Home › Entities › gene › INS

INS

protein-coding gene in Homo sapiens
Gene gene Q21163221
Press Enter · cited answer in seconds

INS

Summary

INS is a gene[1]. INS ranks in the top 2% of gene entities by monthly Wikipedia readership (4 views/month).[2]

Key Facts

  • INS's instance of is recorded as gene[3].
  • INS is a type of protein-coding gene[4].
  • INS's Commons category is recorded as Insulin[5].
  • INS's HomoloGene ID is recorded as 173[6].
  • INS's genomic start is recorded as 2159779[7].
  • INS's genomic start is recorded as 2181009[8].
  • INS's genomic end is recorded as 2182571[9].
  • INS's genomic end is recorded as 2161221[10].
  • INS's biological process is recorded as negative regulation of NAD(P)H oxidase activity[11].
  • INS's biological process is recorded as positive regulation of DNA replication[12].
  • INS's biological process is recorded as positive regulation of MAPK cascade[13].
  • INS's biological process is recorded as positive regulation of brown fat cell differentiation[14].
  • INS's biological process is recorded as positive regulation of cell differentiation[15].
  • INS's biological process is recorded as MAPK cascade[16].
  • INS's biological process is recorded as positive regulation of respiratory burst[17].
  • INS's biological process is recorded as positive regulation of phosphatidylinositol 3-kinase signaling[18].
  • INS's biological process is recorded as negative regulation of protein oligomerization[19].
  • INS's biological process is recorded as positive regulation of NF-kappaB transcription factor activity[20].
  • INS's biological process is recorded as negative regulation of respiratory burst involved in inflammatory response[21].
  • INS's biological process is recorded as cell-cell signaling[22].
  • INS's biological process is recorded as positive regulation of nitric oxide biosynthetic process[23].
  • INS's biological process is recorded as positive regulation of glycolytic process[24].
  • INS's biological process is recorded as positive regulation of nitric-oxide synthase activity[25].
  • INS's biological process is recorded as positive regulation of protein autophosphorylation[26].
  • INS's biological process is recorded as activation of protein kinase B activity[27].

Why It Matters

INS ranks in the top 2% of gene entities by monthly Wikipedia readership (4 views/month).[2]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . ensembl Release 106. wikidata.org.
  2. [4] ↑ . Ensembl Release 87. wikidata.org.
  3. [5] ↑ . wikidata.org.
  4. [6] ↑ . Q20641742. Retrieved . wikidata.org.
  5. [7] ↑ . ensembl Release 106. wikidata.org.
  6. [8] ↑ . ensembl Release 106. wikidata.org.
  7. [9] ↑ . ensembl Release 106. wikidata.org.
  8. [10] ↑ . ensembl Release 106. wikidata.org.
  9. [11] ↑ . Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [12] ↑ . Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [13] ↑ . A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] ↑ . Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . Insulin signalling and the regulation of glucose and lipid metabolism. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . A structurally abnormal insulin causing human diabetes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] ↑ . Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikimedia Foundation. dumps.wikimedia.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). INS. Retrieved May 3, 2026, from https://4ort.xyz/entity/ins-q21163221
MLA “INS.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/ins-q21163221.
BibTeX @misc{4ortxyz_ins-q21163221_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{INS}}, year = {2026}, url = {https://4ort.xyz/entity/ins-q21163221}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): INS — https://4ort.xyz/entity/ins-q21163221 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/ins-q21163221 · Last refreshed:

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 6w ago · Boghog · 2026-07-19 view diff on Wikidata ↗
    Hgnc gene symbol → INS
    Instance of → gene
    Different from → preproinsulin
    Biological process → negative regulation of NAD(P)H oxidase activity, positive regulation of DNA replication, positive regulation of MAPK cascade +66
    + 30 other properties edited (see Wikidata diff for full list)
    "/* wbsetclaim-update:2||1|1 */ [[Property:P18]]: Insulin struct.png"
Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.