Caspase 8

mammalian protein found in Homo sapiens
Protein protein Q5049059
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Caspase 8

Summary

Caspase 8 is a protein[1].

Key Facts

  • Caspase 8's instance of is recorded as protein[2].
  • Caspase 8's physically interacts with is recorded as emricasan[3].
  • Caspase 8 is part of caspase-like domain superfamily[4].
  • Caspase 8 is part of Death-like domain superfamily[5].
  • Caspase 8 is part of Peptidase C14, caspase non-catalytic subunit p10, protein family[6].
  • Caspase 8 is part of Death effector domain, protein family[7].
  • Caspase 8 is part of Peptidase family C14A, cysteine active site, protein family[8].
  • Caspase 8 is part of Peptidase C14, p20 domain, protein family[9].
  • Caspase 8 is part of Peptidase C14A, caspase catalytic domain, protein family[10].
  • Caspase 8 is part of Peptidase family C14A, His active site, protein family[11].
  • Caspase 8 comprises Peptidase family C14A, His active site[12].
  • Caspase 8 comprises Peptidase C14, p20 domain[13].
  • Caspase 8 comprises Peptidase C14A, caspase catalytic domain[14].
  • Caspase 8 comprises Peptidase C14, caspase non-catalytic subunit p10[15].
  • Caspase 8 comprises death effector domain[16].
  • Caspase 8 comprises Peptidase family C14A, cysteine active site[17].
  • Caspase 8's molecular function is recorded as death effector domain binding[18].
  • Caspase 8's molecular function is recorded as cysteine-type peptidase activity[19].
  • Caspase 8's molecular function is recorded as cysteine-type endopeptidase activity involved in apoptotic signaling pathway[20].
  • Caspase 8's molecular function is recorded as scaffold protein binding[21].
  • Caspase 8's molecular function is recorded as protein binding[22].
  • Caspase 8's molecular function is recorded as identical protein binding[23].
  • Caspase 8's molecular function is recorded as cysteine-type endopeptidase activity involved in apoptotic process[24].
  • Caspase 8's molecular function is recorded as cysteine-type endopeptidase activity[25].
  • Caspase 8's molecular function is recorded as hydrolase activity[26].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] . Q905695. Retrieved . wikidata.org.
  2. [3] . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  3. [4] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [5] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [6] . wikidata.org.
  6. [7] . wikidata.org.
  7. [8] . wikidata.org.
  8. [9] . wikidata.org.
  9. [10] . wikidata.org.
  10. [11] . wikidata.org.
  11. [12] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  12. [13] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  13. [14] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  14. [15] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  15. [16] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  16. [17] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  17. [18] . Caspase-10 is an initiator caspase in death receptor signaling. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] . Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [20] . Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [21] . DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [22] . Calcium binding of ARC mediates regulation of caspase 8 and cell death. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [23] . A human protein-protein interaction network: a resource for annotating the proteome. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [24] . cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [25] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [26] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Caspase 8. Retrieved May 3, 2026, from https://4ort.xyz/entity/caspase-8-q5049059
MLA “Caspase 8.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/caspase-8-q5049059.
BibTeX @misc{4ortxyz_caspase-8-q5049059_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Caspase 8}}, year = {2026}, url = {https://4ort.xyz/entity/caspase-8-q5049059}, note = {Accessed: 2026-05-03}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 26d ago · Boghog · 2026-07-23 view diff on Wikidata ↗
    Uniprot protein id Ethnologue
    Exact match http://purl.uniprot.org/uniprot/Q14790
    Imported from
    Mesh descriptor id D053181
    + 16 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ [[Property:P591]]: 3.4.22.61, [[:toollabs:quickstatements/#/batch/261457|batch #261457]]"
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