Kalirin RhoGEF kinase

mammalian protein found in Homo sapiens

Protein protein Q4104271

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Kalirin RhoGEF kinase

Summary

Kalirin RhoGEF kinase is a protein^[1].

Key Facts

Kalirin RhoGEF kinase's instance of is recorded as protein^[2].
Kalirin RhoGEF kinase is part of Immunoglobulin-like fold^[3].
Kalirin RhoGEF kinase is part of Protein kinase-like domain superfamily^[4].
Kalirin RhoGEF kinase is part of CRAL-TRIO lipid binding domain superfamily^[5].
Kalirin RhoGEF kinase is part of SH3-like domain superfamily^[6].
Kalirin RhoGEF kinase is part of Fibronectin type III superfamily^[7].
Kalirin RhoGEF kinase is part of Dbl homology (DH) domain superfamily^[8].
Kalirin RhoGEF kinase is part of PH-like domain superfamily^[9].
Kalirin RhoGEF kinase is part of CRAL-TRIO lipid binding domain, protein family^[10].
Kalirin RhoGEF kinase is part of Immunoglobulin I-set, protein family^[11].
Kalirin RhoGEF kinase is part of Fibronectin type III, protein family^[12].
Kalirin RhoGEF kinase is part of pleckstrin homology domain, protein family^[13].
Kalirin RhoGEF kinase is part of immunoglobulin subtype, protein family^[14].
Kalirin RhoGEF kinase is part of Dbl homology (DH) domain, protein family^[15].
Kalirin RhoGEF kinase is part of SH3 domain, protein family^[16].
Kalirin RhoGEF kinase is part of Immunoglobulin subtype 2, protein family^[17].
Kalirin RhoGEF kinase is part of Protein kinase domain, protein family^[18].
Kalirin RhoGEF kinase is part of immunoglobulin-like domain, protein family^[19].
Kalirin RhoGEF kinase is part of Protein kinase, ATP binding site, protein family^[20].
Kalirin RhoGEF kinase is part of Spectrin repeat, protein family^[21].
Kalirin RhoGEF kinase is part of Spectrin/alpha-actinin, protein family^[22].
Kalirin RhoGEF kinase is part of Serine/threonine-protein kinase, active site, protein family^[23].
Kalirin RhoGEF kinase comprises Spectrin/alpha-actinin^[24].
Kalirin RhoGEF kinase comprises Dbl homology (DH) domain^[25].
Kalirin RhoGEF kinase comprises immunoglobulin subtype 2^[26].

⭐ Popularity Graph

0/100 established

Quick Facts

Instance of protein

Part of Immunoglobulin-like fold, Protein kinase-like domain superfamily, CRAL-TRIO lipid binding domain superfamily, SH3-like domain superfamily, Fibronectin type III superfamily, Dbl homology (DH) domain superfamily, PH-like domain superfamily, CRAL-TRIO lipid binding domain, protein family, Immunoglobulin I-set, protein family, Fibronectin type III, protein family, pleckstrin homology domain, protein family, immunoglobulin subtype, protein family, Dbl homology (DH) domain, protein family, SH3 domain, protein family, Immunoglobulin subtype 2, protein family, Protein kinase domain, protein family, immunoglobulin-like domain, protein family, Protein kinase, ATP binding site, protein family, Spectrin repeat, protein family, Spectrin/alpha-actinin, protein family, Serine/threonine-protein kinase, active site, protein family

Properties

Biological process intracellular signal transduction, phosphorylation, ephrin receptor signaling pathway, nervous system development, protein phosphorylation, positive regulation of apoptotic process, regulation of Rho protein signal transduction, regulation of small GTPase mediated signal transduction, vesicle-mediated transport, signal transduction, positive regulation of dendritic spine morphogenesis, behavioral response to cocaine, behavioral fear response, social behavior, regulation of protein localization to plasma membrane, positive regulation of GTPase activity, regulation of synaptic transmission, glutamatergic, memory, positive regulation of dendritic spine development, Rho protein signal transduction, neuromuscular junction development, lactation, adult locomotory behavior, response to mechanical stimulus, smooth muscle cell migration, Maternal behavior, habituation, regulation of neuronal synaptic plasticity, smooth muscle cell proliferation, negative regulation of growth hormone secretion, maternal process involved in parturition, behavioral response to formalin induced pain, positive regulation of long-term synaptic potentiation, G protein-coupled receptor signaling pathway

Cell component cytoplasm, actin cytoskeleton, extracellular exosome, cytoskeleton, nucleoplasm, cytosol, postsynaptic density, extracellular exosome

Ec enzyme number 2.7.11.1

Encoded by KALRN

Found in taxon Homo sapiens

Has part(s) Spectrin/alpha-actinin, Dbl homology (DH) domain, immunoglobulin subtype 2, fibronectin type III, Spectrin repeat, SH3 domain, CRAL-TRIO lipid binding domain, pleckstrin homology domain, protein kinase domain, immunoglobulin-like domain, protein kinase, ATP binding site, serine/threonine-protein kinase, active site, immunoglobulin I-set, immunoglobulin subtype

Molecular function transferase activity, nucleotide binding, protein kinase activity, guanyl-nucleotide exchange factor activity, metal ion binding, kinase activity, protein serine/threonine kinase activity, protein binding, ATP binding, GTPase activator activity

External References (5)

Ensembl protein id ENSP00000240874, ENSP00000291478, ENSP00000346122, ENSP00000353109, ENSP00000395236, ENSP00000400064, ENSP00000402950, ENSP00000418611, ENSP00000487487

Freebase id /m/03d6_jz

Pdb structure id 1WFW

Refseq protein id NP_001019831, NP_001309917, NP_001309918, NP_001309919, NP_001309920, NP_001309921, NP_001309922, NP_001309923, NP_001309924, NP_001309925, NP_001309926, NP_001309927, NP_001309928, NP_001309929, NP_001309930, NP_003938, NP_008995, XP_006713873, XP_006713874, XP_006713875, XP_006713876, XP_006713877, XP_006713878, XP_011511581, XP_011511582, XP_011511583, XP_011511585, XP_011511587, XP_016862918, XP_016862919, XP_016862920, XP_016862921, XP_016862922, XP_016862923, XP_016862924, XP_024309579

Uniprot protein id O60229

🏷️ Also known as

en Huntingtin-associated protein-interacting protein en huntingtin-associated protein interacting protein (duo) en kalirin en Kalirin RhoGEF kinase en KALRN en Protein Duo en serine/threonine-protein kinase with Dbl- and pleckstrin homology domain fi Kaliriini ru Калирин

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Kalirin RhoGEF kinase — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Kalirin RhoGEF kinase — part of (P361): Immunoglobulin-like fold. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[4] ↑ Kalirin RhoGEF kinase — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Kalirin RhoGEF kinase — part of (P361): CRAL-TRIO lipid binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Kalirin RhoGEF kinase — part of (P361): SH3-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Kalirin RhoGEF kinase — part of (P361): Fibronectin type III superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Kalirin RhoGEF kinase — part of (P361): Dbl homology (DH) domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Kalirin RhoGEF kinase — part of (P361): PH-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Kalirin RhoGEF kinase — part of (P361): CRAL-TRIO lipid binding domain, protein family. wikidata.org.
[11] ↑ Kalirin RhoGEF kinase — part of (P361): Immunoglobulin I-set, protein family. wikidata.org.
[12] ↑ Kalirin RhoGEF kinase — part of (P361): Fibronectin type III, protein family. wikidata.org.
[13] ↑ Kalirin RhoGEF kinase — part of (P361): pleckstrin homology domain, protein family. wikidata.org.
[14] ↑ Kalirin RhoGEF kinase — part of (P361): immunoglobulin subtype, protein family. wikidata.org.
[15] ↑ Kalirin RhoGEF kinase — part of (P361): Dbl homology (DH) domain, protein family. wikidata.org.
[16] ↑ Kalirin RhoGEF kinase — part of (P361): SH3 domain, protein family. wikidata.org.
[17] ↑ Kalirin RhoGEF kinase — part of (P361): Immunoglobulin subtype 2, protein family. wikidata.org.
[18] ↑ Kalirin RhoGEF kinase — part of (P361): Protein kinase domain, protein family. wikidata.org.
[19] ↑ Kalirin RhoGEF kinase — part of (P361): immunoglobulin-like domain, protein family. wikidata.org.
[20] ↑ Kalirin RhoGEF kinase — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[21] ↑ Kalirin RhoGEF kinase — part of (P361): Spectrin repeat, protein family. wikidata.org.
[22] ↑ Kalirin RhoGEF kinase — part of (P361): Spectrin/alpha-actinin, protein family. wikidata.org.
[23] ↑ Kalirin RhoGEF kinase — part of (P361): Serine/threonine-protein kinase, active site, protein family. wikidata.org.
[24] ↑ Kalirin RhoGEF kinase — has part(s) (P527): Spectrin/alpha-actinin. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Kalirin RhoGEF kinase — has part(s) (P527): Dbl homology (DH) domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Kalirin RhoGEF kinase — has part(s) (P527): immunoglobulin subtype 2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Kalirin RhoGEF kinase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Kalirin RhoGEF kinase. Retrieved May 3, 2026, from https://4ort.xyz/entity/kalirin-rhogef-kinase-q4104271

MLA

“Kalirin RhoGEF kinase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/kalirin-rhogef-kinase-q4104271.

BibTeX

@misc{4ortxyz_kalirin-rhogef-kinase-q4104271_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Kalirin RhoGEF kinase}}, year = {2026}, url = {https://4ort.xyz/entity/kalirin-rhogef-kinase-q4104271}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Kalirin RhoGEF kinase — https://4ort.xyz/entity/kalirin-rhogef-kinase-q4104271 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/kalirin-rhogef-kinase-q4104271 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

5w ago · Boghog · 2026-07-23 view diff on Wikidata ↗

Uniprot protein id → O60229

Ec enzyme number → 2.7.11.1

Refseq protein id → NP_001019831, NP_001309917, NP_001309918 +33

Imported from → —

+ 12 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.7.11.1, [[:toollabs:quickstatements/#/batch/261446|batch #261446]]"

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