Heat shock protein family A (Hsp70) member 8

mammalian protein found in Rattus norvegicus

Protein protein Q28557394

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Heat shock protein family A (Hsp70) member 8

Summary

Heat shock protein family A (Hsp70) member 8 is a protein^[1].

Key Facts

Heat shock protein family A (Hsp70) member 8's instance of is recorded as protein^[2].
Heat shock protein family A (Hsp70) member 8's UniProt protein ID is recorded as P63018^[3].
Heat shock protein family A (Hsp70) member 8's part of is recorded as Heat shock protein 70kD, peptide-binding domain superfamily^[4].
Heat shock protein family A (Hsp70) member 8's part of is recorded as Heat shock protein 70kD, C-terminal domain superfamily^[5].
Heat shock protein family A (Hsp70) member 8's part of is recorded as Heat shock protein 70 family^[6].
Heat shock protein family A (Hsp70) member 8's part of is recorded as membrane protein^[7].
Heat shock protein family A (Hsp70) member 8's part of is recorded as Heat shock protein 70, conserved site, protein family^[8].
Heat shock protein family A (Hsp70) member 8's has part is recorded as Heat shock protein 70, conserved site^[9].
Heat shock protein family A (Hsp70) member 8's RefSeq protein ID is recorded as NP_077327^[10].
Heat shock protein family A (Hsp70) member 8's molecular function is recorded as nucleotide binding^[11].
Heat shock protein family A (Hsp70) member 8's molecular function is recorded as RNA binding^[12].
Heat shock protein family A (Hsp70) member 8's molecular function is recorded as signaling receptor binding^[13].
Heat shock protein family A (Hsp70) member 8's molecular function is recorded as protein binding^[14].
Heat shock protein family A (Hsp70) member 8's molecular function is recorded as ATP binding^[15].
Heat shock protein family A (Hsp70) member 8's molecular function is recorded as transcription factor binding^[16].
Heat shock protein family A (Hsp70) member 8's molecular function is recorded as ATPase activity^[17].
Heat shock protein family A (Hsp70) member 8's molecular function is recorded as enzyme binding^[18].
Heat shock protein family A (Hsp70) member 8's molecular function is recorded as heat shock protein binding^[19].
Heat shock protein family A (Hsp70) member 8's molecular function is recorded as A1 adenosine receptor binding^[20].
Heat shock protein family A (Hsp70) member 8's molecular function is recorded as peptide binding^[21].
Heat shock protein family A (Hsp70) member 8's molecular function is recorded as ADP binding^[22].
Heat shock protein family A (Hsp70) member 8's molecular function is recorded as protein folding chaperone activity^[23].
Heat shock protein family A (Hsp70) member 8's molecular function is recorded as unfolded protein binding^[24].
Heat shock protein family A (Hsp70) member 8's molecular function is recorded as misfolded protein binding^[25].
Heat shock protein family A (Hsp70) member 8's molecular function is recorded as prostaglandin binding^[26].

⭐ Popularity Graph

1/100 established

Quick Facts

Instance of protein

Part of Heat shock protein 70kD, peptide-binding domain superfamily, Heat shock protein 70kD, C-terminal domain superfamily, Heat shock protein 70 family, membrane protein, Heat shock protein 70, conserved site, protein family

Properties

Biological process G1/S transition of mitotic cell cycle, kidney development, positive regulation of T cell mediated cytotoxicity, mRNA processing, protein import into nucleus, response to unfolded protein, skeletal muscle tissue development, ageing, sensory perception of smell, axo-dendritic transport, RNA splicing, response to heat, response to nickel cation, positive regulation of gene expression, negative regulation of cardiac muscle cell apoptotic process, response to activity, synaptic vesicle uncoating, vesicle-mediated transport, cerebellum development, forebrain development, response to estradiol, response to progesterone, cellular response to heat, Unfolded Protein Response, protein refolding, response to starvation, positive regulation of catalytic activity, protein transmembrane import into intracellular organelle, estrous cycle, response to ethanol, positive regulation of proteolysis, negative regulation of transcription, DNA-templated, protein autophosphorylation, positive regulation of phagocytosis, chaperone cofactor-dependent protein refolding, chaperone-mediated protein folding, regulation of protein complex stability, chaperone-mediated autophagy, late endosomal microautophagy, protein targeting to lysosome involved in chaperone-mediated autophagy, cellular response to cadmium ion, clathrin coat disassembly, positive regulation of lysosomal membrane permeability, maintenance of postsynaptic specialization structure, negative regulation of hydrogen peroxide-induced cell death, positive regulation of protein refolding, chaperone-mediated autophagy translocation complex disassembly, slow axonal transport, response to odorant

Cell component Prp19 complex, photoreceptor inner segment, nucleus, spliceosomal complex, nucleolus, cytoplasm, lysosome, lysosomal membrane, autophagosome, cytosol, microtubule, intermediate filament, plasma membrane, synaptic vesicle, cell surface, postsynaptic density, membrane, axon, dendrite, asymmetric synapse, protein-containing complex, melanosome, neuron projection, soma, terminal bouton, dendritic spine, dendritic shaft, perikaryon, neuron spine, membrane raft, perinuclear region of cytoplasm, extracellular exosome, glycinergic synapse, presynapse, postsynapse, glutamatergic synapse, presynaptic cytosol, postsynaptic cytosol, messenger ribonucleoprotein complex, lysosomal matrix, ribonucleoprotein complex

Encoded by Hspa8

Found in taxon brown rat

Has part(s) Heat shock protein 70, conserved site

Imported from wholeness_audit_2026-05-02

Molecular function nucleotide binding, RNA binding, signaling receptor binding, protein binding, ATP binding, transcription factor binding, ATPase activity, enzyme binding, heat shock protein binding, A1 adenosine receptor binding, peptide binding, ADP binding, protein folding chaperone activity, unfolded protein binding, misfolded protein binding, prostaglandin binding, clathrin-uncoating ATPase activity

External References (3)

Ensembl protein id ENSRNOP00000042159

Refseq protein id NP_077327

Uniprot protein id P63018

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Heat shock protein family A (Hsp70) member 8 — instance of (P31): protein. Q905695. Retrieved 2021-11-17. wikidata.org.
[3] ↑ Heat shock protein family A (Hsp70) member 8 — UniProt protein ID (P352): P63018. Q905695. Retrieved 2021-11-17. wikidata.org.
[4] ↑ Heat shock protein family A (Hsp70) member 8 — part of (P361): Heat shock protein 70kD, peptide-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Heat shock protein family A (Hsp70) member 8 — part of (P361): Heat shock protein 70kD, C-terminal domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Heat shock protein family A (Hsp70) member 8 — part of (P361): Heat shock protein 70 family. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Heat shock protein family A (Hsp70) member 8 — part of (P361): membrane protein. wikidata.org.
[8] ↑ Heat shock protein family A (Hsp70) member 8 — part of (P361): Heat shock protein 70, conserved site, protein family. wikidata.org.
[9] ↑ Heat shock protein family A (Hsp70) member 8 — has part(s) (P527): Heat shock protein 70, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Heat shock protein family A (Hsp70) member 8 — RefSeq protein ID (P637): NP_077327. Q20641742. Retrieved 2021-09-07. wikidata.org.
[11] ↑ Heat shock protein family A (Hsp70) member 8 — molecular function (P680): nucleotide binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Heat shock protein family A (Hsp70) member 8 — molecular function (P680): RNA binding. Identification in the rat brain of a set of nuclear proteins interacting with H1° mRNA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Heat shock protein family A (Hsp70) member 8 — molecular function (P680): signaling receptor binding. Characteristics of the interaction between Hsc70 and the transferrin receptor in exosomes released during reticulocyte maturation. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Heat shock protein family A (Hsp70) member 8 — molecular function (P680): protein binding. Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Heat shock protein family A (Hsp70) member 8 — molecular function (P680): ATP binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Heat shock protein family A (Hsp70) member 8 — molecular function (P680): transcription factor binding. Identification in the rat brain of a set of nuclear proteins interacting with H1° mRNA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Heat shock protein family A (Hsp70) member 8 — molecular function (P680): ATPase activity. The carboxy-terminal domain of Hsc70 provides binding sites for a distinct set of chaperone cofactors. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Heat shock protein family A (Hsp70) member 8 — molecular function (P680): enzyme binding. Constitutive heat shock protein 70 interacts with α-enolase and protects cardiomyocytes against oxidative stress. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Heat shock protein family A (Hsp70) member 8 — molecular function (P680): heat shock protein binding. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Heat shock protein family A (Hsp70) member 8 — molecular function (P680): A1 adenosine receptor binding. The heat shock cognate protein hsc73 assembles with A(1) adenosine receptors to form functional modules in the cell membrane. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Heat shock protein family A (Hsp70) member 8 — molecular function (P680): peptide binding. High-level expression of soluble rat hsc70 in Escherichia coli: purification and characterization of the cloned enzyme. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Heat shock protein family A (Hsp70) member 8 — molecular function (P680): ADP binding. Characteristics of the interaction between Hsc70 and the transferrin receptor in exosomes released during reticulocyte maturation. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Heat shock protein family A (Hsp70) member 8 — molecular function (P680): protein folding chaperone activity. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Heat shock protein family A (Hsp70) member 8 — molecular function (P680): unfolded protein binding. Characteristics of the interaction between Hsc70 and the transferrin receptor in exosomes released during reticulocyte maturation. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Heat shock protein family A (Hsp70) member 8 — molecular function (P680): misfolded protein binding. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Heat shock protein family A (Hsp70) member 8 — molecular function (P680): prostaglandin binding. Proteomic identification of protein targets for 15-deoxy-Δ(12,14)-prostaglandin J2 in neuronal plasma membrane. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Heat shock protein family A (Hsp70) member 8 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

“Heat shock protein family A (Hsp70) member 8.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/heat-shock-protein-family-a-hsp70-member-8-q28557394.

BibTeX

@misc{4ortxyz_heat-shock-protein-family-a-hsp70-member-8-q28557394_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Heat shock protein family A (Hsp70) member 8}}, year = {2026}, url = {https://4ort.xyz/entity/heat-shock-protein-family-a-hsp70-member-8-q28557394}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Heat shock protein family A (Hsp70) member 8 — https://4ort.xyz/entity/heat-shock-protein-family-a-hsp70-member-8-q28557394 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/heat-shock-protein-family-a-hsp70-member-8-q28557394 · Last refreshed: May 3, 2026