MER proto-oncogene, tyrosine kinase

mammalian protein found in Homo sapiens

Protein protein Q21120828

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MER proto-oncogene, tyrosine kinase

Summary

MER proto-oncogene, tyrosine kinase is a protein^[1].

Key Facts

MER proto-oncogene, tyrosine kinase's instance of is recorded as protein^[2].
MER proto-oncogene, tyrosine kinase is part of Fibronectin type III superfamily^[3].
MER proto-oncogene, tyrosine kinase is part of Immunoglobulin-like fold^[4].
MER proto-oncogene, tyrosine kinase is part of Protein kinase-like domain superfamily^[5].
MER proto-oncogene, tyrosine kinase is part of Immunoglobulin-like domain superfamily^[6].
MER proto-oncogene, tyrosine kinase is part of Fibronectin type III, protein family^[7].
MER proto-oncogene, tyrosine kinase is part of Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family^[8].
MER proto-oncogene, tyrosine kinase is part of immunoglobulin subtype, protein family^[9].
MER proto-oncogene, tyrosine kinase is part of Protein kinase domain, protein family^[10].
MER proto-oncogene, tyrosine kinase is part of immunoglobulin-like domain, protein family^[11].
MER proto-oncogene, tyrosine kinase is part of Protein kinase, ATP binding site, protein family^[12].
MER proto-oncogene, tyrosine kinase is part of Tyrosine-protein kinase, catalytic domain, protein family^[13].
MER proto-oncogene, tyrosine kinase is part of Tyrosine-protein kinase, active site, protein family^[14].
MER proto-oncogene, tyrosine kinase is part of Immunoglobulin domain, protein family^[15].
MER proto-oncogene, tyrosine kinase comprises immunoglobulin domain^[16].
MER proto-oncogene, tyrosine kinase comprises tyrosine-protein kinase, active site^[17].
MER proto-oncogene, tyrosine kinase comprises fibronectin type III^[18].
MER proto-oncogene, tyrosine kinase comprises protein kinase, ATP binding site^[19].
MER proto-oncogene, tyrosine kinase comprises protein kinase domain^[20].
MER proto-oncogene, tyrosine kinase comprises immunoglobulin-like domain^[21].
MER proto-oncogene, tyrosine kinase comprises tyrosine-protein kinase, catalytic domain^[22].
MER proto-oncogene, tyrosine kinase comprises serine-threonine/tyrosine-protein kinase, catalytic domain^[23].
MER proto-oncogene, tyrosine kinase comprises immunoglobulin subtype^[24].
MER proto-oncogene, tyrosine kinase's molecular function is recorded as ATP binding^[25].
MER proto-oncogene, tyrosine kinase's molecular function is recorded as protein tyrosine kinase activity^[26].

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Quick Facts

Instance of protein

Part of Fibronectin type III superfamily, Immunoglobulin-like fold, Protein kinase-like domain superfamily, Immunoglobulin-like domain superfamily, Fibronectin type III, protein family, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, immunoglobulin subtype, protein family, Protein kinase domain, protein family, immunoglobulin-like domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, active site, protein family, Immunoglobulin domain, protein family

Properties

Biological process spermatogenesis, vagina development, protein kinase B signaling, natural killer cell differentiation, cell surface receptor signaling pathway, protein phosphorylation, platelet activation, cell-cell signaling, positive regulation of phagocytosis, apoptotic cell clearance, substrate adhesion-dependent cell spreading, leukocyte migration, negative regulation of lymphocyte activation, phosphorylation, retina development in camera-type eye, negative regulation of leukocyte apoptotic process, phagocytosis, secretion by cell, peptidyl-tyrosine phosphorylation, negative regulation of cytokine production, neutrophil clearance, phagocytosis, negative regulation of signal transduction, Wnt signaling pathway, cell differentiation, negative regulation of apoptotic process, positive regulation of ERK1 and ERK2 cascade, transmembrane receptor protein tyrosine kinase signaling pathway, nervous system development, cell migration

Cell component integral component of membrane, photoreceptor outer segment, rhabdomere, membrane, integral component of plasma membrane, plasma membrane, cytoplasm, extracellular space, cytoplasm, integral component of plasma membrane, receptor complex

Ec enzyme number 2.7.10.1

Encoded by MERTK

Found in taxon Homo sapiens

Has part(s) immunoglobulin domain, tyrosine-protein kinase, active site, fibronectin type III, protein kinase, ATP binding site, protein kinase domain, immunoglobulin-like domain, tyrosine-protein kinase, catalytic domain, serine-threonine/tyrosine-protein kinase, catalytic domain, immunoglobulin subtype

Molecular function ATP binding, protein tyrosine kinase activity, protein kinase activity, protein binding, transmembrane receptor protein tyrosine kinase activity, kinase activity, nucleotide binding, transferase activity, receptor tyrosine kinase, transmembrane signaling receptor activity, Wnt-protein binding, transmembrane receptor protein tyrosine kinase activity

External References (7)

Ensembl protein id ENSP00000295408, ENSP00000389152, ENSP00000387277, ENSP00000402129, ENSP00000412660, ENSP00000482824

Mesh descriptor id D000076202

Mesh tree code D08.811.913.696.620.682.725.400.003, D12.776.476.568.400.003, D12.776.543.750.630.003, D12.776.624.664.700.037

Pdb structure id 2DBJ, 2P0C, 3BPR, 3BRB, 3TCP, 4M3Q, 4MH7, 4MHA

Refseq protein id NP_006334

Umls cui C4318438

Uniprot protein id Sabre St. Simon

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ MER proto-oncogene, tyrosine kinase — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ MER proto-oncogene, tyrosine kinase — part of (P361): Fibronectin type III superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[4] ↑ MER proto-oncogene, tyrosine kinase — part of (P361): Immunoglobulin-like fold. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ MER proto-oncogene, tyrosine kinase — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ MER proto-oncogene, tyrosine kinase — part of (P361): Immunoglobulin-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ MER proto-oncogene, tyrosine kinase — part of (P361): Fibronectin type III, protein family. wikidata.org.
[8] ↑ MER proto-oncogene, tyrosine kinase — part of (P361): Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[9] ↑ MER proto-oncogene, tyrosine kinase — part of (P361): immunoglobulin subtype, protein family. wikidata.org.
[10] ↑ MER proto-oncogene, tyrosine kinase — part of (P361): Protein kinase domain, protein family. wikidata.org.
[11] ↑ MER proto-oncogene, tyrosine kinase — part of (P361): immunoglobulin-like domain, protein family. wikidata.org.
[12] ↑ MER proto-oncogene, tyrosine kinase — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[13] ↑ MER proto-oncogene, tyrosine kinase — part of (P361): Tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[14] ↑ MER proto-oncogene, tyrosine kinase — part of (P361): Tyrosine-protein kinase, active site, protein family. wikidata.org.
[15] ↑ MER proto-oncogene, tyrosine kinase — part of (P361): Immunoglobulin domain, protein family. wikidata.org.
[16] ↑ MER proto-oncogene, tyrosine kinase — has part(s) (P527): immunoglobulin domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ MER proto-oncogene, tyrosine kinase — has part(s) (P527): tyrosine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ MER proto-oncogene, tyrosine kinase — has part(s) (P527): fibronectin type III. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ MER proto-oncogene, tyrosine kinase — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ MER proto-oncogene, tyrosine kinase — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ MER proto-oncogene, tyrosine kinase — has part(s) (P527): immunoglobulin-like domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ MER proto-oncogene, tyrosine kinase — has part(s) (P527): tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ MER proto-oncogene, tyrosine kinase — has part(s) (P527): serine-threonine/tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ MER proto-oncogene, tyrosine kinase — has part(s) (P527): immunoglobulin subtype. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ MER proto-oncogene, tyrosine kinase — molecular function (P680): ATP binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ MER proto-oncogene, tyrosine kinase — molecular function (P680): protein tyrosine kinase activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ MER proto-oncogene, tyrosine kinase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). MER proto-oncogene, tyrosine kinase. Retrieved May 3, 2026, from https://4ort.xyz/entity/mer-proto-oncogene-tyrosine-kinase-q21120828

MLA

“MER proto-oncogene, tyrosine kinase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/mer-proto-oncogene-tyrosine-kinase-q21120828.

BibTeX

@misc{4ortxyz_mer-proto-oncogene-tyrosine-kinase-q21120828_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{MER proto-oncogene, tyrosine kinase}}, year = {2026}, url = {https://4ort.xyz/entity/mer-proto-oncogene-tyrosine-kinase-q21120828}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): MER proto-oncogene, tyrosine kinase — https://4ort.xyz/entity/mer-proto-oncogene-tyrosine-kinase-q21120828 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/mer-proto-oncogene-tyrosine-kinase-q21120828 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

7d ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Found in taxon → Homo sapiens

Mesh tree code → D08.811.913.696.620.682.725.400.003, D12.776.476.568.400.003, D12.776.543.750.630.003 +1

Wikidata description → mammalian protein found in Homo sapiens

Pdb structure id → 2DBJ, 2P0C, 3BPR +5

+ 14 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.7.10.1, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"

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