Macrophage migration inhibitory factor

mammalian protein found in Homo sapiens

Protein protein Q133582

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Macrophage migration inhibitory factor

Summary

Macrophage migration inhibitory factor is a protein^[1].

Key Facts

Macrophage migration inhibitory factor's instance of is recorded as protein^[2].
Macrophage migration inhibitory factor is part of Tautomerase/MIF superfamily^[3].
Macrophage migration inhibitory factor is part of macrophage migration inhibitory factor^[4].
Macrophage migration inhibitory factor is part of Macrophage migration inhibitory factor, conserved site, protein family^[5].
Macrophage migration inhibitory factor comprises Macrophage migration inhibitory factor, conserved site^[6].
Macrophage migration inhibitory factor's EC enzyme number is recorded as 5.3.3.12^[7].
Macrophage migration inhibitory factor's molecular function is recorded as cytokine activity^[8].
Macrophage migration inhibitory factor's molecular function is recorded as isomerase activity^[9].
Macrophage migration inhibitory factor's molecular function is recorded as protein binding^[10].

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Quick Facts

Instance of protein

Part of Tautomerase/MIF superfamily, macrophage migration inhibitory factor, Macrophage migration inhibitory factor, conserved site, protein family

Properties

Biological process positive regulation of protein phosphorylation, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, positive regulation of MAP kinase activity, carboxylic acid metabolic process, positive regulation of chemokine (C-X-C motif) ligand 2 production, immune system process, positive regulation of fibroblast proliferation, DNA damage response, signal transduction by p53 class mediator, negative regulation of apoptotic process, negative regulation of mature B cell apoptotic process, negative regulation of gene expression, positive regulation of peptidyl-serine phosphorylation, protein homotrimerization, positive regulation of lipopolysaccharide-mediated signaling pathway, cell surface receptor signaling pathway, negative regulation of DNA damage response, signal transduction by p53 class mediator, regulation of cell population proliferation, positive regulation of arachidonic acid secretion, positive regulation of B cell proliferation, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of prostaglandin secretion involved in immune response, prostaglandin biosynthetic process, innate immune response, negative regulation of myeloid cell apoptotic process, inflammatory response, cell population proliferation, positive regulation of phosphorylation, positive regulation of myeloid leukocyte cytokine production involved in immune response, leukocyte migration, regulation of macrophage activation, positive regulation of protein kinase A signaling, positive chemotaxis, neutrophil degranulation, interleukin-12-mediated signaling pathway, negative regulation of macrophage chemotaxis, positive regulation of tumor necrosis factor production, positive regulation of ERK1 and ERK2 cascade, regulation of signaling receptor activity

Cell component vesicle, myelin sheath, nucleoplasm, extracellular region, cell surface, extracellular exosome, cytoplasm, cytosol, secretory granule lumen, ficolin-1-rich granule lumen, extracellular space, extracellular region, vesicle, extracellular exosome

Ec enzyme number 5.3.3.12, 5.3.2.1

Encoded by MIF

Exact match purl.uniprot.org

Found in taxon Homo sapiens

Has part(s) Macrophage migration inhibitory factor, conserved site

Molecular function cytokine activity, isomerase activity, protein binding, chemoattractant activity, phenylpyruvate tautomerase activity, signaling receptor binding, dopachrome isomerase activity, protease binding, cytokine receptor binding, identical protein binding

External References (4)

Ensembl protein id ENSP00000215754, ENSP00000482779

Pdb structure id 1CA7, 1CGQ, 1GCZ, 1GD0, 1GIF, 1LJT, 1MIF, 1P1G, 2OOH, 2OOW, 2OOZ, 3B9S, 3CE4, 3DJH, 3DJI, 3HOF, 3IJG, 3IJJ, 3JSF, 3JSG, 3JTU, 3L5P, 3L5R, 3L5S, 3L5T, 3L5U, 3L5V, 3SMB, 3SMC, 3U18, 4ETG, 4EUI, 4EVG, 4F2K, 4GRN, 4GRO, 4GRP, 4GRQ, 4GRR, 4GRU, 3WNR, 3WNS, 3WNT, 4K9G, 4OSF, 4OYQ, 4P01, 4P0H, 4WR8, 4WRB, 4PKZ, 4PLU, 4TRF, 4TRU, 4XX7, 4XX8, 5BS9, 5BSC, 5BSI, 5EIZ, 5HVV, 5CG4, 5J7Q, 5BSJ, 5HVT, 4PKK, 5B4O, 5HVS, 5J7P

Refseq protein id NP_002406

Uniprot protein id P14174

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Macrophage migration inhibitory factor — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Macrophage migration inhibitory factor — part of (P361): Tautomerase/MIF superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[4] ↑ Macrophage migration inhibitory factor — part of (P361): macrophage migration inhibitory factor. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Macrophage migration inhibitory factor — part of (P361): Macrophage migration inhibitory factor, conserved site, protein family. wikidata.org.
[6] ↑ Macrophage migration inhibitory factor — has part(s) (P527): Macrophage migration inhibitory factor, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Macrophage migration inhibitory factor — EC enzyme number (P591): 5.3.3.12. Swiss-Prot. Retrieved 2016-01-12. uniprot.org. Provenance: wikidata.org.
[8] ↑ Macrophage migration inhibitory factor — molecular function (P680): cytokine activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Macrophage migration inhibitory factor — molecular function (P680): isomerase activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Macrophage migration inhibitory factor — molecular function (P680): protein binding. The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Macrophage migration inhibitory factor is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Macrophage migration inhibitory factor. Retrieved May 3, 2026, from https://4ort.xyz/entity/macrophage-migration-inhibitory-factor-q133582

MLA

“Macrophage migration inhibitory factor.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/macrophage-migration-inhibitory-factor-q133582.

BibTeX

@misc{4ortxyz_macrophage-migration-inhibitory-factor-q133582_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Macrophage migration inhibitory factor}}, year = {2026}, url = {https://4ort.xyz/entity/macrophage-migration-inhibitory-factor-q133582}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Macrophage migration inhibitory factor — https://4ort.xyz/entity/macrophage-migration-inhibitory-factor-q133582 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/macrophage-migration-inhibitory-factor-q133582 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

27d ago · Boghog · 2026-07-22 view diff on Wikidata ↗

Uniprot protein id → P14174

Ec enzyme number → 5.3.3.12

Refseq protein id → NP_002406

Exact match → http://purl.uniprot.org/uniprot/P14174

+ 12 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 5.3.2.1, #quickstatements; #temporary_batch_1784744182951"

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