protein Mre11. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ MRE11 homolog, double strand break repair nuclease — part of (P361): Metallo-dependent phosphatase-like. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ MRE11 homolog, double strand break repair nuclease — part of (P361): Mre11, DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ MRE11 homolog, double strand break repair nuclease — part of (P361): Mre11, DNA-binding domain, protein family. wikidata.org.
[8] ↑ MRE11 homolog, double strand break repair nuclease — part of (P361): Calcineurin-like phosphoesterase. wikidata.org.
[9] ↑ MRE11 homolog, double strand break repair nuclease — has part(s) (P527): Mre11, DNA-binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ MRE11 homolog, double strand break repair nuclease — has part(s) (P527): Calcineurin-like phosphoesterase domain, ApaH type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ MRE11 homolog, double strand break repair nuclease — RefSeq protein ID (P637): NP_001317276. Q20641742. Retrieved 2020-05-30. wikidata.org.
[12] ↑ MRE11 homolog, double strand break repair nuclease — RefSeq protein ID (P637): NP_005581. Q20641742. Retrieved 2020-05-30. wikidata.org.
[13] ↑ MRE11 homolog, double strand break repair nuclease — RefSeq protein ID (P637): NP_005582. Q20641742. Retrieved 2020-05-30. wikidata.org.
[14] ↑ MRE11 homolog, double strand break repair nuclease — RefSeq protein ID (P637): XP_005274065. Q20641742. Retrieved 2020-05-30. wikidata.org.
[15] ↑ MRE11 homolog, double strand break repair nuclease — RefSeq protein ID (P637): XP_006718905. Q20641742. Retrieved 2020-05-30. wikidata.org.
[16] ↑ MRE11 homolog, double strand break repair nuclease — RefSeq protein ID (P637): XP_011541139. Q20641742. Retrieved 2020-05-30. wikidata.org.
[17] ↑ MRE11 homolog, double strand break repair nuclease — RefSeq protein ID (P637): XP_016873261. Q20641742. Retrieved 2020-05-30. wikidata.org.
[18] ↑ MRE11 homolog, double strand break repair nuclease — PDB structure ID (P638): 3T1I. Q905695. Retrieved 2016-08-04. wikidata.org.
[19] ↑ MRE11 homolog, double strand break repair nuclease — molecular function (P680): DNA binding. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ MRE11 homolog, double strand break repair nuclease — molecular function (P680): manganese ion binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ MRE11 homolog, double strand break repair nuclease — molecular function (P680): DNA helicase activity. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ MRE11 homolog, double strand break repair nuclease — molecular function (P680): single-stranded DNA endodeoxyribonuclease activity. Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ MRE11 homolog, double strand break repair nuclease — molecular function (P680): protein C-terminus binding. The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ MRE11 homolog, double strand break repair nuclease — molecular function (P680): protein binding. MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ MRE11 homolog, double strand break repair nuclease — molecular function (P680): 3'-5' exonuclease activity. The 3′ to 5′ Exonuclease Activity of Mre11 Facilitates Repair of DNA Double-Strand Breaks. Retrieved 2017-10-17. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ MRE11 homolog, double strand break repair nuclease — molecular function (P680): nuclease activity. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ MRE11 homolog, double strand break repair nuclease is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). MRE11 homolog, double strand break repair nuclease. Retrieved May 3, 2026, from https://4ort.xyz/entity/mre11-homolog-double-strand-break-repair-nuclease-q2073928

MLA

“MRE11 homolog, double strand break repair nuclease.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/mre11-homolog-double-strand-break-repair-nuclease-q2073928.

BibTeX

@misc{4ortxyz_mre11-homolog-double-strand-break-repair-nuclease-q2073928_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{MRE11 homolog, double strand break repair nuclease}}, year = {2026}, url = {https://4ort.xyz/entity/mre11-homolog-double-strand-break-repair-nuclease-q2073928}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): MRE11 homolog, double strand break repair nuclease — https://4ort.xyz/entity/mre11-homolog-double-strand-break-repair-nuclease-q2073928 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/mre11-homolog-double-strand-break-repair-nuclease-q2073928 · Last refreshed: May 3, 2026