Lysine methyltransferase 2D

mammalian protein found in Homo sapiens

Protein protein Q21107293

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Lysine methyltransferase 2D

Summary

Lysine methyltransferase 2D is a protein^[1].

Key Facts

Lysine methyltransferase 2D's instance of is recorded as protein^[2].
Lysine methyltransferase 2D is part of Zinc finger, FYVE/PHD-type^[3].
Lysine methyltransferase 2D is part of Zinc finger, RING/FYVE/PHD-type^[4].
Lysine methyltransferase 2D is part of High mobility group box domain superfamily^[5].
Lysine methyltransferase 2D is part of Histone-lysine N-methyltransferase 2D^[6].
Lysine methyltransferase 2D is part of FY-rich, C-terminal domain, protein family^[7].
Lysine methyltransferase 2D is part of Zinc finger, PHD-finger, protein family^[8].
Lysine methyltransferase 2D is part of High mobility group box domain, protein family^[9].
Lysine methyltransferase 2D is part of FY-rich, N-terminal domain, protein family^[10].
Lysine methyltransferase 2D is part of Zinc finger, PHD-type, protein family^[11].
Lysine methyltransferase 2D is part of Post-SET domain, protein family^[12].
Lysine methyltransferase 2D is part of Zinc finger, RING-type, protein family^[13].
Lysine methyltransferase 2D is part of Extended PHD (ePHD) domain, protein family^[14].
Lysine methyltransferase 2D is part of SET domain, protein family^[15].
Lysine methyltransferase 2D comprises High mobility group box domain^[16].
Lysine methyltransferase 2D comprises Zinc finger, PHD-type^[17].
Lysine methyltransferase 2D comprises SET domain^[18].
Lysine methyltransferase 2D comprises Post-SET domain^[19].
Lysine methyltransferase 2D comprises FY-rich, C-terminal^[20].
Lysine methyltransferase 2D comprises Zinc finger, RING-type^[21].
Lysine methyltransferase 2D comprises Zinc finger, PHD-finger^[22].
Lysine methyltransferase 2D comprises FY-rich, N-terminal^[23].
Lysine methyltransferase 2D comprises Extended PHD (ePHD) domain^[24].
Lysine methyltransferase 2D's molecular function is recorded as metal ion binding^[25].
Lysine methyltransferase 2D's molecular function is recorded as transferase activity^[26].

⭐ Popularity Graph

0/100 established

Quick Facts

Instance of protein

Part of Zinc finger, FYVE/PHD-type, Zinc finger, RING/FYVE/PHD-type, High mobility group box domain superfamily, Histone-lysine N-methyltransferase 2D, FY-rich, C-terminal domain, protein family, Zinc finger, PHD-finger, protein family, High mobility group box domain, protein family, FY-rich, N-terminal domain, protein family, Zinc finger, PHD-type, protein family, Post-SET domain, protein family, Zinc finger, RING-type, protein family, Extended PHD (ePHD) domain, protein family, SET domain, protein family

Properties

Biological process positive regulation of intracellular estrogen receptor signaling pathway, transcription, DNA-templated, methylation, positive regulation of cell population proliferation, oogenesis, oocyte growth, response to estrogen, positive regulation of transcription by RNA polymerase II, histone H3-K4 methylation, regulation of transcription, DNA-templated, beta-catenin-TCF complex assembly, regulation of megakaryocyte differentiation, chromatin organization, regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II

Cell component nucleoplasm, MLL3/4 complex, nucleus, histone methyltransferase complex, MLL3/4 complex

Ec enzyme number 2.1.1.364

Encoded by KMT2D

Found in taxon Homo sapiens

Has part(s) High mobility group box domain, Zinc finger, PHD-type, SET domain, Post-SET domain, FY-rich, C-terminal, Zinc finger, RING-type, Zinc finger, PHD-finger, FY-rich, N-terminal, Extended PHD (ePHD) domain

Molecular function metal ion binding, transferase activity, DNA binding, methyltransferase activity, protein binding, histone-lysine N-methyltransferase activity, histone methyltransferase activity (H3-K4 specific), DNA-binding transcription factor activity, RNA polymerase II-specific, transcription coactivator activity, histone binding, histone methyltransferase activity (H3-K4 specific), histone-lysine N-methyltransferase activity

External References (4)

Ensembl protein id ENSP00000301067, ENSP00000435714, ENSP00000449455, ENSP00000497218

Pdb structure id 3UVK, 4ERQ, 4Z4P

Refseq protein id NP_003473, XP_006719677, XP_006719679, XP_011537072, XP_011537073, XP_011537074, XP_011537075, XP_011537076, XP_011537078

Uniprot protein id O14686

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Lysine methyltransferase 2D — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Lysine methyltransferase 2D — part of (P361): Zinc finger, FYVE/PHD-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[4] ↑ Lysine methyltransferase 2D — part of (P361): Zinc finger, RING/FYVE/PHD-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Lysine methyltransferase 2D — part of (P361): High mobility group box domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Lysine methyltransferase 2D — part of (P361): Histone-lysine N-methyltransferase 2D. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Lysine methyltransferase 2D — part of (P361): FY-rich, C-terminal domain, protein family. wikidata.org.
[8] ↑ Lysine methyltransferase 2D — part of (P361): Zinc finger, PHD-finger, protein family. wikidata.org.
[9] ↑ Lysine methyltransferase 2D — part of (P361): High mobility group box domain, protein family. wikidata.org.
[10] ↑ Lysine methyltransferase 2D — part of (P361): FY-rich, N-terminal domain, protein family. wikidata.org.
[11] ↑ Lysine methyltransferase 2D — part of (P361): Zinc finger, PHD-type, protein family. wikidata.org.
[12] ↑ Lysine methyltransferase 2D — part of (P361): Post-SET domain, protein family. wikidata.org.
[13] ↑ Lysine methyltransferase 2D — part of (P361): Zinc finger, RING-type, protein family. wikidata.org.
[14] ↑ Lysine methyltransferase 2D — part of (P361): Extended PHD (ePHD) domain, protein family. wikidata.org.
[15] ↑ Lysine methyltransferase 2D — part of (P361): SET domain, protein family. wikidata.org.
[16] ↑ Lysine methyltransferase 2D — has part(s) (P527): High mobility group box domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Lysine methyltransferase 2D — has part(s) (P527): Zinc finger, PHD-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Lysine methyltransferase 2D — has part(s) (P527): SET domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Lysine methyltransferase 2D — has part(s) (P527): Post-SET domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Lysine methyltransferase 2D — has part(s) (P527): FY-rich, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Lysine methyltransferase 2D — has part(s) (P527): Zinc finger, RING-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Lysine methyltransferase 2D — has part(s) (P527): Zinc finger, PHD-finger. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Lysine methyltransferase 2D — has part(s) (P527): FY-rich, N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Lysine methyltransferase 2D — has part(s) (P527): Extended PHD (ePHD) domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Lysine methyltransferase 2D — molecular function (P680): metal ion binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Lysine methyltransferase 2D — molecular function (P680): transferase activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Lysine methyltransferase 2D is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Lysine methyltransferase 2D. Retrieved May 3, 2026, from https://4ort.xyz/entity/lysine-methyltransferase-2d

MLA

“Lysine methyltransferase 2D.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/lysine-methyltransferase-2d.

BibTeX

@misc{4ortxyz_lysine-methyltransferase-2d_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Lysine methyltransferase 2D}}, year = {2026}, url = {https://4ort.xyz/entity/lysine-methyltransferase-2d}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Lysine methyltransferase 2D — https://4ort.xyz/entity/lysine-methyltransferase-2d (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/lysine-methyltransferase-2d · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

6d ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Imported from → —

Encoded by → KMT2D

Wikidata description → mammalian protein found in Homo sapiens

Molecular function → metal ion binding, transferase activity, DNA binding +9

+ 11 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.1.1.364, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"

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